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| Product | Description | |
|---|---|---|
| AHR Antagonist 5 | AHR Antagonist 5, an effective and orally active aromatic hydrocarbon receptor (AHR) antagonist with IC50 of less than 0.5 μM. It can significantly inhibit tumor growth in combination with the checkpoint inhibitor anti-PD-1. Synonyms: BCP33104; HY-136220; CS-0120848; (R)-N-(2-(5-Fluoropyridin-3-Yl)-8-Isopropylpyrazolo[1,5-A][1,3,5]Triazin-4-Yl)-2,3,4,9-Tetrahydro-1H-Carbazol-3-Amine Trihydrochloride. Grade: ≥98% by HPLC. CAS No. 2247953-39-3. Molecular formula: C25H27Cl3FN7. Mole weight: 550.9. |  |
| AHR antagonist 5 free base | AHR antagonist 5 free base, a selective and orally active aryl hydrocarbon receptor (AHR) inhibitor, effectively blocks AHR from translocating from the cytoplasm to the nucleus. AHR antagonist 5 free base is highly selective for AHR over other receptors, transporters, and kinases. CAS No. 2247950-42-9. Molecular formula: C25H24FN7. Mole weight: 441.50. | |
| AHR antagonist 5 hemimaleate | AHR antagonist 5 hemimaleate is a potent and orally active aryl hydrocarbon receptor (AHR) antagonist with an IC50 of < 0.5 μΜ. AHR antagonist 5 hemimaleate significantly inhibits tumor growth combined with checkpoint inhibitor anti-PD-1. Molecular formula: C29H28FN7O4. Mole weight: 499.55. | |
| AhR Antagonist III, GNF351 (N-(2-(3H-Indol-3-yl)ethyl)-9-isopropyl-2-(5-methyl-3-pyridyl)-7H-purin-6-amine, N-(2-(1H-Indol-3-yl)ethyl)-9-isopropyl-2-(5-methylpyridin-3-yl)-9H-purin-6-amine) | A cell-permeable purine compound that acts as a high-affinity aryl hydrocarbon receptor (AhR) antagonist (IC50 = 62nM in mouse liver cytosol expressing humanized AhR) and lacks any agonist activity even at higher doses. Reportedly binds with high affinity to the ligand-binding pocket of AhR and blocks the binding of an array of exogenous and endogenous ligands. Shown to non-covalently interact with Ser317, His291, and Ser365 in human and with Ser311, His285, and Ser359 in mouse AhR. Represses AhR transcriptional activity via the dioxin response element (DRE)-dependent and independent mediated responses in human and mouse cells (IC50 = 8.5nM in HepG2 40/6 cells). Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 10mg. US Biological Life Sciences. |  Worldwide |
| AHR antagonist 2 | AHR antagonist 2 is a potent aryl hydrocarbon receptor (AHR) antagonist, extracted from patent WO2019101641A1, compound example 1. Synonyms: AHR antagonist 2; 2338747-54-7; SCHEMBL21001701; CSSGBPKFVJOAIZ-LBPRGKRZSA-N; AKOS040732400; MS-27306; HY-135831; CS-0114332; N-[(2S)-1-hydroxypropan-2-yl]-2-pyridin-3-yl-6-[4-(trifluoromethoxy)phenyl]pyrimidine-4-carboxamide. Grade: 99%. CAS No. 2338747-54-7. Molecular formula: C20H17F3N4O3. Mole weight: 418.37. | |
| AHR antagonist 4 | AHR antagonist 4 is a potent aryl hydrocarbon receptor (AHR) antagonist extracted from patent WO2018146010A1 (example 293; IC50 = 82.2 nM). It has anti-cancer effects. CAS No. 2242465-58-1. Molecular formula: C20H14F6N4O4. Mole weight: 488.34. | |
| BAY-218 | BAY-218 (AHR antagonist 1) is an aryl hydrocarbon receptor (AHR) antagonist. BAY-218 has AHR inhibitory activity with an IC 50 of 39.9 nM in in U87 glioblastoma cells. BAY-218 can be used for the research of cancer or conditions with dysregulated immune responses [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: AHR antagonist 1. CAS No. 2162982-11-6. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-111449. |  |
| BAY 2416964 | BAY 2416964 is a potent and orally active aryl hydrocarbon receptor (AHR) antagonist extracted from patent WO2018146010A1, example 192, has an IC 50 of 341 nM. BAY 2416964 has the potential for solid tumors treatment [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2242464-44-2. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-135829. | |
| CAY10464 | CAY10464 (AHR antagonist 7; compound 4j) is a selective and high-affinity aryl hydrocarbon receptor (AhR) antagonist with a K i of 1.4 nM [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: AHR antagonist 7. CAS No. 688348-37-0. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-112628. | |
