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| Product | Description | |
|---|---|---|
| ALC-0315 | ALC-0315 is an ionisable aminolipid that is responsible for mRNA compaction and aids mRNA cellular delivery and its cytoplasmic release through suspected endosomal destabilization. ALC-0315 can be used to form lipid nanoparticle (LNP) delivery vehicles. Lipid-Nanoparticles have been used in the research of mRNA COVID-19 vaccine [1]. Uses: Scientific research. Group: Biochemical assay reagents. CAS No. 2036272-55-4. Pack Sizes: 10 mM * 1 mL; 25 mg; 50 mg; 100 mg; 500 mg; 1 g. Product ID: HY-138170. |  |
| ALC-0315 | ALC-0315 is a synthetic cationic lipid (or ionizable lipid). It is a colorless oily material, It has attracted attention as a component of the SARS-CoV-2 vaccine, BNT162b2, from BioNTech and Pfizer. Specifically, it is one of four components that form lipid nanoparticles (LNPs), which encapsulate and protect the otherwise fragile mRNA that is the active ingredient in these drugs. These nanoparticles promote the uptake of therapeutically effective nucleic acids such as oligonucleotides or mRNA both in vitro and in vivo. At physiological pH, ALC-0315 becomes protonated at the nitrogen atom, yielding an ammonium cation that is attracted to the messenger RNA (mRNA), which is anionic. (https://en.wikipedia.org/wiki/ALC-0315). Uses: Designed for use in research and industrial production. Additional or Alternative Names: ALC-0315; ALC 0315; ALC0315. Product Category: Others. Appearance: Colorless to light yellow oily liquid. CAS No. 2036272-55-4. Molecular formula: C48H95NO5. Mole weight: 766.29. Purity: >98%. IUPACName: [(4-Hydroxybutyl)azanediyl]di(hexane-6,1-diyl) bis(2-hexyldecanoate). Canonical SMILES: OCCCCN(CCCCCCOC(C(CCCCCC)CCCCCCCC)=O)CCCCCCOC(C(CCCCCC)CCCCCCCC)=O. Product ID: ACM2036272554-2. Alfa Chemistry ISO 9001:2015 Certified. |  |
| ALC-0315 LNP-Cap 1 EGFP mRNA | This product is a LNP prepared with ionizable lipid (ALC-0315), helper lipid, cholesterol and PEGylated lipid, encapsulating EGFP mRNA. EGFP mRNA, a common fluorescence reporter, translates into enhanced green fluorescent protein, which exhibits an excitation wavelength of 488 nm and emission at 507 nm. The loaded EGFP mRNA is capped with the CAP 1 structure. It is only for research purposes. Group: Lipid nanoparticle. |  |
| ALC-0315 LNP-Cap 1 EGFP mRNA (5-moU) | This product is a LNP prepared with ionizable lipid (ALC-0315), helper lipid, cholesterol and PEGylated lipid, encapsulating EGFP mRNA. EGFP mRNA, a common fluorescence reporter, translates into enhanced green fluorescent protein, which exhibits an excitation wavelength of 488 nm and emission at 507 nm. The loaded EGFP mRNA is capped with the CAP 1 structure and modified with 5-methoxyuridine to enhance expression and reduce immunogenicity. It is only for research purposes. Group: Lipid nanoparticle. | |
| ALC-0315 LNP-Cap 1 EGFP mRNA (m1Ψ) | This product is a LNP prepared with ionizable lipid (ALC-0315), helper lipid, cholesterol and PEGylated lipid, encapsulating EGFP mRNA. EGFP mRNA, a common fluorescence reporter, translates into enhanced green fluorescent protein, which exhibits an excitation wavelength of 488 nm and emission at 507 nm. The loaded EGFP mRNA is capped with the CAP 1 structure and modified with N1-methyl-pseudouridine to enhance expression and reduce immunogenicity. It is only for research purposes. Group: Lipid nanoparticle. | |
| ALC-0315 LNP-Cap 1 Fluc mRNA | This product is a LNP prepared with ionizable lipid (ALC-0315), helper lipid, cholesterol and PEGylated lipid, encapsulating Firefly Luciferase mRNA. Firefly Luciferase mRNA, a fluorescence reporter, encodes an enzyme that catalyzes the oxidation of luciferin to oxyluciferin, producing bioluminescence. The loaded Firefly Luciferase mRNA is capped with the CAP 1 structure. It is only for research purposes. Group: Lipid nanoparticle. | |
| ALC-0315 LNP-Cap 1 Fluc mRNA (m1Ψ) | This product is a LNP prepared with ionizable lipid (ALC-0315), helper lipid, cholesterol and PEGylated lipid, encapsulating Firefly Luciferase mRNA. Firefly Luciferase mRNA, a fluorescence reporter, encodes an enzyme that catalyzes the oxidation of luciferin to oxyluciferin, producing bioluminescence. The loaded Firefly Luciferase mRNA is capped with the CAP 1 structure and modified with N1-methyl-pseudouridine to enhance expression and reduce immunogenicity. It is only for research purposes. Group: Lipid nanoparticle. | |
