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| Product | Description | |
|---|---|---|
| ABT-100 | ABT-100 is an orally bioavailable farnesyltransferase inhibitor. ABT-100 inhibited proliferation of cells in vitro carrying oncogenic H-Ras (EJ-1 bladder; IC(50) 2.2 nmol/L), Ki-Ras (DLD-1 colon, MDA-MB-231 breast, HCT-116 colon, and MiaPaCa-2 pancreatic; IC(50) range, 3.8-9.2 nmol/L), and wild-type Ras (PC-3 and DU-145; IC(50), 70 and 818 nmol/L, respectively) as well as clonogenic potential. ABT-100 shows 70% to 80% oral bioavailability in mice. ABT-100 regressed EJ-1 tumors (2-12.5 mg/kg/d s.c., every day for 21 days) and showed significant efficacy in DLD-1, LX-1, MiaPaCa-2, or PC-3 tumor-bearing mice (6.25-50 mg/kg/d s.c. once daily or twice daily orally). Uses: Designed for use in research and industrial production. Additional or Alternative Names: ABT100; ABT 100; ABT-100; A367074; A 367074; A-367074. Product Category: Inhibitors. Appearance: White solid powder. CAS No. 450839-40-4. Molecular formula: C27H19F3N4O3. Mole weight: 504.46. Purity: >98%. IUPACName: (S)-6-(2-(4-cyanophenyl)-2-hydroxy-2-(1-methyl-1H-imidazol-5-yl)ethoxy)-4'-(trifluoromethoxy)-[1,1'-biphenyl]-3-carbonitrile. Canonical SMILES: N#CC1=CC(C2=CC=C(OC(F)(F)F)C=C2)=C(OC[C@](O)(C3=CC=C(C#N)C=C3)C4=CN=CN4C)C=C1. Product ID: ACM450839404. Alfa Chemistry ISO 9001:2015 Certified. Categories: AB-1001. |  |
| ABT-100 | ABT-100 is an orally bioavailable farnesyltransferase inhibitor. ABT-100 inhibits cell proliferation (IC50s of 2.2 nM, 3.8 nM, 5.9 nM, 6.9 nM, 9.2 nM, 70 nM and 818 nM for EJ-1, DLD-1, MDA-MB-231, HCT-116, MiaPaCa-2, PC-3, and DU-145 cells, respectively), increases apoptosis and decreases angiogenesis. ABT-100 possesses broad-spectrum antitumor activity. Synonyms: ABT 100; ABT100; A-367074; A 367074; A367074. Grades: >98%. CAS No. 450839-40-4. Molecular formula: C27H19F3N4O3. Mole weight: 504.47. |  |
| ABT-100 | ABT-100 is a potent, highly selective and orally active farnesyltransferase inhibitor. ABT-100 inhibits cell proliferation ( IC 50 s of 2.2 nM, 3.8 nM, 5.9 nM, 6.9 nM, 9.2 nM, 70 nM and 818 nM for EJ-1, DLD-1, MDA-MB-231, HCT-116, MiaPaCa-2, PC-3, and DU-145 cells, respectively), increases apoptosis and decreases angiogenesis. ABT-100 possesses broad-spectrum antitumor activity [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 450839-40-4. Pack Sizes: 5 mg. Product ID: HY-119257. |  |
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