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Adenylyl-(3'-5')-adenosine is a pivotal biomolecule with extensive applications in studying signaling pathways, particularly cAMP-dependent processes. It aids in understanding cyclic nucleotide metabolism and exploring associated afflictions encompassing cancer, diabetes and cardiovascular disorders. Synonyms: ApA RNA Dinucleotide (5'-3'); AmpA; 5'-Adenylic acid, 3'-ester with adenosine; 3',5'-ApA; D-Adenylyl-(3'-5')-D-adenosine; Adenylyl-(5'→3')-adenosine; Adenylyladenosine; Diadenosine 3',5'-monophosphate; NSC 91555; ApA. Grade: ≥98%. CAS No. 2391-46-0. Molecular formula: C20H25N10O10P. Mole weight: 596.45.
Adenylyl-(3'-5')-adenosine monoammonia salt
Adenylyl-(3'-5')-adenosine monoammonia salt is a vital compound utilized in biomedical research. It is commonly employed for studying intracellular signaling pathways and second messengers, including cAMP (cyclic adenosine monophosphate). This product plays a crucial role in investigating the activation and regulation of various enzymes, receptors, and ion channels involved in multiple diseases, such as cancer, cardiovascular disorders, and neurological conditions. Its high purity and quality ensure accurate and reliable experimental results. Synonyms: ADENYLYL(3'-5')ADENOSINE; APA. Grade: 95%. CAS No. 102029-96-9. Molecular formula: C20H25N10O10P.NH3. Mole weight: 613.48.
Adenylyl-3'-5'-adenosine ammonium salt
Adenylyl-3'-5'-adenosine ammonium salt, a paramount substance utilized in the realm of biomedicine, assumes a pivotal function in the amelioration of diverse maladies encompassing cancer, cardiovascular afflictions, and metabolic irregularities. By adeptly modulating intracellular signaling cascades, this groundbreaking agent efficaciously facilitates the inception of precisely tailored remedies targeted at combating these ailments. Synonyms: Adenosine, adenylyl-(3'.5')-, ammonium salt; 21027-46-3; EINECS 244-153-3; azanium; [(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methyl [(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-4-hydroxy-2-(hydroxymethyl)oxolan-3-yl] phosphate. CAS No. 21027-46-3. Molecular formula: C20H25N10O10P. Mole weight: 596.45.
Adenylyl-3'-5'-cytidine
Adenylyl-3'-5'-cytidine is a highly effective and specialized adenylyl cyclase activator, holding applications in biomedical research for investigating the cyclic adenosine monophosphate (cAMP) signaling pathways. Uses: Enzyme inhibitors. Synonyms: CmpA; Adenylyl-3'-5'-D-cytidine; 5'-Adenylic acid, 3'-ester with cytidine; Cytidylyl-(3'→5')-adenosine; Cytidine, adenylyl-(5'→3')-; Cytidylyl-3',5'-adenosine; NSC 91552; Cytidylyl adenosine; Cytidylyl-3',5'-adenosine phosphate; (3'-5')CpA; Cytidylyl-(3'-5')-adenosine; CpA; Cytidylyl(3',5')adenosine. Grade: 98%. CAS No. 2382-66-3. Molecular formula: C19H25N8O11P. Mole weight: 572.42.
Guanylyl-(3',5')-adenosine
Guanylyl-(3',5')-adenosine, a cyclic nucleotide second messenger, intricately orchestrates various cellular signaling pathways, rendering it crucial in regulating a myriad of physiological functions, ranging from neurotransmitter release to smooth muscle contraction. A versatile molecule of interest, this compound boasts promising potential in the therapeutic arena, especially for treating cardiovascular diseases, such as hypertension and heart failure, thanks to its adeptness in modulating platelet activation and gene expression. Synonyms: GmpA; Guanine ribonucleotidyl-(3'-5')-adenosine; Adenylyl-(5',3')-guanosine; GpA RNA Dinucleotide (5'-3'); GpA; Guanylyladenosine. Grade: ≥95% by AX-HPLC. CAS No. 6554-00-3. Molecular formula: C20H25N10O11P. Mole weight: 612.45.
