Acyltransferase Suppliers USA
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Product | Description | |
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1,3-Dipalmitoyl-rac-glycerol Quick inquiry Where to buy Suppliers range | 1,3-Dipalmitoyl-rac-glycerol is a diacylglycerol that contains palmitic acid at the sn-1 and sn-3 positions. It activates protein kinase C α (PKCα) in vitro (Ka = 3.8 μM). 1,3-Dipalmitoyl-rac-glycerol (0.25-2 μM) inhibits apoptosis and production of reactive oxygen species (ROS) and pro-inflammatory mediators induced by oxygen-glucose deprivation and reperfusion (OGD/R) in SH-SY5Y neuroblastoma cells. An acyl acceptor for the unspecific bifunctional wax ester synthase/acyl-CoA:Diacylglycerol acyltransferase. Synonyms: 1,3-Dipalmitin; Dipalmitin; 1,3-Dipalmitoyl-glycerol; Glyceryl 1,3-dipalmitate. Grades: ≥98%. CAS No. 502-52-3. Molecular formula: C35H68O5. Mole weight: 568.91. | |
14-Pentadecynoic Acid Quick inquiry Where to buy Suppliers range | 14-Pentadecynoic Acid is a reagent in the study of palmitoylation by the hedgehog acyltransferase. Group: Biochemicals. Grades: Highly Purified. CAS No. 212913-84-3. Pack Sizes: 10mg, 25mg. Molecular Formula: C15H26O2, Molecular Weight: 238.37. US Biological Life Sciences. | Worldwide |
1-tert-Butyl 3-Methyl 5-Hydroxypiperidine-1,3-dicarboxylate Quick inquiry Where to buy Suppliers range | 1-tert-Butyl 3-Methyl 5-Hydroxypiperidine-1,3-dicarboxylate is an intermediate used in the synthesis of heterocyclyl aminopyrazine derivatives for use as CHK-1 inhibitors. It is also used to prepare pyrrolidinyl imidazopyridinyl piperidinyl methanone derivatives and analogs for use as diacylglycerol acyltransferase 2 inhibitors. Group: Biochemicals. Grades: Highly Purified. CAS No. 1095010-47-1. Pack Sizes: 50mg, 250mg. Molecular Formula: C12H21NO5, Molecular Weight: 259.3. US Biological Life Sciences. | Worldwide |
2-((4-Oxo-3-phenyl-3,4,6,7-tetrahydrothieno[3,2-d]pyrimidin-2-yl)thio)-N-(5-phenylpyridin-2-yl)acetamide Quick inquiry Where to buy Suppliers range | 2-((4-Oxo-3-phenyl-3,4,6,7-tetrahydrothieno[3,2-d]pyrimidin-2-yl)thio)-N-(5-phenylpyridin-2-yl)acetamide is an inhibitor of Porcupine, a member of the membrane-bound O-acyltransferase family of proteins. Group: Biochemicals. Grades: Highly Purified. CAS No. 1427782-89-5. Pack Sizes: 5mg, 10mg. Molecular Formula: C25H20N4O2S2, Molecular Weight: 472.58. US Biological Life Sciences. | Worldwide |
2,6-Dichlorophenylacetic Acid Quick inquiry Where to buy Suppliers range | 2,6-Dichlorophenylacetic Acid is an impurity of Guanfacine, which is an α2A receptor selective agonist used to treat attention deficit hyperactivity disorder (ADHD) and hypertension. Uses: 2,6-dichlorophenylacetic acid is an inhibitor of isopenicillin n synthase (ipns) and acyl-coa: 6-apa acyltransferase. 2,6-dichlorophenylacetic acid is also part of a group of phenylacetate derivatives that have cytostatic activity against tumour cells. Synonyms: 2,6-Dichlorobenzeneacetic Acid; Guanfacine Impurity 1; Benzeneacetic acid, 2,6-dichloro-. Grades: ≥95%. CAS No. 6575-24-2. Molecular formula: C8H6Cl2O2. Mole weight: 205.04. | |
2-Bromopropionyl Chloride Quick inquiry Where to buy Suppliers range | 2-Bromopropionyl chloride is a reagent that is used in the preparation of pyrazinecarboxamide-based inhibitors of diacylglycerol acyltransferase 1. Group: Biochemicals. Grades: Highly Purified. CAS No. 7148-74-5. Pack Sizes: 1g, 10g. Molecular Formula: C3H4BrClO, Molecular Weight: 171.42. US Biological Life Sciences. | Worldwide |
2-Stearoyl-d35-sn-glycero-3-phosphocholine Quick inquiry Where to buy Suppliers range | 2-Stearoyl-d35-sn-glycero-3-phosphocholine is labelled 2-Stearoyl-sn-glycero-3-phosphocholine (S686575) which is a fatty acid that when in complex acyl-CoA acts as an Acyltransferase enzyme. Found in mice after exposure to endocrine disruptors DEHP and Aroclor 1254. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 1mg, 2.5mg. Molecular Formula: C26H19D35NO7P, Molecular Weight: 558.9. US Biological Life Sciences. | Worldwide |
(3S,6R)-Lateritin Quick inquiry Where to buy Suppliers range | N-methylated peptide that is structurally equivalent to a monomer of beauvericin. Acyl-CoA:cholesterol acyltransferase inhibitor. Platelet aggregation inhibitor. Antimicrobial. Note: The (3R,6R)-stereoisomer was shown to have anti-cancer and apoptosis inducing activity. Group: Biochemicals. Grades: Highly Purified. CAS No. 65454-13-9. Pack Sizes: 1mg. Molecular Formula: C15H19NO3. US Biological Life Sciences. | Worldwide |
