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| Product | Description | |
|---|---|---|
| AK-1 | ?98% (HPLC). Group: Fluorescence/luminescence spectroscopy. |  |
| AK-1 | AK-1 is a potent, specific and cell-permeable SIRT2 inhibitor (IC50 = 12.5 μM) with excellent selectivity against SIRT1 and SIRT3 (IC50 >50 μM, and >50 μM for SIRT1 and SIRT3 respectively). Synonyms: AK-1; AK 1; AK1; DA-42784; KB-120200; Y1899; J-018989; DA42784; KB120200; J018989; DA 42784; KB 120200; J 018989; 3-(azepan-1-ylsulfonyl)-N-(3-nitrophenyl)benzamide; SIRT2 Inhibitor II, AK-1; SIRT2 Inhibitor II; CHEMBL1797749; 3-(azepan-1-ylsulfonyl)-N-(3-nitrophenyl)benzamide. CAS No. 330461-64-8. Molecular formula: C19H21N3O5S. Mole weight: 403.45. |  |
| AK-1 | AK-1 is a potent, specific and cell-permeable SIRT2 inhibitor, with an IC 50 of 12.5 μM. Uses: Scientific research. Group: Signaling pathways. CAS No. 330461-64-8. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-101465. |  |
| Anti-?-Tubulin (AK-15) antibody produced in rabbit | IgG fraction of antiserum, buffered aqueous solution. Group: Fluorescence/luminescence spectroscopy. | |
| SIRT2 Inhibitor II, AK-1 - CAS 330461-64-8 | The SIRT2 Inhibitor II, AK-1, also referenced under CAS 330461-64-8, controls the biological activity of SIRT2. This small molecule/inhibitor is primarily used for Cell Structure applications. Group: Fluorescence/luminescence spectroscopy. | |
| 1-Piperidinecarboxylicacid,4-[[[(4-methylphenyl)sulfonyl]oxy]methyl]-,1,1-dimethylethyl ester | 1-Piperidinecarboxylicacid,4-[[[(4-methylphenyl)sulfonyl]oxy]methyl]-,1,1-dimethylethyl ester. Uses: Designed for use in research and industrial production. Additional or Alternative Names: 166815-96-9, N-Boc-4-(4-Toluenesulfonyloxymethyl)piperidine, N-TERT-BUTOXYCARBONYL-4-(4-TOLUENESULFONYLOXYMETHYL)PIPERIDINE, F2167-0074, tert-butyl 4-({[(4-methylphenyl)sulfonyl]oxy}methyl)piperidine-1-carboxylate, PubChem23416, AC1Q2LQW, AGN-PC-0CTN17, KSC532I5J, CTK4D2454, MolPort-003-823-749, ACT05192, ANW-50316, STL357534, ZINC02563761, AKOS005174069, AG-E-16214, MCULE-5860712597, AK-17106, BR-17106. Product Category: Heterocyclic Organic Compound. CAS No. 166815-96-9. Molecular formula: C18H27NO5S. Mole weight: 369.48. Purity: 0.96. IUPACName: tert-butyl 4-[(4-methylphenyl)sulfonyloxymethyl]piperidine-1-carboxylate. Canonical SMILES: CC1=CC=C(C=C1)S(=O)(=O)OCC2CCN(CC2)C(=O)OC(C)(C)C. Density: 1.175g/cm³. Product ID: ACM166815969. Alfa Chemistry ISO 9001:2015 Certified. Categories: 1-(tert-Butoxycarbonyl)-4-[(p-toluenesulfonyloxy)methyl]piperidine. |  |
| 2-[3-(Trifluoromethyl)phenoxy]nicotinic acid | 2-[3-(Trifluoromethyl)phenoxy]nicotinic acid. Uses: Designed for use in research and industrial production. Additional or Alternative Names: MolPort-001-772-434, CID215891, 12P-365S, LS-131059, 2-[3-(trifluoromethyl)phenoxy]nicotinic acid, Acide 2-(3-trifluoromethyl) phenoxy nicotinique [French], Acide 2-(3-trifluoromethyl) phenoxy nicotinique, AK-105/40835700, 2-(3-(Trifluoromethyl)phenoxy)-3-pyridinecarboxylic acid, 3-Pyridinecarboxylic acid, 2-(3-(trifluoromethyl)phenoxy)-, 36701-89-0. Product Category: Heterocyclic Organic Compound. CAS No. 36701-89-0. Molecular formula: C13H8F3NO3. Mole weight: 283.2. Purity: 0.96. IUPACName: 2-[3-(trifluoromethyl)phenoxy]pyridine-3-carboxylic acid. Canonical SMILES: C1=CC(=CC(=C1)OC2=C(C=CC=N2)C(=O)O)C(F)(F)F. Density: 1.421g/cm³. ECNumber: 609-284-6. Product ID: ACM36701890. Alfa Chemistry ISO 9001:2015 Certified. | |
