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Product | Description | |
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Beclabuvir Quick inquiry Where to buy Suppliers range | Beclabuvir is a potent, non-nucleotide inhibitor of HCV NS5B which is currently in Phase III clinical trials for the treatment of chronic HCV infection. Beclabuvir is a thumb site 1-NS5B polymerase ligand. Beclabuvir has been shown to equally inhibit de novo and primer dependent synthesis, 5-75 fold more potently than previously studied compounds, thus resulting the most effective thumb site 1 inhibitor of genotype 1 (GT-1) NS5B polymerase. Synonyms: (4bS, 5aR)-12-cyclohexyl-N-(N, N-dimethylsulfamoyl)-3-methoxy-5a-((1R, 5S)-3-methyl-3, 8-diazabicyclo[3.2.1]octane-8-carbonyl)-4b, 5, 5a, 6-tetrahydrobenzo[3, 4]cyclopropa[5, 6]azepino[1, 2-a]indole-9-carboxamide hydrochloride; BMS791325; BMS-791325; BMS 791325. Grades: 99.87%. CAS No. 958002-33-0. Molecular formula: C36H45N5O5S. Mole weight: 659.84. | |
CBS, N-Cyclohexyl -2-benzothiazolesulfenami de Quick inquiry Where to buy Suppliers range | CBS, N-Cyclohexyl -2-benzothiazolesulfenami de . Group: Biochemicals. Grades: Highly Purified. CAS No. 95-33-0. Pack Sizes: 250g, 500g. US Biological Life Sciences. | Worldwide |
GDC-0941 Bimesylate Quick inquiry Where to buy Suppliers range | Potent inhibitor of Phosphatidylinositol 3-kinase (PI3K). Group: Biochemicals. Alternative Names: 2-(1H-Indazol-4-yl)-6-[[4-(methylsulfonyl)-1-piperazinyl]methyl]-4-(4-morpholinyl)thieno[3,2-d]pyrimidine Methanesulfonate. Grades: Highly Purified. CAS No. 957054-33-0. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
GDC-0941 dimethanesulfonate Quick inquiry Where to buy Suppliers range | GDC-0941 dimethanesulfonate is a potent inhibitor of PI3Kα/δ with modest selectivity against p110β and p110&gamma. It is a novel selective class I phosphatidylinositol-3-kinase (PI3K) inhibitor. It is designed to bind the ATP-binding pocket of PI3K and to prevent formation of phosphatidylinositol-3, 4, 5-triphosphate (PIP3), a second messenger that transmits PI3K downstream signals. It causes growth inhibition in a variety of cancer cell lines, including A2780, MDA-MB-361, PC3, and U87MG. It also inhibits the growth of trastuzumab-sensitive and -resistant HER2-amplied cancer cells which harbor p110( mutations or PTEN loss. It also reduces tumor volume in different xenograft models. Synonyms: GDC-0941 dimethanesulfonate; GDC 0941 dimethanesulfonate; GDC0941 dimethanesulfonate; Pictilisib dimethanesulfonate; GDC-0941 (2 MeSO3H salt). Grades: >98%. CAS No. 957054-33-0. Molecular formula: C25H35N7O9S4. Mole weight: 705.85. |