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| Product | Description | |
|---|---|---|
| Alectinib | Alectinib (CH5424802) is a potent, selective, and orally available ALK inhibitor with an IC 50 of 1.9 nM and a K d value of 2.4 nM (in an ATP-competitive manner), and also inhibits ALK F1174L and ALK R1275Q with IC 50 s of 1 nM and 3.5 nM, respectively [1]. Alectinib demonstrates effective central nervous system (CNS) penetration [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: CH5424802; RO5424802; RG7853. CAS No. 1256580-46-7. Pack Sizes: 5 mg; 10 mg; 50 mg; 100 mg; 200 mg. Product ID: HY-13011. |  |
| Alectinib | Alectinib, marketed as Alecensa, is an oral drug that blocks the activity of anaplastic lymphoma kinase (ALK) and is used to treat non-small-cell lung cancer (NSCLC). Alectinib has a low potential for interactions. While it is metabolised by the liver enzyme CYP3A4, and blockers of this enzyme accordingly increase its concentrations in the body, they also decrease concentrations of the active metabolite M4, resulting in only a small overall effect. Conversely, CYP3A4 inducers decrease alectinib concentrations and increase M4 concentrations. Interactions via other CYP enzymes and transporter proteins cannot be excluded but are unlikely to be of clinical significance. Synonyms: CH-5424802; CH5424802; CH 5424802; AF-802; RG-7853; RO5424802. Grades: ≥95%. CAS No. 1256580-46-7. Molecular formula: C30H34N4O2. Mole weight: 482.62. |  |
| Alectinib | Alectinib. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: 9-ethyl-6,6-dimethyl-8-(4-morpholinopiperidin-1-yl)-11-oxo-6,11-dihydro-5H-benzo[b]carbazole-3-carbonitrile. CAS No. 1256580-46-7. Molecular formula: C30H34N4O2. Mole weight: 482.62. Catalog: APB1256580467. |  |
| Alectinib Hydrochloride | Alectinib Hydrochloride (CH5424802 Hydrochloride; RO5424802 Hydrochloride; AF-802 Hydrochloride) is a potent, selective, and orally available ALK inhibitor with an IC 50 of 1.9 nM and a K d value of 2.4 nM (in an ATP-competitive manner), and also inhibits ALK F1174L and ALK R1275Q with IC 50 s of 1 nM and 3.5 nM, respectively [1]. Alectinib demonstrates effective central nervous system (CNS) penetration [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: CH5424802 Hydrochloride; RO5424802 Hydrochloride; AF-802 Hydrochloride. CAS No. 1256589-74-8. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 200 mg. Product ID: HY-13011A. | |
| Alectinib Impurity 1 | Alectinib Impurity 1. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: 9-ethyl-8-(4-((2-hydroxyethyl)amino)piperidin-1-yl)-6,6-dimethyl-11-oxo-6,11-dihydro-5H-benzo[b]carbazole-3-carbonitrile. CAS No. 1256585-04-2. Molecular formula: C28H32N4O2. Mole weight: 456.58. Catalog: APB1256585042. | |
| Alectinib Impurity 10 | Alectinib Impurity 10. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: 6-cyano-2-(2-(4-ethyl-3-(4-morpholinopiperidin-1-yl)phenyl)propan-2-yl)-1H-indole-3-carboxylic acid. CAS No. 1256584-78-7. Molecular formula: C30H36N4O3. Mole weight: 500.63. Catalog: APB1256584787. | |
| Alectinib Impurity 11 | Alectinib Impurity 11. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: 9-ethyl-6,6-dimethyl-11-oxo-8-(1,4-dioxa-8-azaspiro[4.5]decan-8-yl)-6,11-dihydro-5H-benzo[b]carbazole-3-carbonitrile. CAS No. 1256584-81-2. Molecular formula: C28H29N3O3. Mole weight: 455.55. Catalog: APB1256584812. | |
| Alectinib Impurity 12 | Alectinib Impurity 12. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: 9-ethyl-6,6-dimethyl-11-oxo-8-(4-oxopiperidin-1-yl)-6,11-dihydro-5H-benzo[b]carbazole-3-carbonitrile. CAS No. 1256584-83-4. Molecular formula: C26H25N3O2. Mole weight: 411.50. Catalog: APB1256584834. | |
