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| Product | Description | |
|---|---|---|
| Adaphostin | ?98% (HPLC). Group: Fluorescence/luminescence spectroscopy. |  |
| Adaphostin | Adaphostin is a p210bcr/abl tyrosine kinase inhibitor with IC50 value of 14 μM. It shows anti-proliferative activity in human prostate cancer cell line PC-3, leukemia models and other cancer cell lines. It is a potent inducer of myeloid cell death. It could induce a degradation of WT and mutated Bcr/Abl and induce apoptosis in tumor cells. It shows selectivity for chronic myelogenous leukemia (CML) myeloid progenitors in vitro. It is used as a novel antitumor agent. Synonyms: 4-[[(2,5-Dihydroxyphenyl)methyl]amino]benzoic acid tricyclo[3.3.1.13,7]dec-1-yl ester; AG 957 Adamantyl Ester; NSC 680410; AG957 Adamantyl Ester; NSC680410; AG-957 Adamantyl Ester; NSC-680410. Grades: ≥98% by HPLC. CAS No. 241127-58-2. Molecular formula: C24H27NO4. Mole weight: 393.48. |  |
| Adaphostin | Adaphostin (NSC 680410), the adamantyl ester of AG957, is a potent p210 bcr/abl inhibitor ( IC 50 =14 μM). Adaphostin induces apoptosis in T-lymphoblastic human leukemia cell lines (IC 50 ranging from 17 to 216 nM). Adaphostin has significant and selective activity against chronic and acute myeloid leukemia cells. Adaphostin increased the level of reactive oxygen species (ROS) within CLL B cells [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: NSC 680410. CAS No. 241127-58-2. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-103275. |  |
| Adaphostin | Novel antitumor agent that induces apoptosis in tumor cells through inhibition of the tyrosine kinase BCR/ABL. Group: Biochemicals. Alternative Names: 4-[[ (2, 5-Dihydroxyphenyl) methyl]amino]benzoic Acid Tricyclo[3.3.1.13, 7]dec-1-yl Ester; NSC 680410. Grades: Highly Purified. CAS No. 241127-58-2. Pack Sizes: 25mg. US Biological Life Sciences. |  Worldwide |
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