| 4-(4-Methoxyphenyl)-5-methyl-2,4-dihydro-3H-1,2,4-triazol-3-one | 4-(4-Methoxyphenyl)-5-methyl-2,4-dihydro-3H-1,2,4-triazol-3-one. Uses: Designed for use in research and industrial production. Additional or Alternative Names: 85562-69-2, 4-(4-methoxyphenyl)-5-methyl-2,4-dihydro-3H-1,2,4-triazol-3-one, MLS000549287, AC1MZAZH, CTK5F5221, methoxyphenylmethyldihydrotriazolone, MolPort-001-758-224, HMS2364E08, SBB093486, ZINC08672155, AKOS005069658, AG-H-44387, MCULE-8454545685, RP11955, AK123727, KB-34465, SMR000168870, FT-0680092, AK-105/40836944, 12T-0819. Product Category: Heterocyclic Organic Compound. CAS No. 85562-69-2. Molecular formula: C10H11N3O2. Mole weight: 205.21. Purity: 0.96. IUPACName: 4-(4-methoxyphenyl)-3-methyl-1H-1,2,4-triazol-5-one. Canonical SMILES: CC1=NNC(=O)N1C2=CC=C(C=C2)OC. Density: 1.29g/cm³. Product ID: ACM85562692. Alfa Chemistry ISO 9001:2015 Certified. | |
| 6-Chloro-3-(1H-tetrazol-5-yl)-4H-chromen-4-one | 6-Chloro-3-(1H-tetrazol-5-yl)-4H-chromen-4-one. Uses: Designed for use in research and industrial production. Additional or Alternative Names: AK-198/09542006, 6-chloro-3-(1H-tetraazol-5-yl)-4H-chromen-4-one, 6-CHLORO-3-(1H-TETRAZOL-5-YL)-4H-CHROMEN-4-ONE, 50743-50-5, AC1LID9U, Oprea1_658704, MLS000706576, CTK4J3092, MolPort-002-818-147, HMS2737F21, AG-F-70892, MCULE-2986293684, SMR000226948, 6-chloro-3-(2H-tetrazol-5-yl)chromen-4-one. Product Category: Heterocyclic Organic Compound. CAS No. 50743-50-5. Molecular formula: C10H5ClN4O2. Mole weight: 248.625300 [g/mol]. Purity: 0.96. IUPACName: 6-chloro-3-(2H-tetrazol-5-yl)chromen-4-one. Canonical SMILES: C1=CC2=C(C=C1Cl)C(=O)C(=CO2)C3=NNN=N3. Product ID: ACM50743505. Alfa Chemistry ISO 9001:2015 Certified. | |
| a-Tosyl-(2-bromobenzyl)isocyanide | a-Tosyl-(2-bromobenzyl)isocyanide. Uses: Designed for use in research and industrial production. Additional or Alternative Names: a-Tosyl-(2-bromobenzyl) isocyanide, 936548-16-2, a-Tosyl-(2-bromobenzyl)isocyanide, alpha-Tosyl-(2-bromobenzyl) isocyanide, (2-Bromophenyl)(isocyano)methyl 4-methylphenyl sulphone, PubChem11920, CTK8E5626, MolPort-003-823-768, OR1746, alpha-Tosyl-(2-bromobenzyl)isocyanide, AKOS015919850, AB18980, 1-Bromo-2-(isocyano(tosyl)methyl)benzene, AK-17402, BR-17402, KB-47454, FT-0690265, W9629, A844666, [1-(2-BROMOPHENYL)-1-TOSYL]METHYL ISOCYANIDE. Product Category: Bromine Series. CAS No. 936548-16-2. Molecular formula: C15H12BrNO2S. Mole weight: 350.23. Purity: 0.96. IUPACName: 1-bromo-2-[isocyano-(4-methylphenyl)sulfonylmethyl]benzene. Canonical SMILES: CC1=CC=C(C=C1)S(=O)(=O)C(C2=CC=CC=C2Br)[N+]#[C-]. Product ID: ACM936548162. Alfa Chemistry ISO 9001:2015 Certified. | |
| a-Tosyl-(4-bromobenzyl)isocyanide | a-Tosyl-(4-bromobenzyl)isocyanide. Uses: Designed for use in research and industrial production. Additional or Alternative Names: 655254-61-8, a-Tosyl-(4-bromobenzyl) isocyanide, 1-bromo-4-(isocyano(tosyl)methyl)benzene, (4-Bromophenyl)(isocyano)methyl 4-methylphenyl sulphone, 4-Bromo-1-[isocyano(toluene-4-sulphonyl)]methylbenzene, 4-Bromo-1-[isocyano-(toluene-4-sulfonyl)-methyl]-benzene, a-Tosyl-(4-bromobenzyl)isocyanide, AC1MCKFP, PubChem11918, CTK5C2830, -Tosyl-(4-bromobenzyl)isocyanide, MolPort-001-756-527, ?-Tosyl-(4-bromobenzyl)isocyanide, AKOS005257327, AB18973, AG-G-46718, GL-0218, OR01701, AK-17403, BR-17403. Product Category: Bromine Series. CAS No. 655254-61-8. Molecular formula: C15H12BrNO2S. Mole weight: 350.23. Purity: 0.95. IUPACName: 1-[(4-bromophenyl)-isocyanomethyl]sulfonyl-4-methylbenzene. Canonical SMILES: CC1=CC=C(C=C1)S(=O)(=O)C(C2=CC=C(C=C2)Br)[N+]#[C-]. Product ID: ACM655254618. Alfa Chemistry ISO 9001:2015 Certified. | |