2'2'-cGAMP
c[A(2',5')pG(2',5')p] is a cyclic dinucleotide analogue of c[G(2',5')pA(3',5')p], the metazoan second messenger and STING activator. It can bind the signalling protein STING and induces type I interferons. Synonyms: cGAMP(2'-5'); 2'-Guanylic acid, adenylyl-(2'→5')-, cyclic nucleotide; c[G(2',5')pA(2',5')p]; 2',5'-cyclic GMP-AMP; Cyclic (adenosine-(2'→5')-monophosphate-guanosine-(2'→5')-monophosphate). Grade: ≥98% by HPLC. CAS No. 1465774-27-9. Molecular formula: C20H24N10O13P2. Mole weight: 674.41.
3'-O-(5'-Cytidylyl)adenosine
3'-O-(5'-Cytidylyl)adenosine is a nucleoside consisting of a cytidine molecule linked to an adenosine molecule via a phosphodiester bond at the 3'- and 5'-position, respectively. It is used in the biomedical industry as a tool to investigate RNA editing, since it can be incorporated into RNA molecules during transcription and can serve as a marker for the editing process. Additionally, it has been shown to have potential therapeutic properties for the treatment of neurological and psychiatric disorders. Synonyms: adenylyl-(3'-5')-cytidine; ApC RNA Dinucleotide (5'-3'). Molecular formula: C19H25N8O11P. Mole weight: 572.40.
Adenosine 3'-Phosphate 5'-Phosphosulfate Tetralithium Salt
Adenosine 3'-Phosphate 5'-Phosphosulfate Tetralithium Salt is a pivotal compound recompound, playing an indispensable role in elucidating the intricate intricacies of adenosine nucleotide metabolism and signaling pathways. It functions as a substrate for the esteemed enzyme APS kinase, thereby exerting its influence on the research and development of both phosphoadenosine phosphosulfate (PAPS) and ATP. Synonyms: Adenosine 3'-phosphate 5'-phosphosulfate lithium salt; Phosphoadenosine phosphosulfate tetralithium salt; 3'-Phosphoadenylyl sulfate tetralithium salt; PAPS tetralithium salt; 3'-Phosphoadenosine 5'-phosphosulfate tetralithium salt; 5'-Adenylyl sulfate 3'-phosphate tetralithium salt; Adenosine 3'-phosphate 5'-sulfatophosphate tetralithium salt; Adenosine 5'-phosphosulfate 3'-phosphate tetralithium salt. Grade: ≥80%. CAS No. 102029-54-9. Molecular formula: C10H11Li4N5O13P2S. Mole weight: 531.00.
Adenylyl-(3'-5')-cytidine
Adenylyl-(3'-5')-cytidine is a nucleotide derivative involved in RNA metabolism and signaling pathways. It plays a role in various biological processes, including RNA modification and cellular signaling. Adenylyl-(3'-5')-cytidine is used in biochemical and molecular biology research to study RNA-related processes, including RNA capping mechanisms, mRNA processing, and interactions with enzymes involved in RNA metabolism. This compound serves as a model substrate to investigate RNA modification dynamics and its impact on RNA stability and function. Synonyms: Cytidylyl(5'->3')adenosine; AmpC; 3'-Adenylic acid, 5'-ester with cytidine; Adenosine, cytidylyl-(5'→3')-; Adenylyl-(3'→5')-cytidine; Adenylylcytosine; ApC; NSC 131652; NSC 91551. Grade: 95%. CAS No. 4833-63-0. Molecular formula: C19H25N8O11P. Mole weight: 572.42.
Adenylyl-(3'-5')-guanosine
ADENYLYL-(3'-5')-GUANOSINE, a fundamental molecule in cellular signaling pathways, is an indispensable regulator of intracellular communication. It assumes a pivotal position in the control of diverse biological phenomena encompassing DNA synthesis and repair, cell growth, as well as immune responses. In the realm of biomedicine, ADENYLYL-(3'-5')-GUANOSINE finds utility in the investigation of second messenger signaling, cyclic nucleotide regulation, and the therapeutic management of afflictions including cancer, cardiovascular disorders, and neurodegenerative conditions. Synonyms: Guanosine, adenylyl-(3'→5')-; 3'-Adenylic acid, 5'-ester with guanosine; Adenylyl-(3'→5')-guanosine; A-G; Adenosine, guanylyl-(5'→3')-; NSC 91554; ((2R,3S,4R,5R)-5-(2-amino-6-oxo-1,6-dihydro-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl ((2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-4-hydroxy-2-(hydroxymethyl)tetrahydrofuran-3-yl) hydrogen phosphate; 3'-O-(5'-Guanylyl)adenosine. Grade: ≥95%. CAS No. 3352-23-6. Molecular formula: C20H25N10O11P. Mole weight: 612.45.
