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| Product | Description | |
|---|---|---|
| ALC-0315 | ALC-0315 is an ionisable aminolipid that is responsible for mRNA compaction and aids mRNA cellular delivery and its cytoplasmic release through suspected endosomal destabilization. ALC-0315 can be used to form lipid nanoparticle (LNP) delivery vehicles. Lipid-Nanoparticles have been used in the research of mRNA COVID-19 vaccine [1]. Uses: Scientific research. Group: Biochemical assay reagents. CAS No. 2036272-55-4. Pack Sizes: 10 mM * 1 mL; 25 mg; 50 mg; 100 mg; 500 mg; 1 g. Product ID: HY-138170. |  |
| ALC-0315 | ALC-0315 is a synthetic cationic lipid (or ionizable lipid). It is a colorless oily material, It has attracted attention as a component of the SARS-CoV-2 vaccine, BNT162b2, from BioNTech and Pfizer. Specifically, it is one of four components that form lipid nanoparticles (LNPs), which encapsulate and protect the otherwise fragile mRNA that is the active ingredient in these drugs. These nanoparticles promote the uptake of therapeutically effective nucleic acids such as oligonucleotides or mRNA both in vitro and in vivo. At physiological pH, ALC-0315 becomes protonated at the nitrogen atom, yielding an ammonium cation that is attracted to the messenger RNA (mRNA), which is anionic. (https://en.wikipedia.org/wiki/ALC-0315). Uses: Designed for use in research and industrial production. Additional or Alternative Names: ALC-0315; ALC 0315; ALC0315. Product Category: Others. Appearance: Colorless to light yellow oily liquid. CAS No. 2036272-55-4. Molecular formula: C48H95NO5. Mole weight: 766.29. Purity: >98%. IUPACName: [(4-Hydroxybutyl)azanediyl]di(hexane-6,1-diyl) bis(2-hexyldecanoate). Canonical SMILES: OCCCCN(CCCCCCOC(C(CCCCCC)CCCCCCCC)=O)CCCCCCOC(C(CCCCCC)CCCCCCCC)=O. Product ID: ACM2036272554-2. Alfa Chemistry ISO 9001:2015 Certified. |  |
| ALC-0315 | Cas No. 2036272-55-4. |  |
| Lipid ALC-0315 | ALC-0315 can be used to form lipid nanoparticle (LNP, non-viral gene delivery system). Synonyms: ALC-0315; ((4-Hydroxybutyl)azanediyl)bis(hexane-6,1-diyl) bis(2-hexyldecanoate). Grades: >98%. CAS No. 2036272-55-4. Molecular formula: C48H95NO5. Mole weight: 766.27. | |
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