4-Benzyloxy-2-nitrophenol Quick inquiry Where to buy Suppliers range | 4-Benzyloxy-2-nitrophenol is used for the preparation of novel anilide compounds as acyl CoA cholesterol acyltransferase inhibitors. Group: Biochemicals. Alternative Names: 2-Nitro-4-(phenylmethoxy)phenol; 4-(Benzyloxy)-2-nitrophenol; 2-Nitro-4-(benzyloxy)phenol; 2-Nitro-4-(phenylmethoxy)phenol. Grades: Highly Purified. CAS No. 96315-18-3. Pack Sizes: 250mg. US Biological Life Sciences. | Worldwide |
A922500 Quick inquiry Where to buy Suppliers range | A922500 is an inhibitor for human and mouse DGAT-1 with IC50 of 7 nM and 24 nM, respectively, good selectivity over related acyltransferases, hERG, and a panel of anti-targets. Synonyms: A922500; A 922500; A-922500. Grades: >98%. CAS No. 959122-11-3. Molecular formula: C26H24N2O4. Mole weight: 428.48. | |
ABT-046 Quick inquiry Where to buy Suppliers range | ABT-046 is a potent, selective, and orally bioavailable Diacylglycerol acyltransferase 1 (DGAT-1 ) inhibitor (IC50=8 nM). Synonyms: ABT-046; ABT 046; ABT046. Grades: >98%. CAS No. 1031336-60-3. Molecular formula: C20H22N4O2. Mole weight: 350.41. | |
AS-186c Quick inquiry Where to buy Suppliers range | AS-186c is an acyl-CoA: cholesterol acyltransferase (ACAT) inhibitor produced by Penicillum asperosporum KY1635. The IC50 for inhibiting ACAT was 11.5 μmol/L. Synonyms: 1-(7-{2-[2,6-dihydroxy-3-(3-methylbut-2-en-1-yl)benzoyl]-3-hydroxy-5-methylphenyl}-8,12-dihydroxy-4-methoxy-10-methyl-5-oxo-7,8-dihydro-5H-dibenzo[b,h][1,5]dioxonin-3-yl)-3-methylbutyl acetate. Molecular formula: C43H46O12. Mole weight: 754.82. | |
AS-186d Quick inquiry Where to buy Suppliers range | AS-186d is an acyl-CoA: cholesterol acyltransferase (ACAT) inhibitor produced by Penicillum asperosporum KY1635. The IC50 for inhibiting ACAT was 12.4 μmol/L. Synonyms: 1-(8,12-dihydroxy-7-{3-hydroxy-2-[6-hydroxy-3-(1-hydroxy-3-methylbutyl)-2-methoxybenzoyl]-5-methylphenyl}-4-methoxy-10-methyl-5-oxo-7,8-dihydro-5H-dibenzo[b,h][1,5]dioxonin-3-yl)-3-methylbutyl acetate. Molecular formula: C44H50O13. Mole weight: 786.86. | |
AZD 3988 Quick inquiry Where to buy Suppliers range | AZD 3988 is a selective and potent diacylglycerol O-acyltransferase (DGAT) enzyme inhibitor with IC50 value of 0.6 nM. It is selective for DGAT-1 over DGAT-2, cytochrome P450 enzymes and Kv11.1 (hERG). It suppresses adipose tissue TAG synthesis and triacylglyceride (TAG) plasma excursion in rats. It reduces body weight of diet-induced obese rats and may be used as a potential treatment for diabetes and other metabolic diseases. It is orally bioavailable and cell permeable. Synonyms: AZD 3988; AZD-3988; AZD3988; trans-4- [- [ [ [5- [ (3, 4-Difluorophenyl) amino] -1, 3, 4-oxadiazol-2-yl] carbonyl] amino] phenyl] cyclohexaneacetic acid. Grades: ≥98% by HPLC. CAS No. 892489-52-0. Molecular formula: C23H22F2N4O4. Mole weight: 456.44. | |
Beauvericin Quick inquiry Where to buy Suppliers range | Beauvericin is a cyclic depsipeptide isolated from several fungal genera, notably Beauveria and Fusarium, first reported in 1969. Beauvericin exhibits broad antifungal, antibacterial, antiprotozoan and insecticidal activities. At the molecular level, beauvericin has been shown to exhibit ionophoric properties and inhibits acyl- CoA:cholesterol acyltransferase activity. Beauvericin induces apoptosis by elevating intracellular calcium levels. Group: Biochemicals. Grades: Highly Purified. CAS No. 26048-05-5. Pack Sizes: 5mg. US Biological Life Sciences. | Worldwide |
Beauvericin Quick inquiry Where to buy Suppliers range | Beauvericin is produced by the strain of Streptomyces sp. Ba cyclic depsipeptide isolated from several fungal genera, notably beauveria and fusarium; exhibits broad antifungal, antibacterial, antiprotozoan and insecticidal activities; exhibits ionophoric properties, and inhibits acyl-coa:Cholesterol acyltransferase activity; induces apoptosis by elevating intracellular calcium levels. Synonyms: Cyclo(-D-alpha-hydroxyisovaleryl-N-Me-Phe)3. Grades: >97% by HPLC. CAS No. 26048-05-5. Molecular formula: C45H57N3O9. Mole weight: 783.95. | |
Cochlioquinone A (Luteoleersin) Quick inquiry Where to buy Suppliers range | Cochlioquinone A is the major component of a bioactive pigment isolated from Bipolaris leersia. Cochlioquinone A has been recently shown to be an antagonist of the human chemokine receptor CCR5 in human immunodeficiency virus type 1 (HIV-1). It is anti-angiogenic and exhibits inhibitory activity against diacylglycerol acyltransferase and NADH-ubiquinone reductase. Group: Biochemicals. Alternative Names: Luteoleersin. Grades: Highly Purified. CAS No. 32450-25-2. Pack Sizes: 500ug. US Biological Life Sciences. | Worldwide |