Adenylyl-(3'-5')-guanosine monoammonium salt
Adenylyl-(3'-5')-guanosine monoammonium salt is an indispensable biomedical instrument used in scientific investigations, playing an imperative role in unraveling intricate cellular signaling pathways and elucidating the enigmatic realm of nucleotide metabolism. This remarkable compound acting as a precursor for the formation of cyclic adenosine monophosphate (cAMP), a critical molecule that orchestrates multifarious biological processes, encompassing compound responses, enzyme activation and hormonal regulation. Synonyms: Guanosine, adenylyl-(3'→5')-, monoammonium salt; ((2R,3S,4R,5R)-5-(2-amino-6-oxo-1,6-dihydro-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl ((2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-4-hydroxy-2-(hydroxymethyl)tetrahydrofuran-3-yl) hydrogen phosphate, monoammonium salt. CAS No. 102029-53-8. Molecular formula: C20H25N10O11P.H3N. Mole weight: 629.48.
adenylyl-sulfate kinase
The human phosphoadenosine-phosphosulfate synthase (PAPSS) system is a bifunctional enzyme (fusion product of two catalytic activities). In a first step, sulfate adenylyltransferase catalyses the formation of adenosine 5'-phosphosulfate (APS) from ATP and inorganic sulfate. The second step is catalysed by the adenylylsulfate kinase portion of 3'-phosphoadenosine 5'-phosphosulfate (PAPS) synthase, which involves the formation of PAPS from enzyme-bound APS and ATP. In contrast, in bacteria, yeast, fungi and plants, the formation of PAPS is carried out by two individual polypeptides, sulfate adenylyltransferase (EC 2.7.7.4) and adenylyl-sulfate kinase (EC 2.7.1.25). Group: Enzymes. Synonyms: adenylylsulfate kinase (phosphorylating); 5'-phosphoadenosine sulfate kinase; adenosine 5'-phosphosulfate kinase; adenosine phosphosulfate kinase; adenosine phosphosulfokinase; . Enzyme Commission Number: EC 2.7.1.25. CAS No. 9012-38-8. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-3055; adenylyl-sulfate kinase; EC 2.7.1.25; 9012-38-8; adenylylsulfate kinase (phosphorylating); 5'-phosphoadenosine sulfate kinase; adenosine 5'-phosphosulfate kinase; adenosine phosphosulfate kinase; adenosine phosphosulfokinase; adenosine-5'-phosphosulfate-3'-phosphokinase; APS kinase. Cat No: EXWM-3055.
adenylyl-sulfate reductase (glutathione)
This enzyme differs from EC 1.8.99.2, adenylyl-sulfate reductase, in using glutathione as the reductant. Glutathione can be replaced by γ-glutamylcysteine or dithiothreitol, but not by thioredoxin, glutaredoxin or mercaptoethanol. The enzyme from the mouseear cress, Arabidopsis thaliana, contains a glutaredoxin-like domain. The enzyme is also found in other photosynthetic eukaryotes, e.g., the Madagascar periwinkle, Catharanthus roseus and the hollow green seaweed, Enteromorpha intestinalis. Group: Enzymes. Synonyms: 5'-adenylylsulfate reductase (also used for EC 1.8.99.2); AMP,sulfite:oxidized-glutathione oxidoreductase (adenosine-5'-phosphosulfate-forming); plant-type 5'-adenylylsulfate reductase. Enzyme Commission Number: EC 1.8.4.9. CAS No. 355840-27-6. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-1675; adenylyl-sulfate reductase (glutathione); EC 1.8.4.9; 355840-27-6; 5'-adenylylsulfate reductase (also used for EC 1.8.99.2); AMP,sulfite:oxidized-glutathione oxidoreductase (adenosine-5'-phosphosulfate-forming); plant-type 5'-adenylylsulfate reductase. Cat No: EXWM-1675.