| CH 223191 | CH 223191 is a specific and potent antagonist to the aryl hydrocarbon receptor (AhR), a ligand-dependent transcription factor that is involved in drug and xenobiotic metabolism. Unlike other AhR antagonists, it does not react with the estrogen receptor and is observed to effect AhR-dependent reporter gene expression in human, mouse, rat, and guinea pig cell lines. CH223191 is reported to exhibit AHR-independent pro-proliferative properties. Group: Biochemicals. Alternative Names: AhR Antagonist, CH223191, AGN-PC-0KP4EW, Aryl hydrocarbon receptor antagonist; 2-methyl-N- [2-methyl-4- [ (2-methylphenyl) diazenyl] phenyl] pyrazole-3-carboxamide. Grades: Highly Purified. CAS No. 301326-22-7. Pack Sizes: 10mg, 50mg. Molecular Formula: C19H19N5, Molecular Weight: 333.4. US Biological Life Sciences. | Worldwide |
| CH-223191 | CH-223191 is a potent and specific antagonist of aryl hydrocarbon receptor ( AhR ). CH-223191 inhibits TCDD-mediated nuclear translocation and DNA binding of AhR, and inhibits TCDD-induced luciferase activity with an IC 50 of 0.03 μM [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 301326-22-7. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-12684. | |
| CHD-5 | CHD-5 is a potent AhR (aryl hydrocarbon receptor) antagonist [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 289494-16-2. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-118780. | |
| Glycopyrrolate Bromide | Glycopyrrolate bromide is a muscarinic competitive antagonist used as an antispasmodic. Uses: Adjuvants, anesthesia. Synonyms: 3-[(2-Cyclopentyl-2-hydroxy-2-phenylacetyl)oxy]-1,1-dimethylpyrrolidinium Bromide; 3-Hydroxy-1,1-dimethylpyrrolidinium Bromide α-Cyclopentylmandelate; AHR-504; Asecryl; Copyrrolate; Gastrodyn; NSC 250836; NVA 237; Nodapton; Robanul; Robinul; Tarodyl; Tarodyn; Glycopyrrolate; GLYCOPYRROLATE; Glycopyrronium bromide; Gastrodyn; NVA-237; NVA237. Grade: 98%. CAS No. 596-51-0. Molecular formula: C19H28BrNO3. Mole weight: 398.33. | |
| GNF351 | GNF351 is a full aryl hydrocarbon receptor (AHR) antagonist. GNF351 competes with a photoaffinity AHR ligand for binding to the AHR with an IC50 of 62 nM. GNF351 is minimal toxicity in mouse or human keratinocytes[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1227634-69-6. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-102023. | |
| IK-175 | IK-175 is a selective and orally active aryl hydrocarbon receptor (AHR) inhibitor. IK-175 effectively blocks AHR from translocating from the cytoplasm to the nucleus. IK-175 is highly selective for AHR over other receptors, transporters, and kinases[1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: AHR antagonist 5 free base. CAS No. 2247950-42-9. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg. Product ID: HY-141609. | |
| Metergoline | Metergoline is an antagonist at 5-HT1, 5-HT2, and 5-HT7 serotonin receptors. Metergoline is an analgesic; antipyretic. Group: Biochemicals. Alternative Names: N-[[(8 β)-1,6-Dimethylergolin-8-yl]methyl]carbamic Acid Phenylmethyl Ester; [(1,6-Dimethylergolin-8 β-yl)methyl]carbamic Acid Benzyl Ester; N-Carboxy-9,10-dihydro-1-methyllysergamine Benzyl Ester; 8 β -Carbobenzyloxyamino methyl -1, 6-di methyl -10 α -ergoline; AHR 3009; Contralac; D-8 β -[ (Carbobenzoxyamino) methyl]-1, 6-dimethyl-10α -ergoline; D-N-Carbobenzoxy-dihydro-1-methyllysergamine I; FI 6337; Liserdol; MCE; Metergolin; Methergoline. Grades: Highly Purified. CAS No. 17692-51-2. Pack Sizes: 100mg. US Biological Life Sciences. | Worldwide |
| PDM2 | PDM2 is a selective, high-affinity aryl hydrocarbon receptor ( AhR ) antagonist with an K i of 1.2±0.4 nM. Uses: Scientific research. Group: Signaling pathways. CAS No. 688348-25-6. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-112629. | |
| Prochloraz | Prochloraz is an imidazole antifungal. Prochloraz is as an estrogen receptor (ER) and androgen receptor (AR) antagonist and an aromatase inhibitor with IC 50 values of 25 μM, 4 μM and 0.3 μM, respectively. Prochloraz is able to activate the aryl hydrocarbon receptor (AhR) having an EC 50 of 1 μM [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: BTS 40542. CAS No. 67747-09-5. Pack Sizes: 10 mM * 1 mL; 250 mg; 500 mg; 1 g. Product ID: HY-B0845. | |
| Stemregenin 1 | Stemregenin 1 is a potent aryl hydrocarbon receptor ( AhR ) antagonist with IC 50 of 127 nM. Uses: Scientific research. Group: Signaling pathways. Alternative Names: SR1. CAS No. 1227633-49-9. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-15001. | |
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