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| Product | Description | |
|---|---|---|
| Afobazole | Fabomotizole (brand name Afobazole) is an anxiolytic drug launched in Russia in the early 2000s. It produces anxiolytic and neuroprotective effects without any sedative or muscle relaxant actions. Its mechanism of action remains poorly defined however, with GABAergic, NGF- and BDNF-release-promoting, MT1 receptor agonism, MT3 receptor antagonism, and sigma agonism suggested as potential mechanisms. Fabomotizole was shown to inhibit MAO-A reversibly and there might be also some involvement with serotonin receptors. Clinical trials have shown fabomotizole to be well tolerated and reasonably effective for the treatment of anxiety. Experiments of mice have showed antimutagenic and antiteratogenic properties. Synonyms: CM346; Afobazol; Fabomotizole; CM 346; CM-346. Grades: >98%. CAS No. 173352-21-1. Molecular formula: C15H21N3O2S. Mole weight: 307.41. |  |
| Afobazole hydrochloride | Fabomotizole (brand name Afobazole) is an anxiolytic drug launched in Russia in the early 2000s. It produces anxiolytic and neuroprotective effects without any sedative or muscle relaxant actions. Its mechanism of action remains poorly defined however, with GABAergic, NGF- and BDNF-release-promoting, MT1 receptor agonism, MT3 receptor antagonism, and sigma agonism suggested as potential mechanisms. Fabomotizole was shown to inhibit MAO-A reversibly and there might be also some involvement with serotonin receptors. Clinical trials have shown fabomotizole to be well tolerated and reasonably effective for the treatment of anxiety. Experiments of mice have showed antimutagenic and antiteratogenic properties. Synonyms: CM346 hydrochloride; Afobazol hydrochloride; Fabomotizole hydrochloride; CM 346 hydrochloride; CM-346 hydrochloride. Grades: >98%. CAS No. 173352-39-1. Molecular formula: C15H22ClN3O2S. Mole weight: 343.87. | |
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