Cochlioquinone B Quick inquiry Where to buy Suppliers range | It is the minor component of a bioactive pigment isolated from Bipolaris cynodontis and Cochliobolus miyabeanus. It is an NADH-ubiquinone reductase inhibitor. It is also a phytotoxic agent inhibiting root growth. It is closely related to cochlioquinone A which inhibits diacylglycerol acyltransferase and exhibits anti-angiogenic and nematocidal activity. It is an antagonist of the human chemokine receptor, CCR5, in HIV-1. Synonyms: 20-De(acetyloxy)-11-deoxy-20-oxo-cochlioquinone A; 9-(1, 3-Dimethyl-2-oxopentyl)-1, 2, 3, 4aα, 5, 6, 6a, 12, 12aα, 12b-decahydro-3β-(1-hydroxy-1-methylethyl)-6aβ, 12bβ-dimethyl-pyrano[3, 2-a]xanthene-8, 11-dione Stereoisomer; (3R,4aR,6aR,12aR,12bR)-9-[(1S,3S)-1,3-Dimethyl-2-oxopentyl]-1,2,3,4a,5,6,6a,12,12a,12b-decahydro-3-(1-hydroxy-1-methylethyl)-6a,12b-dimethylpyrano[3,2-a]xanthene-8,11-dione. Grades: >99% by HPLC. CAS No. 32450-26-3. Molecular formula: C28H40O6. Mole weight: 472.61. | |
Cochlioquinone B Quick inquiry Where to buy Suppliers range | Cochlioquinone B, the minor component of a bioactive pigment isolated from Bipolaris leersia, is an NADH-ubiquinone reductase inhibitor and a phytotoxic agent inhibiting root growth. It is closely related to Cochlioquinone A that inhibits diacylglycerol acyltransferase and exhibits anti-angiogenic and nematocidal activity. Cochlioquinones have been recently shown to be antagonists of the human chemokine receptor CCR5 in human immunodeficiency virus type 1 (HIV-1). Group: Biochemicals. Grades: Highly Purified. CAS No. 32450-26-3. Pack Sizes: 500ug. US Biological Life Sciences. | Worldwide |
Cyclandelate Quick inquiry Where to buy Suppliers range | Cyclandelate is an effective inhibitor of rat hepatic acycloenzyme A: cholesterol acyltransferase (ACAT) with IC50 of 80 μM. Uses: Vasodilator agents. Synonyms: BS 572; BS572; BS-572. Grades: >98%. CAS No. 456-59-7. Molecular formula: C17H24O3. Mole weight: 276.37. | |
DGAT1-IN-1 Quick inquiry Where to buy Suppliers range | Imidazopyridine and imidazothiazole compounds as inhibitors of diacylglycerol o-acyltransferase type 1 enzyme and their preparation. Synonyms: DGAT1-IN-1; DGAT1 IN 1. Grades: >98%. CAS No. 1449779-49-0. Molecular formula: C30H28F3N3O4. Mole weight: 551.56. | |
Eldacimibe Quick inquiry Where to buy Suppliers range | Eldacimibe is a Sterol O-acyltransferase inhibitor originated by Wyeth. No development was reported for Atherosclerosis and Hypercholesterolaemia in USA. Uses: Atherosclerosis; hypercholesterolaemia. Synonyms: ACA 147; ANA 147; WAY 125147; WAY ACA 147; 1,3-Dioxane-4,6-dione, 5-(((3,5-bis(1,1-dimethylethyl)-4-hydroxyphenyl)amino)(((4-(2,2-dimethylpropyl)phenyl)-methyl)hexylamino)methylene-2,2-dimethyl. Grades: 98%. CAS No. 141993-70-6. Molecular formula: C39H58N2O5. Mole weight: 634.89. | |
Enniatin F Quick inquiry Where to buy Suppliers range | It is produced by the strain of Fusarium orthoceras var. enniatinum. It has insecticidal and antifungal activity, and it also can inhibit Acylcoa, cholesterol acyltransferase (ACAT). Synonyms: Enniatin A, 2-(N-methyl-L-leucine)-; Cyclo(hiv-Me-leu-hiv-Me-ile-hiv-Me-ile). CAS No. 144446-20-8. Molecular formula: C36H63N3O9. Mole weight: 681.90. | |
Epi-cochlioquinone A Quick inquiry Where to buy Suppliers range | It is produced by the strain of Stachybitrys bisbyi. It can inhibit rat liver microsomal ACAT with IC50 of 1.7 μmol/L, inhibit plasma lecithin cholesterol acyltransferase (LCAT) with IC50 of 15.8 μmol/L, and inhibit cholesterol absorption in rats by 50% at 75 mg/kg. Synonyms: Epicochlioquinone A; (8-alpha)-Cochlioquinone A; Cochlioquinone A, (8-alpha)-. CAS No. 147384-57-4. Molecular formula: C30H44O8. Mole weight: 532.67. | |
Ethyl Isobutyrylacetate Quick inquiry Where to buy Suppliers range | Ethyl Isobutyrylacetate is used in the synthesis of piperazine derivatives as possible multireceptor atypical antipsychotics, affecting dopamine and serotonin receptor properties. Also used in the synthesis of pyrazinecarboxamide DGAT1 (diacylglycerol acyltransferase 1) inhibitors used in the treatment of obesity. Group: Biochemicals. Alternative Names: 3-Oxo-4-methylpentanoic Acid Ethyl Ester; 4-Methyl-3-oxo-pentanoic Acid Ethyl Ester; 4-Methyl-3-oxovaleric Acid Ethyl Ester; Ethyl 2-isobutyrylacetate; Ethyl 3-Isopropyl-3-oxopropanoate; Ethyl 3-oxo-4-methylpentanoate; Ethyl 3-Oxo-4-methylvalerate; Ethyl 4-Methyl-3-oxopentanoate; Ethyl 4-Methyl-3-oxovalerate; Ethyl Isobutyrylacetate; Isobutyrylacetic Acid Ethyl Ester; NSC 62029; γ,γ-Dimethylacetoacetic Acid Ethyl Ester; Ethyl 4-Methyl-3-oxopentanoate. Grades: Highly Purified. CAS No. 7152-15-0. Pack Sizes: 5g. US Biological Life Sciences. | Worldwide |
