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| Product | Description | |
|---|---|---|
| A-971432 | ?95% (HPLC). Group: Fluorescence/luminescence spectroscopy. |  |
| A-971432 | A-971432 is a potent, selective and orally active sphingosine-1-phosphate (S1P) receptor 5 agonist with IC 50 s of.362, >10, 0.006 μM for S1P1, S1P3, S1P5 respectively. A-971432 protects blood - brain barrier (BBB) homeostasis. A-971432 reverses age-related cognitive decline. A-971432 has the potential for the research of alzheimers disease or multiple sclerosis [1] [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1240308-45-5. Pack Sizes: 1 mg; 5 mg. Product ID: HY-110291. |  |
| A-971432 | This active molecular is a selective S1P5 (Sphingosine-1-Phosphate Receptor 5) agonist originated by AbbVie for the treatment of neurodegenerative disorders. A 971432 is highly selective for S1P5 with IC50 value of 6 nM for S1P5, 362 nM for S1P1 and >10 μM for S1P3. A 971432 improves blood-brain barrier integrity in an in vitro model and reverses age-related cognitive decline in mice. S1P5 agonists have been reported as an innovative mechanism for the treatment of neurodegenerative disorders including Alzheimer's disease and lysosomal storage disorders such as Niemann-Pick disease. Uses: Neurodegenerative disorder;lysosomal storage disorders. Synonyms: A971432; A 971432; 1-(4-((3,4-Dichlorobenzyl)oxy)benzyl)azetidine-3-carboxylic Acid. Grade: 95%. CAS No. 1240308-45-5. Molecular formula: C18H17Cl2NO3. Mole weight: 366.24. |  |
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