| CHEMBL2426474 | CHEMBL2426474, also called as UNC1079, the piperidine analog of UNC1021 that has binding affinity to L3MBTL3 in human G401 cells by Western blot based pulldown assay. Synonyms: CHEMBL2426474UNC1079; UNC-1079; UNC 1079.1,4-Phenylenebis(1,4'-bipiperidin-1'-ylmethanone)1418741-86-2BDBM50440571AKOS025405429CS-5532; AK-185224; HY-18373; CS 5532; AK 185224; HY 18373; CS5532; AK185224; HY183731,4-Bis(4-(piperidinyl)piperidinyl)benzamide. CAS No. 1418741-86-2. Molecular formula: C28H42N4O2. Mole weight: 466.67. | |
| NT-157 | NT-157, a selective IRS-1/2 inhibitor, has been found to influence cell migratory at some extent and could induce the inhibition of cancer cell survival. The preclinical trails has reported by TyrNovo. IC50: 0.3 to 0.8 μM. Uses: Nt-157 is a selective irs-1/2 inhibitor that has been found to influence cell migratory at some extent and could induce the inhibition of cancer cell survival. Synonyms: NT-157; NT 157; NT157; AK174915; AK 174915; AK-174915; AKOS025404921; CS-5531; CS 5531; CS5531;(4E)-2-bromo-6-hydroxy-4-[(Z)-3-sulfanyl-3-[(3,4,5-trihydroxyphenyl)methylamino]prop-2-enylidene]cyclohexa-2,5-dien-1-one. Grades: 98%. CAS No. 1384426-12-3. Molecular formula: C16H14BrNO5S. Mole weight: 410.98. | |
| Panulisib | Panulisib, also known as AK151761, is a potent and selective imidazoquinoline based PI3K inhibitor with potential anticancer activity. Synonyms: AK151761; AK 151761; AK-151761; P7170; P 7170; P-7170; AGN-PC-0BMUW9; S9WA04F921. Grades: >98%. CAS No. 1356033-60-7. Molecular formula: C27H20F3N9. Mole weight: 527.51. | |
| 1-(4-{[4-(2-Oxo-2,3-dihydro-1H-benzimidazol-1-yl)piperidin-1-yl]methyl}phenyl)-2-phenylethane-1,2-dione | Intermediate for the preparation of Akti-1/2. Group: Biochemicals. Alternative Names: 1- [4- [ [4- (2, 3-Dihydro-2-oxo-1H-benzimidazol-1-yl) -1-piperidinyl] methyl] phenyl] -2-phenyl-. Grades: Highly Purified. Pack Sizes: 50mg. US Biological Life Sciences. |  Worldwide |
| Akti-1/2 | Akti-1/2. Group: Biochemicals. Alternative Names: 1,3-Dihydro-1-[1-[[4-(6-phenyl-1H-imidazo[4,5-g]quinoxalin-7-yl)phenyl]methyl]4-piperidinyl]-2H-benzimidazol-2-one. Grades: Highly Purified. CAS No. 612847-09-3. Pack Sizes: 1mg, 2mg, 5mg, 10mg, 25mg. Molecular Formula: C34H29N7O. US Biological Life Sciences. | Worldwide |
| Akti-1/2 (1,3-Dihydro-1-[1-[[4-(6-phenyl-1H-imidazo[4,5-g]guinoxalin-7-yl)phenyl]methyl]4-piperidinyl]-2H-benzimidazol-2-one) | Allosteric Akt (PKB) inhibitors used in synergistic combination therapy for the treatment of cancer. Group: Biochemicals. Alternative Names: 1,3-Dihydro-1-[1-[[4-(6-phenyl-1H-imidazo[4,5-g]guinoxalin-7-yl)phenyl]methyl]4-piperidinyl]-2H-benzimidazol-2-one. Grades: Highly Purified. CAS No. 612847-09-3. Pack Sizes: 2mg. US Biological Life Sciences. | Worldwide |
