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| Product | Description | |
|---|---|---|
| A 438079 hydrochloride | A 438079 hydrochloride is a competitive P2X7 receptor antagonist with pIC50 value of 6.9 for the inhibition of Ca2+ influx in the human recombinant P2X7 cell line. It protects against acetaminophen-induced liver injury by inhibiting p450 isoenzymes, but not by inflammasome activation. It partially but significantly prevented the 6-OHDA-induced depletion of striatal DA stores. Synonyms: 3-[[5-(2,3-Dichlorophenyl)-1H-tetrazol-1-yl]methyl]pyridine hydrochloride;A-438079 HCl;A-438079 hydrochloride; A438079 hydrochloride; A 438079 hydrochloride. Grades: >98 %. CAS No. 899507-36-9. Molecular formula: C13H10Cl3N5. Mole weight: 342.61. |  |
| A 438079 hydrochloride | A 438079 (hydrochloride) is a potent, and selective P2X 7 receptor antagonist with pIC 50 of 6.9. Uses: Scientific research. Group: Signaling pathways. CAS No. 899431-18-6. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-15488A. |  |
| A 438079 hydrochloride | Competitive P2X7 receptor antagonist (pIC50 = 6.9 for the inhibition of Ca2+ influx in the human recombinant P2X7 cell line). Devoid of activity at other P2 receptors (IC50 >> 10 μM). Possesses antinociceptive activity in models of neuropathic pain in vivo. Inhibits methamphetamine-induced microglial migration and phagocytosis in vitro. Group: Biochemicals. Alternative Names: 3-[[5-(2,3-Dichlorophenyl)-1H-tetrazol-1-yl]methyl]pyridine Monohydrochloride; 3-[[5-(2,3-Dichlorophenyl)-1H-tetrazol-1-yl]methyl]pyridine Monohydrochloride; A 438079. Grades: Highly Purified. CAS No. 899431-18-6. Pack Sizes: 10mg, 25mg. Molecular Formula: C??H??Cl?N?, Molecular Weight: 342.61. US Biological Life Sciences. |  Worldwide |
| A 438079 | A potent, competitive, and selective antagonist of P2X7 purinergic receptor (pIC50 = 6.5nM and 6.9nM for rat and human P2X7 receptor, respectively). Shown to reduce ATP-induced reactive oxygen species formation in MEL cells by about 87% (~10uM) and blocks BzATP-stimulated changes in intracellular calcium concentrations (IC50 = 100 and 300nM at rat and human P2X7 receptors, respectively. Developed by Abbott. Group: Biochemicals. Alternative Names: 3-((5-(2,3-dichlorophenyl)-1H-tetrazol-1-yl)methyl)pyridine Hydrochloride; P2X7 Purinergic Receptor Antagonist; A 438079; A438079; A-438079. Grades: Highly Purified. CAS No. 899507-36-9. Pack Sizes: 10mg. Molecular Formula: C??H?Cl?N? HCl, Molecular Weight: DMSO. US Biological Life Sciences. | Worldwide |
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