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| Product | Description | |
|---|---|---|
| Acolbifene | Acolbifene, also known as EM-652, or SCH-57068, is a selective estrogen receptor modulator (SERM). Acolbifene is currently being studied in the prevention of breast cancer in women at high risk of breast cancer. EM-652 is the compound having the highest affinity for the estrogen receptor, including estradiol. It has higher affinity for the ER than ICI 182780, hydroxytamoxifen, raloxifene, droloxifene and hydroxytoremifene. EM-652 was also the most potent inhibitor of the percentage of cycling cancer cells. Synonyms: EM-652; SCH 57068; (2S)-3-(4-Hydroxyphenyl)-4-methyl-2-[4-[2-(1-piperidinyl)ethoxy]phenyl]-2H-1-benzopyran-7-ol; (S)-3-(4-Hydroxyphenyl)-4-methyl-2-[4-[2-(1-piperidinyl)ethoxy]phenyl]-2H-1-benzopyran-7-ol; (S)-3-(4-hydroxyphenyl)-4-methyl-2-(4-(2-(piperidin-1-yl)ethoxy)phenyl)-2H-chromen-7-ol. Grade: ≥98%. CAS No. 182167-02-8. Molecular formula: C29H31NO4. Mole weight: 457.57. |  |
| Acolbifene | Acolbifene (EM-652), the active metabolite of EM800, is an orally active pure antiestrogen and selective estrogen receptor antagonist. Acolbifene (EM-652) inhibits estradiol (E2)-induced transcriptional activity of ERα (IC 50 = 2 nM) and ERβ (IC 50 = 0.4 nM). Acolbifene (EM-652) possesses potent and pure anticarcinogenic properties [1] [2] [3] [4] [5]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: EM-652; SCH 57068. CAS No. 182167-02-8. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg. Product ID: HY-16023A. |  |
| Acolbifene hydrochloride | Acolbifene (EM-652) hydrochloride, an active metabolite of EM800, is an orally active, cancer-preventing selective estrogen receptor modulator (SERM). Acolbifene (EM-652) hydrochloride inhibits estradiol (E2)-induced transcriptional activity of ERα (IC 50 =2 nM) and ERβ (IC 50 =0.4 nM). Acolbifene (EM-652) hydrochloride exerts a potent and pure antiestrogenic action in the mammary gland and uterus. Anticarcinogenic properties [1] [2] [3] [4] [5]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: EM-652 hydrochloride; SCH 57068 hydrochloride. CAS No. 252555-01-4. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-16023. | |
| Acolbifene hydrochloride | Acolbifene hydrochloride, an active metabolite of EM800, is an orally active selective estrogen receptor modulator (SERM) with anticarcinogenic properties. It has a potent and pure antiestrogenic effect on mammary gland and uterus, and inhibits estradiol (E2)-induced transcriptional activity of ERα and ERβ with IC50s of 2 and 0.4 nM, respectively. Synonyms: EM-652 hydrochloride; SCH 57068 hydrochloride; 2H-1-Benzopyran-7-ol, 3-(4-hydroxyphenyl)-4-methyl-2-(4-(2-(1-piperidinyl)ethoxy)phenyl)-, hydrochloride, (2S)-; (S)-3-(4-Hydroxyphenyl)-4-methyl-2-(4-(2-(piperidin-1-yl)ethoxy)phenyl)-2H-chromen-7-ol hydrochloride. Grade: ≥98%. CAS No. 252555-01-4. Molecular formula: C29H32ClNO4. Mole weight: 494.02. | |
| (Rac)-Acolbifene | (Rac)-Acolbifene, the racemic form of EM652 (estrogen receptor antagonist), has anti-estrogenic and estrogenic activities. It has an inhibitory effect in T-47D cells with an IC50 of 0.110 nM. Synonyms: EM-343; (Rac)-EM-652; 3-(4-Hydroxyphenyl)-4-methyl-2-[4-[2-(1-piperidinyl)ethoxy]phenyl]-2H-1-benzopyran-7-ol; 2H-1-Benzopyran-7-ol, 3-(4-hydroxyphenyl)-4-methyl-2-[4-[2-(1-piperidinyl)ethoxy]phenyl]-. Grade: ≥95%. CAS No. 151533-34-5. Molecular formula: C29H31NO4. Mole weight: 457.56. | |
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