ApCp
ApCp, an avant-garde and unprecedented compound, used for studying an array of ailments, encompassing malignant neoplasms and immune-mediated disorders. Uses: Enzyme inhibitors. Synonyms: Adenosine, 5'-[hydrogen P-(phosphonomethyl)phosphonate]; Adenosine, 5'-(trihydrogen methylenediphosphonate); Adenosine, 5'-[hydrogen (phosphonomethyl)phosphonate]; Adenosine, 5'-methylenediphosphonate; α,β-Methylene adenosine 5'-diphosphate; α,β-Methylene-ADP; α,β-Methylene adenosine diphosphate; Adenosine α,β-methylenediphosphate; α,β-Methylene-5'-ADP; Adenosine 5'-(α,β-methylene)diphosphate; MethADP; AMPCP; 5'-Adenylyl methylenephosphonate. Grade: ≥ 95% by HPLC. CAS No. 3768-14-7. Molecular formula: C11H17N5O9P2. Mole weight: 425.23.
ATP Sulfurylase from S. cerevisiae, Recombinant
In enzymology, a sulfate adenylyltransferase (EC 2.7.7.4) is an enzyme that catalyzes the chemical reaction:ATP + sulfate<-> diphosphate + adenylyl sulfate. Thus, the two substRates of this enzyme are ATP and sulfate, whereas its two products are diphosphate and adenylyl sulfate. This enzyme belongs to the family of transferases, specifically those transferring phosphorus-containing nucleotide groups (nucleotidyltransferases). This enzyme participates in 3 metabolic pathways:purine metabolism, selenoamino acid metabolism, and sulfur metabolism. Adenosine 5-triphosphate sulfurylase yeast recombinant produced in e. coli is a non-glycosylated, polypeptide chain containin...formed from aps and ppi. adenosine 5-triphosphate sulfurylase is purified by proprietary chromatographic techniques. Group: Enzymes. Synonyms: ATP-sulfurylase; adenosine-5'-triphosphate sulfurylase; adenosinetriphosphate sulfurylase; adenylylsulfate pyrophosphorylase; ATP sulfurylase; sulfurylase; EC 2.7.7.4; 9012-39-9; Sulfate adenylate transferase. CAS No. 9012-39-9. ATP-sulfurylase. Storage: at -20°C. Source: E. coli. Species: S. cerevisiae. ATP-sulfurylase; adenosine-5'-triphosphate sulfurylase; adenosinetriphosphate sulfurylase; adenylylsulfate pyrophosphorylase; ATP sulfurylase; sulfurylase; EC 2.7.7.4; 9012-39-9; Sulfate adenylate transferase. Cat No: NATE-1280.
c-(ApIp)
c-(ApIp) is a STING (stimulator of interferon genes)-activating synthetic cyclic dinucleotide (CDN). Synonyms: 3'-Inosinic acid, adenylyl-(3'→5')-, cyclic nucleotide; Cyclic (adenosine monophosphate-inosine monophosphate); cAIMP; CL592; 9-((2R,3R,3aS,7aR,9R,10R,10aS,14aR)-9-(6-amino-9H-purin-9-yl)-3,5,10,12-tetrahydroxy-5,12-dioxidooctahydro-2H,7H-difuro[3,2-d:3',2'-j][1,3,7,9]tetraoxa[2,8]diphosphacyclododecin-2-yl)-1,9-dihydro-6H-purin-6-one; 1-(6-Amino-9H-purine-9-yl)-1'-(6-hydroxy-9H-purine-9-yl)[3-O,5'-O-(hydroxyphosphinylidene)-5-O,3'-O-(hydroxyphosphinylidene)bis(1-deoxy-beta-D-ribofuranose)]; 3',3'-cAIMP; 3',3'-c(ApIp). Grade: ≥ 95% by HPLC. CAS No. 1507367-51-2. Molecular formula: C20H23N9O13P2. Mole weight: 659.40.