| Akt Inhibitor, Isozyme-selective (1,3-Dihydro-1-(1-((4-(6-phenyl-1H-imidazo[4,5-g]quinoxalin-7-yl)phenyl)methyl)-4-piperidinyl)-2H-benzimidazol-2-one; Akti-1/2) | Cell-permeable. A potent and selective inhibitor of Akt1/Akt2 activity (IC?? = 58nM (Akt1), 210nM (Akt2) and 2.12uM (Akt3) in in vitro kinase assays). The inhibition appears to be pleckstrin homology (PH) domain-dependent. It does not exhibit any inhibitory effect against PH domain-lacking Akts, or other closely related AGC family kinases, PKA, PKC, and SGK, even at concentrations (50uM). Group: Biochemicals. Grades: Highly Purified. CAS No. 612847-09-3. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
| AKT inhibitor VIII | Akt Inhibitor VIII is a cell-permeable quinoxaline compound that has been shown to potently, selectively, allosterically, and reversibly inhibit Akt1, Akt2, and Akt3 activity. It does not exhibit any inhibitory effect against pleckstrin homology (PH) domain-lacking Akts, AGC family kinases, PKA, PKC or SGK. It also prevails over Akt1/Akt2-mediated resistance to chemotherapeutics in tumor cells and has been shown to block basal and stimulated phosphorylation/activation of Akt1/Akt2 in cultured cells and in mice. Synonyms: AKT inhibitor VIII; AKT-inhibitor-VIII; AKT inhibitor-8; AKT-inhibitor-8; Akt-I 1,2; Akti-1/2. Sigma-A6730. 2H-Benzimidazol-2-one, 1,3-dihydro-1-[1-[[4-(6-phenyl-1H-imidazo[4,5-g]quinoxalin-7-yl)phenyl]methyl]-4-piperidinyl]-. Grades: >98%. CAS No. 612847-09-3. Molecular formula: C34H29N7O. Mole weight: 551.64. | |
| Akt Inhibitor VIII, Isozyme-Selective, Akti-1/2 (1,3-Dihydro-1-(1-((4-(6-phenyl-1H-imidazo[4,5-g]quinoxalin-7-yl)phenyl)methyl)-4-piperidinyl)-2H-benzimidazol-2-one, Akti-1/2) | A cell-permeable, reversible, potent, and selective inhibitor of Akt1/Akt2 activity (IC50=58nM, 210nM, and 2.12uM for Akt1, Akt2, and Akt3, respectively, in in vitro kinase assays). The inhibition is reported to be pleckstrin homology (PH) domain-dependent. It does not exhibit any inhibitory effect against PH domain-lacking Akts, or other closely related AGC family kinases, PKA, PKC, and SGK, even at concentrations as high as 50uM. Overcomes Akt1/Akt2-mediated resistance to chemotherapeutics in tumor cells and is shown to block basal and stimulated phosphorylation / activation of Akt1/Akt2 both in cultured cells in vitro and in mice in vivo. Group: Biochemicals. Grades: Highly Purified. CAS No. 612847-09-3. Pack Sizes: 1mg, 5mg. US Biological Life Sciences. | Worldwide |
| Akt Inhibitor VIII, Isozyme-Selective, Akti-1/2 - CAS 612847-09-3 | Akt Inhibitor VIII, Isozyme-Selective, Akti-1/2, CAS 612847-09-3, is a cell-permeable, reversible inhibitor of Akt1/Akt2 (IC?? = 58 nM, 210 nM, & 2.12 μM for Akt1, Akt2, and Akt3, respectively). Group: Fluorescence/luminescence spectroscopy. | |
| Akt Inhibitor XIII, Isozyme-Selective, Akti2-1/2 | The Akt Inhibitor XIII, Isozyme-Selective, Akti2-1/2 controls the biological activity of Akt. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications. Group: Fluorescence/luminescence spectroscopy. | |
| InSolution Akt Inhibitor VIII, Isozyme-Selective, Akti-1/2 | The Akt Inhibitor VIII, Isozyme-Selective, Akti-1/2 controls the biological activity of Akt. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications. Group: Fluorescence/luminescence spectroscopy. | |