| ALC-0315 LNP-Cap 1 OVA mRNA | This product is a LNP prepared with ionizable lipid (ALC-0315), helper lipid, cholesterol and PEGylated lipid, encapsulating OVA mRNA. OVA(ovalbumin) is the predominant glycoprotein in egg whites and is known for its immunogenic properties, making it an ideal model antigen for studying immune responses. The loaded OVA mRNA is capped with the CAP 1 structure. It is only for research purposes. Group: Lipid nanoparticle. | |
| ALC-0315 LNP-EGFP mRNA (m1Ψ) | This product is a LNP prepared with ionizable lipid (ALC-0315), helper lipid, cholesterol and PEGylated lipid, encapsulating EGFP mRNA. EGFP mRNA, a common fluorescence reporter, translates into enhanced green fluorescent protein, which exhibits an excitation wavelength of 488 nm and emission at 507 nm. The loaded EGFP mRNA is modified with N1-methyl-pseudouridine to enhance expression and reduce immunogenicity. It is only for research purposes. Group: Lipid nanoparticle. | |
| ALC-0315 LNP-Empty | This product is a empty LNP prepared with ALC-0315 as the ionizable lipid and can be used as a negative control to determine the optimal mRNA delivery formulation. It is only for research purposes. Group: Lipid nanoparticle. | |
| ALC-0315 LNP-Fluc mRNA | This product is a LNP prepared with ionizable lipid (ALC-0315), helper lipid, cholesterol and PEGylated lipid, encapsulating Firefly Luciferase mRNA. Firefly Luciferase mRNA, a fluorescence reporter, encodes an enzyme that catalyzes the oxidation of luciferin to oxyluciferin, producing bioluminescence. It is only for research purposes. Group: Lipid nanoparticle. | |
| ALC-0315 LNP-Fluc mRNA (m1Ψ) | This product is a LNP prepared with ionizable lipid (ALC-0315), helper lipid, cholesterol and PEGylated lipid, encapsulating Firefly Luciferase mRNA. Firefly Luciferase mRNA, a fluorescence reporter, encodes an enzyme that catalyzes the oxidation of luciferin to oxyluciferin, producing bioluminescence. The loaded Firefly Luciferase mRNA is modified with N1-methyl-pseudouridine to enhance expression and reduce immunogenicity. It is only for research purposes. Group: Lipid nanoparticle. | |
| ALC-0315 LNP-GFP mRNA | This product is a LNP prepared with ionizable lipid (ALC-0315), helper lipid, cholesterol and PEGylated lipid, encapsulating GFP mRNA. The GFP mRNA encodes the green fluorescent protein (GFP), a widely used marker for monitoring gene expression and transfection efficiency. It exhibits an excitation wavelength of 480 nm and emission at 510 nm. It is only for research purposes. Group: Lipid nanoparticle. | |
| DiD-Labeled ALC-0315 LNP-Empty | This product is a empty DiD-labeled LNP prepared with ALC-0315 as the ionizable lipid and can be used as a negative control to determine the optimal mRNA delivery formulation. It is only for research purposes. Group: Lipid nanoparticle. | |
| DiD-Labeled ALC-0315 LNP-Fluc mRNA | This product is a DiD-labeled LNP prepared with ionizable lipid (ALC-0315), helper lipid, cholesterol and PEGylated lipid, encapsulating Firefly Luciferase mRNA. Firefly Luciferase mRNA, a fluorescence reporter, encodes an enzyme that catalyzes the oxidation of luciferin to oxyluciferin, producing bioluminescence. It is only for research purposes. Group: Lipid nanoparticle. | |
| DiD-Labeled ALC-0315 LNP-GFP mRNA | This product is a DiD-labeled LNP prepared with ionizable lipid (ALC-0315), helper lipid, cholesterol and PEGylated lipid, encapsulating GFP mRNA. The GFP mRNA encodes the green fluorescent protein (GFP), a widely used marker for monitoring gene expression and transfection efficiency. It exhibits an excitation wavelength of 480 nm and emission at 510 nm. It is only for research purposes. Group: Lipid nanoparticle. | |
| DiI-Labeled ALC-0315 LNP-Empty | This product is a empty DiI-labeled LNP prepared with ALC-0315 as the ionizable lipid and can be used as a negative control to determine the optimal mRNA delivery formulation. It is only for research purposes. Group: Lipid nanoparticle. | |