FR-182980 Quick inquiry Where to buy Suppliers range | FR-182980, a pyridine derivative, has been found to be a sterol O-acyltransferase inhibitor and was once studied in hypercholesterolaemia. Synonyms: FR-182980; FR182980; FR 182980; 1-cycloheptyl-1-[[4-(4-fluorophenoxy)phenyl]methyl]-3-[6-methyl-2,4-bis(methylsulfanyl)pyridin-3-yl]urea. Grades: 98%. CAS No. 179054-51-4. Molecular formula: C29H34FN3O2S2. Mole weight: 539.73. | |
FR-186054 Quick inquiry Where to buy Suppliers range | FR-186054, a pyridine derivative, has been found to be a sterol O-acyltransferase inhibitor and was once studied in hyperlipidaemia. Synonyms: FR-186054; FR 186054; FR186054; 1-benzyl-3-[6-methyl-2,4-bis(methylsulfanyl)pyridin-3-yl]-1-[[3-(1H-pyrazol-5-yl)phenyl]methyl]urea. Grades: 98%. CAS No. 179053-90-8. Molecular formula: C26H27N5OS2. Mole weight: 489.66. | |
Fumonisin B1 Quick inquiry Where to buy Suppliers range | Fumonisin B1 is produced by the strain of Gibberella fujikuroi and Fumarium moniliforme. It is a liver toxin, which can activate the cancer promoter and cause liver cancer. It has been reported that it is related to the occurrence of human esophageal cancer in South Africa and other places. It can also cause pig pulmonary edema, and is also the pathogenic substance of equine leukoencephalitis. Fumonisin B1 inhibits sphingosine acyltransferase. Synonyms: Macrofusine; Macrofusine; NSC 629151; (R)-3-Carboxy-pentanedioic acid mono-{(1S,3S,5R,10R,12S,13S)-13-amino-1-[(1R,2R)-1-((R)-3,4-dicarboxy-butyryloxy)-2-methyl-hexyl]-5,10,12-trihydroxy-3-methyl-tetradecyl} ester. Grades: ≥98%. CAS No. 116355-83-0. Molecular formula: C34H59NO15. Mole weight: 721.83. | |
Fumonisin B2 Quick inquiry Where to buy Suppliers range | Fumonisin B2 is a liver toxin produced by Gibberella fujikuroi and Fumarium moniliforme. It is more cytotoxic than fumonisin B1. Fumonisin B2 inhibits sphingosine acyltransferase. Uses: Carcinogens, environmental. Synonyms: 1,2,3-Propanetricarboxylic acid, 1,1'-(1-(12-amino-9,11-dihydroxy-2-methyltridecyl)-2-(1-methylpentyl)-1,2-ethanediyl) ester. Grades: >95%. CAS No. 116355-84-1. Molecular formula: C34H59NO14. Mole weight: 705.85. | |
Fumonisin B2 Quick inquiry Where to buy Suppliers range | A mycotoxin produced by mold associated with corn. Inhibitor of sphingosine N-acyltransferase. Blocks the formation of ceramide from sphingosine. Group: Biochemicals. Alternative Names: (2R,2'R)-1,2,3-Propanetricarboxylic Acid 1,1'-[(1S,2R)-1-[(2S,9R,11S,12S)-12-Amino-4,9,11-trihydroxy-2-methyltridecyl]-2-[(1R)-1-methylpentyl]-1,2-ethanediyl] Ester. Grades: Highly Purified. CAS No. 116355-84-1. Pack Sizes: 5mg. US Biological Life Sciences. | Worldwide |
Fumonisin B3 Quick inquiry Where to buy Suppliers range | Fumonisin B3 is a mycotoxin produced by Fusarium moniliforme which is the most commonly reported fungal species infecting maize. Fumonisins acts as an inhibitor of ceramide synthase (sphingosine N-acyltransferase). Synonyms: FB3; (2R,2'R)-2,2'-((((5R,6R,7S,9S,11R,18S,19S)-19-Amino-11,18-dihydroxy-5,9-dimethylicosane-6,7-diyl)bis(oxy))bis(2-oxoethane-2,1-diyl))disuccinic Acid. Grades: ≥98%. CAS No. 1422359-85-0. Molecular formula: C34H59NO14. Mole weight: 705.83. | |
Glisoprenin A Quick inquiry Where to buy Suppliers range | It is produced by the strain of Gliocladium sp. FO-1513. It is a cholesterol acyltransferase (ACAT) inhibitor, and it can inhibit the formation of Appressorium on the hydrophobic surface of Magnaporthegrisea. Synonyms: (+)-GlisopreninA; FO 1513A; 2,6,10,14,34-Hexatriacontapentaene-1,19,23,27,31-pentol,3,7,11,15,19,23,27,31,35-nonamethyl-. Grades: 95%. CAS No. 144376-62-5. Molecular formula: C45H82O5. Mole weight: 703.14. | |
Glisoprenin B Quick inquiry Where to buy Suppliers range | It is produced by the strain of Gliocladium sp. FO-1513. It is a cholesterol acyltransferase (ACAT) inhibitor. Synonyms: 2,6,10,14-Tricosatetraene-1,19,23,27-tetrol,3,7,11,15,19,23,27-heptamethyl-30-(tetrahydro-5-(1-hydroxy-1-methylethyl)-2-methyl-2-furanyl)-. CAS No. 144376-63-6. Molecular formula: C45H82O6. Mole weight: 719.13. | |
Glisoprenin C Quick inquiry Where to buy Suppliers range | It is produced by the strain of Gliocladium roseum HA190-95. It is a cholesterol acyltransferase (ACAT) inhibitor, and it can inhibit the formation of Appressorium on the hydrophobic surface of Magnaporthegrisea. CAS No. 205594-88-3. Molecular formula: C45H84O8. Mole weight: 753.14. | |