| PIP3 Antagonist, PITenin-7 | A cell-permeable benzoylthiourea compound that acts as a PIP3 (phosphatidylinositol-3, 4, 5-triphosphate) mimic and inhibits PI 3-K/PIP3/Akt signaling. Shown to efficiently disrupt PIP3/Akt1 PH (pleckstrin-homology) domain interaction over PIP3/PDK1 PH (IC50=13.4 and 52.3uM) in a reversible manner, and remain inactive toward PIP3/Btk, PIP3/ARNO, PIP3/GRP1 and PIP2/PLC-d/TAPP1/TAPP2 PH domains. Blocks phosphorylation of Akt-Ser473 and -Thr308 and its downstream targets, GSK-3B-Ser9 and S6-Ser235/236 and induces metabolic stress and cell death (IC50=6.6uM) in PTEN-deficient U87MG cells. Further, synergizes with Akt Inhibitor VIII, Isozyme-Selective, Akti-1/2 and Akt Inhibitor X. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| SC66, Akt Inhibitor XVIII ( (2E, 6E) -2, 6-bis (4-Pyridylmethylene) cyclohexanone) | A cell-permeable pyridine compound that selectively targets Akt, but not PLCd, PH domain, preventing Akt membrane localization / activation and rendering Akt in a conformation susceptible to ubiquitination and subsequent proteasomal degradation. Akti-1/2 competes for Akt PH domain binding and blocks SC66-induced Akt ubiquitination and proteasomal degradation. Effectively inhibits HEK293T growth both in vitro (>99 inhibition at 0.4uM) and in mice in vivo (84% of control tumor size with twice weekly i.p. dose of 30mg/kg), Synergizes with LY294002 in cell death induction in HeLa and HS-Sultan cultures in vitro. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 25mg. Molecular Formula: C??H??N?O, Molecular Weight: 276.3. US Biological Life Sciences. | Worldwide |
| Tricirbine | Triciribine is a potent AKT inhibitor and a cell-permeable tricyclic nucleoside molecule with potential antineoplastic activity. Akt-1, -2, and -3 are serine/threonine protein kinases in the phosphatidylinositol (PI3)-kinase signalling pathway that play a critical role in the regulation of cell proliferation and survival. Following recruitment of Akt to the plasma membrane, phosphorylation at threonine 308 and serine 473 (Akt-1 numbering) by phosphoinositide-dependent kinases (PDK) 1 and 2 results in full activation of the enzyme. Triciribine is a cell-permeable tricyclic nucleoside that inhibits the phosphorylation, activation, and signalling of Akt-1, -2, and -3. It does not inhibit phosphatidylinositol 3 (PI3)-Kinase or PDK1, the direct upstream activators of Akt, nor does it inhibit PKC, PKA, ERK1/2, serum- and glucocorticoid-inducible kinase, p38, STAT3, or JNK signalling pathways. Triciribine effectively inhibits growth of Akt-overexpressing human cancer cell lines in vitro with 50% inhibition at ~5-10 μM. It also inhibit growth of tumor xenografts in mice by greater than 80% at a dose of 1 mg/kg/day. Synonyms: VQD-002; VQD 002; VQD002; NSC-154020; NSC 154020; NSC154020; Triciribine; TCN-P; triciribine; Tricyclic nucleoside; Pentaazacentopthylene; API-2; Akt Inhibitor V. Grades: 99.81%. CAS No. 35943-35-2. Molecular formula: C13H16N6O4. Mole weight: 320.309. | |
| Tricirbine Phosphate | Tricirbine Phosphate is the phosphate salt of Tricirbine. Triciribine is a tricyclic nucleoside that inhibits the phosphorylation, activation, and signalling of Akt - Akt-1, Akt-2 and Akt-3. Triciribine is currently under studies of breast cancer and ovarian cancer as an antineoplastic. Synonyms: TCN-P; UNII-5L5GE3DV88; NSC-280594; C13H17N6O7P. CAS No. 61966-08-3. Molecular formula: C13H17N6O7P. Mole weight: 400.29. | |
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