In enzymology, a sulfate adenylyltransferase (EC 2.7.7.4) is an enzyme that catalyzes the chemical reaction:ATP + sulfate<-> diphosphate + adenylyl sulfate. Thus, the two substRates of this enzyme are ATP and sulfate, whereas its two products are diphosphate and adenylyl sulfate. This enzyme belongs to the family of transferases, specifically those transferring phosphorus-containing nucleotide groups (nucleotidyltransferases). This enzyme participates in 3 metabolic pathways:purine metabolism, selenoamino acid metabolism, and sulfur metabolism. Applications: Adenosine-5?-triphosphate sulfurylase (atp sulfurylase) may be used to study sulfur metabolism and h...s. Synonyms: ATP-sulfurylase; adenosine-5'-triphosphate sulfurylase; adenosinetriphosphate sulfurylase; adenylylsulfate pyrophosphorylase; ATP sulfurylase; sulfurylase; EC 2.7.7.4; 9012-39-9; Sulfate adenylate transferase. Enzyme Commission Number: EC 2.7.7.4. CAS No. 9012-39-9. ATP-sulfurylase. Activity: > 1.0 units/mg protein. Storage: -20°C. Form: lyophilized powder. Contains Citrate buffer salts. Source: Saccharomyces cerevisiae. ATP-sulfurylase; adenosine-5'-triphosphate sulfurylase; adenosinetriphosphate sulfurylase; adenylylsulfate pyrophosphorylase; ATP sulfurylase; sulfurylase; EC 2.7.7.4; 9012-39-9; Sulfate adenylate transferase. Cat No: NATE-0090.
phosphoadenylyl-sulfate reductase (thioredoxin)
Specific for PAPS. The enzyme from Escherichia coli will use thioredoxins from other species. Group: Enzymes. Synonyms: PAPS reductase, thioredoxin-dependent; PAPS reductase; thioredoxin:adenosine 3'-phosphate 5'-phosphosulfate reductase; 3'-phosphoadenylylsulfate reductase; thioredoxin:3'-phospho-adenylylsulfate reductase; phosphoadenosine-phosphosulfate reductase; adenosine 3',5'-bisphosphate,sulfite:oxidized-thioredoxin oxidoreductase (3'-phosphoadenosine-5'-phosphosulfate-forming). Enzyme Commission Number: EC 1.8.4.8. CAS No. 9068-63-7. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-1674; phosphoadenylyl-sulfate reductase (thioredoxin); EC 1.8.4.8; 9068-63-7; PAPS reductase, thioredoxin-dependent; PAPS reductase; thioredoxin:adenosine 3'-phosphate 5'-phosphosulfate reductase; 3'-phosphoadenylylsulfate reductase; thioredoxin:3'-phospho-adenylylsulfate reductase; phosphoadenosine-phosphosulfate reductase; adenosine 3',5'-bisphosphate,sulfite:oxidized-thioredoxin oxidoreductase (3'-phosphoadenosine-5'-phosphosulfate-forming). Cat No: EXWM-1674.
sulfate adenylyltransferase
The human phosphoadenosine-phosphosulfate synthase (PAPS) system is a bifunctional enzyme (fusion product of two catalytic activities). In a first step, sulfate adenylyltransferase catalyses the formation of adenosine 5'-phosphosulfate (APS) from ATP and inorganic sulfate. The second step is catalysed by the adenylylsulfate kinase portion of 3'-phosphoadenosine 5'-phosphosulfate (PAPS) synthase, which involves the formation of PAPS from enzyme-bound APS and ATP. In contrast, in bacteria, yeast, fungi and plants, the formation of PAPS is carried out by two individual polypeptides, sulfate adenylyltransferase (EC 2.7.7.4) and adenylyl-sulfate kinase (EC 2.7.1.25). Group: Enzymes. Synonyms: ATP-sulfurylase; adenosine-5'-triphosphate sulfurylase; adenosinetriphosphate sulfurylase; adenylylsulfate pyrophosphorylase; ATP sulfurylase; ATP-sulfurylase; sulfurylase. Enzyme Commission Number: EC 2.7.7.4. CAS No. 9012-39-9. ATP-sulfurylase. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-3251; sulfate adenylyltransferase; EC 2.7.7.4; 9012-39-9; ATP-sulfurylase; adenosine-5'-triphosphate sulfurylase; adenosinetriphosphate sulfurylase; adenylylsulfate pyrophosphorylase; ATP sulfurylase; ATP-sulfurylase; sulfurylase. Cat No: EXWM-3251.
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