Glisoprenin D Quick inquiry Where to buy Suppliers range | It is produced by the strain of Gliocladium roseum HA190-95. It is a cholesterol acyltransferase (ACAT) inhibitor, and it can inhibit the formation of Appressorium on the hydrophobic surface of Magnaporthegrisea. Molecular formula: C45H84O7. Mole weight: 737.14. | |
Glisoprenin E Quick inquiry Where to buy Suppliers range | It is produced by the strain of Gliocladium roseum HA190-95. It is a cholesterol acyltransferase (ACAT) inhibitor, and it can inhibit the formation of Appressorium on the hydrophobic surface of Magnaporthegrisea. Molecular formula: C45H86O9. Mole weight: 771.16. | |
Glycerol-d5 1,3-Dipalmitate Quick inquiry Where to buy Suppliers range | A glycidol fatty acid esters in edible oils. An acyl acceptor for the unspecific bifunctional wax ester synthase/acyl-CoA:Diacylglycerol acyltransferase. Group: Biochemicals. Alternative Names: 1,3-Dipalmitin-d5; 1,3-Dipalmitoylglycerin-d5; 1,3-Dipalmitoylglycerol-d5; Glycerol-d5 1,3-Dihexadecanoate; Hexadecanoic-d5 Acid 2-Hydroxy-1,3-propanediyl Ester. Grades: Highly Purified. CAS No. 65615-82-9. Pack Sizes: 5mg. US Biological Life Sciences. | Worldwide |
Gypsetin Quick inquiry Where to buy Suppliers range | It is produced by the strain of Nannizzia gypsea var. incurvata IFO 9228. It can inhibit acylcoenzyme A, cholesterol acyltransferase (ACAT) activity, inhibit rat liver microbody ACAT with IC50 of 18 μmol/L, and its action is competitive with oleoyl-COA substrate, Ki value is 5.5 μmol/L. It also inhibits [14C] oleic acid from forming cholesterol esters with IC50 of 0.65 μmol/L. Synonyms: Gypsetine; (-)-Gypsetin; 8a,16a-Dihydroxy-5a,13a-bis(1,1-dimethylallyl)-(1)-benzazolidine-(3''',2''':4'',5'')azolidino-(1'',2'':4',5')(1,4)perhydrodiazin-(1',2':1,5)azolidino-(2,3-b)-(1)-benzazolidine-7,15-dione; Pyrazino(1'', 2'':1, 5;4'', 5'':1', 5')dipyrrolo(2, 3-b:2', 3'-b')diindole-7, 15(5H, 7aH)-dione, 5a, 13a-bis(1, 1-dimethyl-2-propenyl)-5a, 8, 8a, 13, 13a, 15a, 16, 16a-octahydro-8a, 16a-dihydroxy-, (5aalpha, 7aalpha, 8abeta, 13abeta, 15aalpha, 16aalpha)-. CAS No. 155114-38-8. Molecular formula: C32H36N4O4. Mole weight: 540.66. | |
IWP 12 Quick inquiry Where to buy Suppliers range | IWP 12 is a Wnt inhibitor that prevents palmitylation of Wnt proteins by Porcupine (Porcn). It blocks post resection juvenile zebrafish tailfin regeneration and is suitable for in vivo assays. It is a membrane-bound O-acyltransferase (MBOAT) and activates Wnt proteins with IC50 value of 15 nM. It inhibits Wnt/β-catenin and Wnt/planar cell polarity (PCP) signaling pathways. Synonyms: IWP12; IWP 12; IWP-12; N-(6-Methyl-2-benzothiazolyl)-2-[(3,4,6,7-tetrahydro-3,6-dimethyl-4-oxothieno[3,2-d]pyrimidin-2-yl)thio]acetamide. Grades: ≥98% by HPLC. CAS No. 688353-45-9. Molecular formula: C18H18N4O2S3. Mole weight: 418.56. | |
IWP-2 (N-(6-Methyl-2-benzothiazolyl)-2-[(3,4,6,7-tetrahydro-4-oxo-3-phenylthieno[3,2-d]pyrimidin-2-yl)thio]-acetamide) Quick inquiry Where to buy Suppliers range | Cell-permeable. Acts as an inhibitor of Wnt secretion and processing. It blocks Wnt-dependent signaling (IC50 = 27nM) by inhibition of the O-acyltransferase Porcn. Porcn is a member of the membrane-bound O-acyltransferase (MBOAT) family, which adds a palmitoyl group to Wnt proteins that is essential to their signaling ability and is required for Wnt secretion. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 5mg, 25mg. US Biological Life Sciences. | Worldwide |
IWP-2-V2 Quick inquiry Where to buy Suppliers range | IWP-2 is an inhibitor of Wnt production (IC50 = 27 nM) that inhibits porcupine, a membrane-bound acyltransferase that is essential to the pamitoylation of Wnt ligands. IWP-2-V2 is an IWP-2 derivative with less potency. Synonyms: 2-((3-benzyl-4-oxo-3,4,6,7-tetrahydrothieno[3,2-d]pyrimidin-2-yl)thio)-N-(6-methylbenzo[d]thiazol-2-yl)acetamide. Grades: ≥98%. CAS No. 877618-79-6. Molecular formula: C23H20N4O2S3. Mole weight: 480.6. | |
JTP 103237 Quick inquiry Where to buy Suppliers range | JTP 103237 is a potent and selective monoacyglycerol acyltransferase 2 (MGAT2) inhibitor (IC50 = 20-40 nM), exhibiting >7000-fold selectivity for human MOGAT2 over human DGAT2. In a high sucrose very low fat (HSVLF) diet induced fatty liver model, JTP-103237 reduced hepatic triglyceride content and hepatic MGAT activity, suppressed not only triglyceride (TG) and diacylglycerol (DG) synthesis, but also fatty acid (FA) synthesis (de novo lipogenesis). Synonyms: 7-[4,6-Bis(1,1-dimethylethyl)-2-pyrimidinyl]-5,6,7,8-tetrahydro-3-[4-(trifluoromethoxy)phenyl]-1,2,4-triazolo[4,3-a]pyrazine. Grades: ≥98% by HPLC. CAS No. 1883864-16-1. Molecular formula: C24H29F3N6O. Mole weight: 474.52. | |
