Adiporon Suppliers USA

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Product
AdipoRon AdipoRon is a novel small-molecule AdipoR agonist, binding to both AdipoR1(Kd=1.8 μM) and AdipoR2(Kd=3.1 μM). Synonyms: AdipoRon; 924416-43-3; 2-(4-benzoylphenoxy)-N-(1-benzylpiperidin-4-yl)acetamide; SC-396658; ND7UVH6GKJ. Grades: >98%. CAS No. 924416-43-3. Molecular formula: C27H28N2O3. Mole weight: 428.52. BOC Sciences
AdipoRon (2-(4-Benzoylphenoxy)-N-[1-(phenylmethyl)-4-piperidinyl]acetamide) Orally-active adiponectin receptor (AdipoR) agonist. Binds to AdipoR1 and AdipoR2 at low um concentration. Activates 5'-adenosine monophosphate-activated protein kinase (AMPK) in cultured mammalian cells. Activates peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC1alpha) which boosts mitochondrial proliferation and energy metabolism. Improves diabetes, glucose and lipid metabolism and insulin sensitivity in cultured cells and in mice by AdipoR-dependent mechanisms. Rescued the shortened lifespan of db/db mice (AdipoRs KO) on high-fat diet. Reduces expression levels of genes encoding inflammatory cytokines such as TNF-alpha, IL-6 and CCL-2 in WAT of WT mice but not db/db mice. Group: Biochemicals. Grades: Highly Purified. CAS No. 924416-43-3. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. USBiological 4
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AdipoRon hydrochloride AdipoRon hydrochloride is the hydrochloride salt and water-soluble derivative of AdipoRon, which is a potent and selective agonist of adiponectin receptors AdipoR1 and AdipoR2 with Kd values of 1.8 and 3.1 μM respectively. It activates PPAR-α and AMPK pathways in the liver and muscle. It ameliorates dyslipidemia, insulin resistance and glucose intolerance in db/db mice. It is a promising treatment for obesity-related diseases such as type 2 diabetes. It is orally active antidiabetic agent. Synonyms: 2-(4-Benzyoylphenoxy)-N-[1-(phenylmethyl)-4-piperidinyl]acetamide hydrochloride. Grades: ≥98% by HPLC. CAS No. 1781835-20-8. Molecular formula: C27H29N2O3Cl. Mole weight: 464.98. BOC Sciences 2
AdipoRon hydrochloride AdipoRon hydrochloride. Group: Biochemicals. Grades: Purified. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. USBiological 5
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Compound 112254 (4- (tert-Butyl) -N- (3- (4- (4-methoxybenzyl) piperazin-1-yl) -3-oxopropyl) benzamide) Adiponectin receptor (AdipoR) agonist. Binds to AdipoR1 and AdipoR2 less potent than AdipoRon. Activates 5'-adenosine monophosphate-activated protein kinase (AMPK) in cultured mammalian cells. Improves diabetes, glucose and lipid metabolism and insulin sensitivity in cultured cells and in mice by AdipoR-dependent mechanisms. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. USBiological 4
Worldwide