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| Product | Description | |
|---|---|---|
| AGI-5198 | ?98% (HPLC). Group: Fluorescence/luminescence spectroscopy. |  |
| AGI-5198 | AGI-5198, also know as IDH-C35, is the a very potent and selective mutant IDH1 inhibitor that was shown to potential anticancer activity. AGI-5198 shows good potency in the U87 R132H cell based assay and ~90% tumor 2-HG inhibition in the corresponding mouse xenograft model following BID dosing. AGI-5198 inhibits IDH1 R132H mutant and R132C mutant in vitro with IC50 ~0.07 μM and ~0.16 μM, respectively. Uses: Designed for use in research and industrial production. Additional or Alternative Names: AGI5198; AGI-5198; AGI 5198; IDHC35; IDH-C35; IDH C35. Product Category: Inhibitors. Appearance: White to off-white solid powder. CAS No. 1355326-35-0. Molecular formula: C27H31FN4O2. Mole weight: 462.56. Purity: >98%. IUPACName: N-cyclohexyl-2-(N-(3-fluorophenyl)-2-(2-methyl-1H-imidazol-1-yl)acetamido)-2-(o-tolyl)acetamide. Canonical SMILES: O=C(NC1CCCCC1)C(N(C2=CC=CC(F)=C2)C(CN3C=CN=C3C)=O)C4=CC=CC=C4C. Product ID: ACM1355326350. Alfa Chemistry ISO 9001:2015 Certified. |  |
| AGI-5198 | AGI-5198 is the first highly potent and selective inhibitor of IDH1 R132H/R132C mutants with IC50 of 0.07 μM/0.16 μM. Synonyms: AGI5198; AGI-5198; AGI 5198; IDHC35; IDH-C35; IDH C35. Grades: >98%. CAS No. 1355326-35-0. Molecular formula: C27H31FN4O2. Mole weight: 462.56. |  |
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