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| Product | Description | |
|---|---|---|
| ABT-737 | ABT-737, a BH3 mimetic, is a potent Bcl-2 , Bcl-x L and Bcl-w inhibitor with EC 50 s of 30.3 nM, 78.7 nM, and 197.8 nM, respectively. ABT-737 induces the disruption of the BCL-2/BAX complex and BAK-dependent but BIM-independent activation of the intrinsic apoptotic pathway. ABT-737 induces autophagy and has the potential for acute myeloid leukemia (AML) research [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. CAS No. 852808-04-9. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg; 200 mg. Product ID: HY-50907. |  |
| ABT-737 | ABT-737 is a potent, cell-permeable mimetic of BH3 domains that avidly binds Bcl-2, Bcl-xL, and Bcl-W (Ki < 1 nM for all three proteins). It blocks the interaction of these proteins with pro-death proteins, leading to apoptosis. Synonyms: ABT 737; ABT-737; ABT737. CAS No. 852808-04-9. Molecular formula: C42H45ClN6O5S2. Mole weight: 813.43. |  |
| ABT 737 | A selective inhibitor of BCL-2, in small cell lung cancer. ABT-737 induced dramatic regressions in tumors derived from some SCLC cell lines. Group: Biochemicals. Alternative Names: 4- [4- [ (4-Chloro [1, 1-biphenyl] -2-yl) methyl] -1-piperazinyl] -N- [ [4- [ [ (1R) -3- (dimethylamino) -1- [ (phenylthio) methyl] propyl] amino] -3-nitrophenyl] sulfonyl] benzamide. Grades: Highly Purified. CAS No. 852808-04-9. Pack Sizes: 5mg. US Biological Life Sciences. |  Worldwide |
| ABT 737-[d8] | Labelled ABT-737. ABT-737 is a potent, cell-permeable mimetic of BH3 domains that avidly binds Bcl-2, Bcl-xL, and Bcl-W (Ki < 1 nM for all three proteins). It blocks the interaction of these proteins with pro-death proteins, leading to apoptosis. Synonyms: 4-[4-[(4'-Chloro[1,1'-biphenyl]-2-yl)methyl]-1-piperazinyl]-N-[[4-[[(1R)-3-(dimethylamino)-1-[(phenylthio)methyl]propyl]amino]-3-nitrophenyl]sulfonyl]benzamide-d8. CAS No. 1217686-68-4. Molecular formula: C42H37D8ClN6O5S2. Mole weight: 821.48. | |
| ABT 737-d8 | A selective inhibitor of BCL-2, in small cell lung cancer. ABT-737 induced dramatic regressions in tumors derived from some SCLC cell lines. Group: Biochemicals. Alternative Names: 4- [4- [ (4-Chloro [1, 1-biphenyl] -2-yl) methyl] -1-piperazinyl] -N- [ [4- [ [ (1R) -3- (dimethylamino) -1- [ (phenylthio) methyl] propyl] amino] -3-nitrophenyl] sulfonyl] benzamide-d8. Grades: Highly Purified. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
| Mcl-1 Inhibitor, MIM1 (4-((E)-((Z)-2-(cyclohexylimino)-4-methylthiazol-3(2H)-ylimino)methyl)benzene-1,2,3-triol, Mcl-1 Inhibitor Molecule 1) | A cell-permeable thiazolyl iminopyrogallol that selectively neutralizes Mcl-1, but not Bcl-XL, antiapoptotic activity by directly targeting Mcl-1 BH3-binding site, effectively competing against Bid BH3 sequence for Mcl-1 binding (IC50 = 4.8uM). Shown to induce caspase 3/7 activation and cell death in Mcl-1-, but not Bcl-XL-, dependent B-ALL cultures (6% vs. 82% survival, respectively; 10uM). In comparison, ABT-737 affects only Bcl-XL-, but not Mcl-1-, dependent B-ALL cells. Neither MIM1 nor ABT-737 significantly affects the survival of wild-type or Bax-/-Bak-/- MEF. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 25mg. Molecular Formula: C??H??N?O?S. US Biological Life Sciences. | Worldwide |
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