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| Product | Description | |
|---|---|---|
| Troglitazone | Troglitazone. Group: Biochemicals. Grades: Purified. CAS No. 97322-87-7. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. |  Worldwide |
| Troglitazone | Troglitazone is an orally active PPARγ agonist, with EC 50 s of 550 nM and 780 nM for human and murine?PPARγ receptor, respectively. Troglitazone has anticancer activity, prevents and inhibits the development of type 2 diabetes. Uses: Scientific research. Group: Signaling pathways. Alternative Names: CS-045. CAS No. 97322-87-7. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-50935. |  |
| Troglitazone | Troglitazone, PPARγ agonist, is an anti-diabetic thiazolidinedione (TZD) with anti-inflammatory and anti-tumor activity, which was approved for the treatment of insulin resistance and hyperglycemia in Type II diabetes, but was withdrawn from the market due to hepatotoxicity. It binds to the PPARγ ligand-binding domain (LBD) but fails to induce interaction of the PPARγ LBD with the transcriptional coactivators SRC-1, TIF2, AIB1, p300, or TRAP220. It also induces cell cycle arrest and apoptosis in several cancer cell lines. It displays no activity at PPARα or PPARδ receptors and displays anti-invasive effect on human breast cancer cells. It also inhibits cell growth of hematopoietic cell lines and inhibits lamellipodia formation and actin polymerization. Uses: Hypoglycemic agents. Synonyms: CI-991; CI991; CI 991; CS-045; CS 045; CS045; GR 92132X; GR92132X; Prelay; Troglitazone; Rezulin, Resulin, Romozin, Noscal. Grades: >98%. CAS No. 97322-87-7. Molecular formula: C24H27NO5S. Mole weight: 441.54. |  |
| Troglitazone (5-[[4-[(3,4-Dihydro-6-hydroxy-2,5,7,8-tetramethyl-2H-1-benzopyran-2-yl)methoxy]-phenyl]methyl]-2,4-thiazolidinedione, Romglizone, CS-045, CI-991,Noscal,) | An oral hypoglycemic agent which improves insulin sensitivity and decreases hepatic glucose production. Group: Biochemicals. Alternative Names: 5-[[4-[(3,4-Dihydro-6-hydroxy-2,5,7,8-tetramethyl-2H-1-benzopyran-2-yl)methoxy]-phenyl]methyl]-2,4-thiazolidinedione, Romglizone, CS-045, CI-991,Noscal. Grades: Highly Purified. CAS No. 97322-87-7. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| Troglitazone ((±)-5-[4-[(6-Hydroxy-2,5,7,8-tetramethylchroman-2-yl)methoxy]benzyl]-2,4-thiazolidinedione) | An antidiabetic thiazolidinedione (TDZ) drug with anti-inflammatory and anti-tumor activities. A potent and selective PPARγ agonist. The EC50 values for transactivation of human and murine PPARγ in a cell-based assay are 0.55 and 0.78uM, respectively. Group: Biochemicals. Alternative Names: (±)-5-[4-[(6-Hydroxy-2,5,7,8-tetramethylchroman-2-yl)methoxy]benzyl]-2,4-thiazolidinedione. Grades: Highly Purified. CAS No. 97322-87-7. Pack Sizes: 5mg. US Biological Life Sciences. | Worldwide |
| Troglitazone (5-phenyl]methyl]-2,4-thiazolidinedione, Romglizone, BRN 4338399, CS-045, CI-991, GR 92132X) | Potent and selective PPARgamma agonist with no activation of PPARalpha and PPARdelta. Anti-diabetic agent with potent glucose-lowering effects and decreasing insulin resistance in adipose tissues. Stimulates adipogenesis. Apoptosis and cell cycle arrest inducer in several cancer cell lines. Anti-inflammatory. Inhibits vascular smooth muscle cell (VSMC) migration. Group: Biochemicals. Alternative Names: 5-phenyl]methyl]-2,4-thiazolidinedione, Romglizone, BRN 4338399, CS-045, CI-991, GR 92132X. Grades: Highly Purified. CAS No. 97322-87-7. Pack Sizes: 5mg. US Biological Life Sciences. | Worldwide |
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