LCQ-908 Quick inquiry Where to buy Suppliers range | LCQ-908 is a new generation of diacylglycerol acyltransferase 1 (DGAT1) inhibitor as anti-obesity and anti-diabetic agents. It is now in phase II clinical trials. Synonyms: Pradigastat; LCQ-908; LCQ 908; LCQ908. Grades: >98%. CAS No. 956136-95-1. Molecular formula: C25H24F3N3O2. Mole weight: 455.47. | |
LGK974 (LGK-974, WNT-974, LGK 974, NVP-LGK974) Quick inquiry Where to buy Suppliers range | LGK974 is a highly potent inhibitor of Porcupine (PORCN), a Wnt-specific acyltransferase. LGK974 is orally bioavailable and inhibits WNT signaling in vitro and in vivo. It is reported to exhibit anti-tumor properties without increasing cytotoxicity. Group: Biochemicals. Alternative Names: 2-[5-methyl-6-(2-methylpyridin-4-yl)pyridin-3-yl]-N-(5-pyrazin-2-ylpyridin-2-yl)acetamide; LGK-974; WNT-974; LGK 974; NVP-LGK974; 2,3-Dimethyl-N-[5-(2-pyrazinyl)-2-pyridinyl]-[2,4-bipyridine]-5-acetamide; 2-(2,3-Dimethyl-[2,4-bipyridin]-5-yl)-N-(5-(pyrazin-2-yl)pyridin-2-yl)acetamide. Grades: Highly Purified. CAS No. 1243244-14-5. Pack Sizes: 1mg, 5mg, 25mg, 100mg. Molecular Formula: C??H??N?O, Molecular Weight: 396.44. US Biological Life Sciences. | Worldwide |
Lipid Metabolism Compound Library Quick inquiry Where to buy Suppliers range | A unique collection of 496 compounds targeting lipid metabolism, can be used for high-throughput screening (HTS) and high-content screening (HCS). - Covers several important targets, key components in lipid metabolism pathway, such as Acetyl-CoA Carboxylase?Acyltransferase?cholesteryl ester transfer protein (CETP)?FAAH?Fatty Acid Synthase (FASN)?HMG-CoA Reductase (HMGCR), etc. - Detailed compound information with structure, target, and biological activity description. - NMR and HPLC validated to ensure high purity and quality. Uses: Scientific use. Product Category: L2510. Categories: Lipid Metabolism Compounds Libraries. | |
MGAT2-IN-1 Quick inquiry Where to buy Suppliers range | An orally active inhibitor of monoacylglycerol acyltransferase (MGAT2) (IC50= 7.8 for human, and 2.4 nM for mouse MGAT2). Synonyms: N-(4-chloro-2,6-difluorophenyl)-1-[5-[2-methyl-5-(trifluoromethyl)pyrazol-3-yl]pyrimidin-2-yl]-7-(2-oxopyrrolidin-1-yl)-2,3-dihydroindole-5-sulfonamide. CAS No. 1800025-30-2. Molecular formula: C27H21ClF5N7O3S. Mole weight: 654.01. | |
Oleic acid-2,6-diisopropylanilide Quick inquiry Where to buy Suppliers range | Oleic acid-2,6-diisopropylanilide is an inhibitor of acylCoA:cholesterol acyltransferase (ACAT), an intracellular protein involved in cholesterol metabolism. Synonyms: (Z)-N-(2,6-Diisopropylphenyl)-9-octadecenamide. Grades: ≥98%. CAS No. 140112-65-8. Molecular formula: C30H51NO. Mole weight: 441.7. | |
Oleoyl-L-carnitine Quick inquiry Where to buy Suppliers range | Oleoyl-L-carnitine is a metabolite of carnitine. It inhibits lecithin:cholesterol acyltransferase (LCAT) activity in isolated rat. Synonyms: C18:1 Carnitine; L-Carnitine oleoyl ester; L-Oleoylcarnitine; (3R)-3-[(Z)-octadec-9-enoyl]oxy-4-(trimethylazaniumyl)butanoate. Grades: ≥95%. CAS No. 38677-66-6. Molecular formula: C25H47NO4. Mole weight: 425.65. | |
Oleyl anilide Quick inquiry Where to buy Suppliers range | Oleyl analide (OA) is a weak inhibitor of acylCoA:cholesterol acyltransferase (ACAT), an intracellular protein located in the endoplasmic reticulum that forms cholesteryl esters. OA and the related glyceride dioleoyl phenylamino propane 1,2-diol have been linked to a syndrome of eosinophilia, excessive T-cell activation, and elevated interleukin-4 (IL-4), soluble IL-2R, and IL-5. Synonyms: OA; Oleic acid anilide; Cis-9-octadecenanilide; (Z)-N-phenyloctadec-9-enamide. Grades: ≥95%. CAS No. 5429-85-6. Molecular formula: C24H39NO. Mole weight: 357.6. | |
Palmitoyl-L-carnitine chloride Quick inquiry Where to buy Suppliers range | Palmitoyl-L-carnitine is a long-chain acylcarnitine. It inhibits lecithin:cholesterol acyltransferase activity in rat. Synonyms: Hexadecanoyl-L-carnitine; L-Hexadecanoylcarnitine; L-Palmitoylcarnitine; [(2R)-3-carboxy-2-hexadecanoyloxypropyl]-trimethylazanium chloride. Grades: ≥95%. CAS No. 18877-64-0. Molecular formula: C23H46NO4·Cl. Mole weight: 436.07. | |
PD 138142 Quick inquiry Where to buy Suppliers range | PD 138142 is a water soluble Sterol O-acyltransferase inhibitor. Triacylglycerol secretion is decreased in the presence of PD-138142-15. Preclinical development for Hypercholesterolaemia in USA was discontinued. Uses: Hypercholesterolaemia. Synonyms: PD-138142; PD138142; PD 138142; 2,6-diisopropylphenyl (2,6-diisopropylphenoxy)carbonylsulfamate. Grades: 98%. CAS No. 142642-31-7. Molecular formula: C25H35NO5S. Mole weight: 461.62. | |