| DiI-Labeled ALC-0315 LNP-Fluc mRNA | This product is a DiI-labeled LNP prepared with ionizable lipid (ALC-0315), helper lipid, cholesterol and PEGylated lipid, encapsulating Firefly Luciferase mRNA. Firefly Luciferase mRNA, a fluorescence reporter, encodes an enzyme that catalyzes the oxidation of luciferin to oxyluciferin, producing bioluminescence. It is only for research purposes. Group: Lipid nanoparticle. | |
| DiI-Labeled ALC-0315 LNP-GFP mRNA | This product is a DiI-labeled LNP prepared with ionizable lipid (ALC-0315), helper lipid, cholesterol and PEGylated lipid, encapsulating GFP mRNA. The GFP mRNA encodes the green fluorescent protein (GFP), a widely used marker for monitoring gene expression and transfection efficiency. It exhibits an excitation wavelength of 480 nm and emission at 510 nm. It is only for research purposes. Group: Lipid nanoparticle. | |
| DiO-Labeled ALC-0315 LNP-Empty | This product is a empty DiO-labeled LNP prepared with ALC-0315 as the ionizable lipid and can be used as a negative control to determine the optimal mRNA delivery formulation. It is only for research purposes. Group: Lipid nanoparticle. | |
| DiO-Labeled ALC-0315 LNP-Fluc mRNA | This product is a DiO-labeled LNP prepared with ionizable lipid (ALC-0315), helper lipid, cholesterol and PEGylated lipid, encapsulating Firefly Luciferase mRNA. Firefly Luciferase mRNA, a fluorescence reporter, encodes an enzyme that catalyzes the oxidation of luciferin to oxyluciferin, producing bioluminescence. It is only for research purposes. Group: Lipid nanoparticle. | |
| DiO-Labeled ALC-0315 LNP-GFP mRNA | This product is a DiO-labeled LNP prepared with ionizable lipid (ALC-0315), helper lipid, cholesterol and PEGylated lipid, encapsulating GFP mRNA. The GFP mRNA encodes the green fluorescent protein (GFP), a widely used marker for monitoring gene expression and transfection efficiency. It exhibits an excitation wavelength of 480 nm and emission at 510 nm. It is only for research purposes. Group: Lipid nanoparticle. | |
| DiR-Labeled ALC-0315 LNP-Empty | This product is a empty DIR-labeled LNP prepared with ALC-0315 as the ionizable lipid and can be used as a negative control to determine the optimal mRNA delivery formulation. It is only for research purposes. Group: Lipid nanoparticle. | |
| DiR-Labeled ALC-0315 LNP-Fluc mRNA | This product is a DIR-labeled LNP prepared with ionizable lipid (ALC-0315), helper lipid, cholesterol and PEGylated lipid, encapsulating Firefly Luciferase mRNA. Firefly Luciferase mRNA, a fluorescence reporter, encodes an enzyme that catalyzes the oxidation of luciferin to oxyluciferin, producing bioluminescence. It is only for research purposes. Group: Lipid nanoparticle. | |
| DiR-Labeled ALC-0315 LNP-GFP mRNA | This product is a DIR-labeled LNP prepared with ionizable lipid (ALC-0315), helper lipid, cholesterol and PEGylated lipid, encapsulating GFP mRNA. The GFP mRNA encodes the green fluorescent protein (GFP), a widely used marker for monitoring gene expression and transfection efficiency. It exhibits an excitation wavelength of 480 nm and emission at 510 nm. It is only for research purposes. Group: Lipid nanoparticle. | |
| Lung Targeted ALC-0315 LNP-Fluc mRNA (m1Ψ) | This product is a multi-component LNP prepared from ALC-0315 as the ionizable lipid. It's specifically designed for targeted delivery of Firefly Luciferase mRNA to lung. Firefly Luciferase mRNA, a fluorescence reporter, encodes an enzyme that catalyzes the oxidation of luciferin to oxyluciferin, producing bioluminescence. The loaded Firefly Luciferase mRNA is modified with N1-methyl-pseudouridine to enhance expression and reduce immunogenicity. It is only for research purposes. Group: Lipid nanoparticle. | |
| LP-01 LNP-Fluc mRNA | This product is a DIR-labeled LNP prepared with ionizable lipid (ALC-0315), helper lipid, cholesterol and PEGylated lipid, encapsulating GFP mRNA. The GFP mRNA encodes the green fluorescent protein (GFP), a widely used marker for monitoring gene expression and transfection efficiency. It exhibits an excitation wavelength of 480 nm and emission at 510 nm. It is only for research purposes. Group: Lipid nanoparticle. | |
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