Penicillide Quick inquiry Where to buy Suppliers range | Penicillide is an acyl-CoA: cholesterol acyltransferase (ACAT) inhibitor produced by Penicillum asperosporum KY1635. The IC50 for inhibiting ACAT was 22.9 μmol/L. Synonyms: Vermixocin A; AS-186a; 11-hydroxy-3-[(1s)-1-hydroxy-3-methylbutyl]-4-methoxy-9-methyl-5h,7h-dibenzo[b,g][1,5]dioxocin-5-one. Grades: ≥95%. CAS No. 55303-92-9. Molecular formula: C21H24O6. Mole weight: 372.41. | |
Penicillide (Vermixocin A, Antibiotic AS 186A, Antibiotic MC 140) Quick inquiry Where to buy Suppliers range | Plant growth inhibitor. Acyl-CoA-cholesterol acyltransferase (ACAT) inhibitor. Anticancer compound. Cytotoxic. Non-peptidic oxytocin receptor antagonist. Calpain inhibitor. Source:Isolated from Penicillium sp. Group: Biochemicals. Alternative Names: Vermixocin A, Antibiotic AS 186A, Antibiotic MC 140. Grades: Highly Purified. CAS No. 55303-92-9. Pack Sizes: 250ug, 1mg. Molecular Formula: C21H24O6, Molecular Weight: 372.4. US Biological Life Sciences. | Worldwide |
PF-04620110 Quick inquiry Where to buy Suppliers range | PF-04620110 is an orally active, selective and potent diglyceride acyltransferase-1 (DGAT1) inhibitor with IC50 of 19 nM. Synonyms: PF-04620110; PF 04620110; PF04620110. PF-4620110; PF 4620110; PF4620110. Grades: >98%. CAS No. 1109276-89-2. Molecular formula: C21H24N4O4. Mole weight: 396.44. | |
PF 06424439 Quick inquiry Where to buy Suppliers range | PF 06424439 is a potent, selective and orally bioavailable Diacylglycerol Acyltransferase 2 ( DGAT2) inhibitor with DGAT2 IC50 ± SEM (nM) (human/rat/dog) 14 ± 1/38 ± 4/16 ± 1, which exhibits no significant activity at MGAT1-3 or DGAT1. It reduces triglyderide synthesis in human hepatocytes in vitro, and reduces plasma triglyceride and cholesterol levels in a rat dyslipidemia model. Synonyms: [(3R)-1-[2-[1-(4-Chloro-1H-pyrazol-1-yl)cyclopropyl]-3H-imidazo[4,5-b]pyridin-5-yl]-3-piperidinyl]-1-pyrrolidinylmethanone methanesulfonate; PF-06424439; PF06424439; PF 06424439; PF-6424439; PF-6424439; PF 6424439. Grades: ≥98% by HPLC. CAS No. 1469284-79-4. Molecular formula: C22H26ClN7O.CH4O3S. Mole weight: 536.05. | |
Purpactin A Quick inquiry Where to buy Suppliers range | Purpactin A is a cholesterol acyltransferase (ACAT) inhibitor produced by Pen. purpurogenum FO-6. Synonyms: 1'-O-acetylpenicillide; Vermixocin B. Molecular formula: C23H26O7. Mole weight: 414.45. | |
Purpactin B Quick inquiry Where to buy Suppliers range | Purpactin B is a cholesterol acyltransferase (ACAT) inhibitor produced by Pen. purpurogenum FO-6. Synonyms: 1-[2'-(hydroxymethyl)-4-methoxy-4'-methyl-3,6'-dioxo-3h-spiro[1-benzofuran-2,1'-cyclohexa[2,4]dien]-5-yl]-3-methylbutyl acetate. CAS No. 133806-60-7. Molecular formula: C23H26O7. Mole weight: 414.45. | |
Purpactin C Quick inquiry Where to buy Suppliers range | Purpactin C is a cholesterol acyltransferase (ACAT) inhibitor produced by Pen. purpurogenum FO-6. CAS No. 133806-61-8. Molecular formula: C23H24O7. Mole weight: 412.43. | |
Putative protein product of HMFN1045 (253-264) Quick inquiry Where to buy Suppliers range | Diacylglycerol O-acyltransferase 2. Uses: Tumor Antigen Derived Peptides. CAS No. Product ID: ta-139. | |
Pyripyropene A Quick inquiry Where to buy Suppliers range | Pyripyropene A is a powerful acyl-CoA: cholesterol acyltransferase 2 (ACAT2) inhibitor produced by the fungus Aspergillus fumigatus FO 1289. It inhibits acyl-CoA: cholesterol acyltransferase with an IC50 of 58 nmol/L. Synonyms: (3S,4R,4aR,6S,6aS,12R,12aS,12bS)-4-(acetoxymethyl)-12-hydroxy-4,6a,12b-trimethyl-11-oxo-9-(pyridin-3-yl)-1,3,4,4a,5,6,6a,12,12a,12b-decahydro-2H,11H-benzo[f]pyrano[4,3-b]chromene-3,6-diyl diacetate; (3S,4R,4aR,6S,6aS,12R,12aS,12bS)-4-(Acetoxymethyl)-12-hydroxy-4,6a,12b-trimethyl-11-oxo-9-(pyridin-3-yl)-1,2,3,4,4a,5,6,6a,11,12,12a,12b-dodecahydrobenzo[f]pyrano[4,3-b]chromene-3,6-diyl diacetate. Grades: ≥95%. CAS No. 147444-03-9. Molecular formula: C31H37NO10. Mole weight: 583.62. | |
Pyripyropene B Quick inquiry Where to buy Suppliers range | Pyripyropene B is a powerful acyl-CoA: cholesterol acyltransferase 2 (ACAT2) inhibitor produced by the fungus Aspergillus fumigatus FO 1289. It inhibits acyl-CoA: cholesterol acyltransferase with an IC50 of 117 nmol/L. Synonyms: 2H,11H-Naphtho[2,1-b]pyrano[3,4-e]pyran-11-one,3,6-bis(acetyloxy)-1,3,4,4a,5,6,6a,12,12a,12b-decahydro-12-hydroxy-4,6a,12b-trimethyl-4-[(1-oxopropoxy)methyl]-9-(3-pyridinyl)-,(3S,4R,4aR,6S,6aS,12R,12aS,12bS)-. CAS No. 151519-44-7. Molecular formula: C32H39NO10. Mole weight: 597.65. | |
RUSKI-201 dihydrochloride Quick inquiry Where to buy Suppliers range | RUSKI-201 dihydrochloride is a sonic hedgehog acyltransferase (HHAT) inhibitor (IC50 = 0.20 μM) devoid of off-target cytotoxicity, and quantitative whole-proteome palmitoylation profiling with a bioorthogonal alkyne-palmitate reporter. Synonyms: RUSKI-201 dihydrochloride; RUSKI 201 dihydrochloride; RUSKI201 dihydrochloride; 2-(2-methylbutylamino)-1-(4-(6-methylpyridin-2-yl)-6,7-dihydrothieno[3,2-c]pyridin-5(4H)-yl)ethanone dihydrochloride. Grades: 98%. Molecular formula: C20H27N3OS.2HCl. Mole weight: 430.43. | |
RU-SKI 43 Quick inquiry Where to buy Suppliers range | RU-SKI 43 is a small molecule inhibitor of Hhat(Hedgehog acyltransferase), the enzyme responsible for the attachment of palmitate onto Shh. Synonyms: RU-SKI 43; RU SKI 43; RUSKI43. Grades: >98%. CAS No. 1043797-53-0. Molecular formula: C22H30N2O2S. Mole weight: 386.55. | |
RU-SKI 43 hydrochloride Quick inquiry Where to buy Suppliers range | RU-SKI 43 is a potent and selective inhibitor of Hedgehog acyltransferase (HHAT). It blocks palmitoylation of Shh without affecting palmitoylation of H-Ras or Fyn, myristoylation of c-Src, or acylation of Wnt3a. Synonyms: 2-(2-methylbutylamino)-1-[4-[(3-methylphenoxy)methyl]-6,7-dihydro-4H-thieno[3,2-c]pyridin-5-yl]ethanone hydrochloride. Grades: ≥98%. CAS No. 1782573-67-4. Molecular formula: C22H30N2O2S·HCl. Mole weight: 423. | |
Stearoyl-L-carnitine chloride Quick inquiry Where to buy Suppliers range | Stearoyl-L-carnitine is a naturally-occurring long-chain acylcarnitine. It inhibits lecithin:cholesterol acyltransferase activity in rat plasma when used at a concentration of 500 μM/ml of plasma. It also inhibits PKC. Synonyms: C18 Carnitine chloride; Octadecanoyl-L-carnitine chloride; R-Stearoyl carnitine chloride. Grades: ≥95%. CAS No. 32350-57-5. Molecular formula: C25H50NO4·Cl. Mole weight: 464.12. | |
Sterigmatocystin Quick inquiry Where to buy Suppliers range | Sterigmatocystin is a mycotoxin produced by several species of aspergillus. It is structurally related to the aflatoxins. It is mutagenic, teratogenic and carcinogenic and is less widespread and potent than Aflatoxin. It inhibits acyl-CoA. It is a cholesterol acyltransferase (ACAT) with selectivity for the ACAT2 isoenzyme. Synonyms: (3aR,12cS)-3a,12c-Dihydro-8-hydroxy-6-methoxy-7H-furo[3',2':4,5]furo[2,3-c]xanthen-7-one; (3aR-cis)-3a,12c-Dihydro-8-hydroxy-6-methoxy-7H-furo[3',2':4,5]furo[2,3-c]xanthen-7-one; NSC 201423; NSC 204985; Sterigmatocystine. Grades: >95% by HPLC. CAS No. 10048-13-2. Molecular formula: C18H12O6. Mole weight: 324.28. | |
Sterigmatocystin (NSC 201423, NSC 204985) Quick inquiry Where to buy Suppliers range | Intermediate of the biosynthetic pathway to aflatoxin B1. Mycotoxin. DNA synthesis inhibitor. Anticancer compound. Cytotoxic, carcinogenic and mutagenic. Acyl-CoA:cholesterol acyltransferase 2 (ACAT2) inhibitor. Shown to induce apoptosis in human peripheral lymphocytes and necrosis in rat liver. Induces sister chromatid exchanges in murine bone marrow cells. Group: Biochemicals. Grades: Highly Purified. CAS No. 10048-13-2. Pack Sizes: 1mg, 5mg. US Biological Life Sciences. | Worldwide |
T863 Quick inquiry Where to buy Suppliers range | T-863 is an orally active, selective and potent DGAT1 (Acyl-CoA:diacylglycerol acyltransferase 1) inhibitor that interacts with the acyl-CoA binding site of DGAT1, and inhibits triacylglycerol synthesis in cells. It causes weight loss, reduction in serum and liver triglycerides, and improved insulin sensitivity in obese mice. Synonyms: DGAT-1 inhibitor; DGAT 1 inhibitor; T863; T-863; T 863. Grades: >98%. CAS No. 701232-20-4. Molecular formula: C22H26N4O3. Mole weight: 394.47. | |
Terpendole A Quick inquiry Where to buy Suppliers range | Terpendole A is an acyl-CoA: cholesterol acyltransferase (ACAT) inhibitor produced by Albophoma yamenashiensis. The IC50 that inhibits ACAT in macrophages is 0.29 μmol/L, and the CD50 that causes 50% cell damage is greater than 23.4 μmol/L. Molecular formula: C32H41NO6. Mole weight: 535.67. | |
Terpendole C Quick inquiry Where to buy Suppliers range | Isolated from Albophoma yamanashiensis. An acyl-CoA:cholesterol acyltransferase (ACAT) isozymes ACAT1 and ACAT2 inhibitor. Also acts as a tremorgen and cholesteryl ester (CE) synthesis inhibitor. Group: Biochemicals. Grades: Highly Purified. CAS No. 156967-65-6. Pack Sizes: 250ug, 1mg. US Biological Life Sciences. | Worldwide |