| Alectinib Impurity 13 | Alectinib Impurity 13. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: 9-ethyl-8-iodo-6,6-dimethyl-11-oxo-6,11-dihydro-5H-benzo[b]carbazole-3-carbonitrile. CAS No. 1256584-80-1. Molecular formula: C21H17IN2O. Mole weight: 440.28. Catalog: APB1256584801. | |
| Alectinib Impurity 14 | Alectinib Impurity 14. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: 2-(4-ethyl-3-iodophenyl)-2-methylpropanoic acid. CAS No. 1256584-73-2. Molecular formula: C12H15IO2. Mole weight: 318.15. Catalog: APB1256584732. | |
| Alectinib Impurity 15 | Alectinib Impurity 15. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: 2-(4-ethylphenyl)-2-methylpropanoic acid. CAS No. 1247119-83-0. Molecular formula: C12H16O2. Mole weight: 192.25. Catalog: APB1247119830. | |
| Alectinib Impurity 16 | Alectinib Impurity 16. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: 2-methyl-2-(4-vinylphenyl)propanoic acid. CAS No. 1256584-72-1. Molecular formula: C12H14O2. Mole weight: 190.24. Catalog: APB1256584721. | |
| Alectinib Impurity 2 | Alectinib Impurity 2. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: 8-(4-aminopiperidin-1-yl)-9-ethyl-6,6-dimethyl-11-oxo-6,11-dihydro-5H-benzo[b]carbazole-3-carbonitrile. CAS No. 1256585-14-4. Molecular formula: C26H28N4O. Mole weight: 412.53. Catalog: APB1256585144. | |
| Alectinib Impurity 4 | Alectinib Impurity 4. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: 9-bromo-8-hydroxy-6,6-dimethyl-11-oxo-6,11-dihydro-5H-benzo[b]carbazole-3-carbonitrile. CAS No. 1256579-06-2. Molecular formula: C19H13BrN2O2. Mole weight: 381.22. Catalog: APB1256579062. | |
| Alectinib Impurity 4 | Alectinib Impurity 4. Uses: For analytical and research use. Group: Impurity standards. CAS No. 1256585-15-5. Molecular formula: C30H26D8N4O2. Mole weight: 490.68. Catalog: APB1256585155. | |
| Alectinib Impurity 5 | Alectinib Impurity 5. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: tert-butyl 4-(4-ethyl-3-iodophenyl)-4-methyl-3-oxopentanoate. CAS No. 1256584-74-3. Molecular formula: C18H25IO3. Mole weight: 416.29. Catalog: APB1256584743. | |
| Alectinib Impurity 6 | Alectinib Impurity 6. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: 6-bromo-7-methoxy-1,1-dimethyl-3,4-dihydronaphthalen-2(1H)-one. CAS No. 1256578-99-0. Molecular formula: C13H15BrO2. Mole weight: 283.16. Catalog: APB1256578990. | |
| Alectinib Impurity 7 | Alectinib Impurity 7. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: tert-butyl 6-cyano-2-(2-(4-ethyl-3-iodophenyl)propan-2-yl)-1H-indole-3-carboxylate. CAS No. 1256584-75-4. Molecular formula: C25H27IN2O2. Mole weight: 514.40. Catalog: APB1256584754. | |
| Alectinib Impurity 8 | Alectinib Impurity 8. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: tert-butyl 6-cyano-2-(2-(4-ethyl-3-(4-morpholinopiperidin-1-yl)phenyl)propan-2-yl)-1H-indole-3-carboxylate. CAS No. 1256698-41-5. Molecular formula: C34H44N4O3. Mole weight: 556.74. Catalog: APB1256698415. | |
| Alectinib Impurity 8 (Hydrochloride) | Alectinib Impurity 8 (Hydrochloride). Uses: For analytical and research use. Group: Impurity standards. Alternative Names: tert-butyl 6-cyano-2-(2-(4-ethyl-3-(4-morpholinopiperidin-1-yl)phenyl)propan-2-yl)-1H-indole-3-carboxylate hydrochloride. CAS No. 1256584-77-6. Molecular formula: C34H44N4O3·HCl. Mole weight: 593.21. Catalog: APB1256584776. | |
| Alectinib Impurity 9 | Alectinib Impurity 9. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: tert-butyl 6-cyano-2-(2-(4-ethyl-3-iodophenyl)propan-2-yl)benzofuran-3-carboxylate. CAS No. 1256585-29-1. Molecular formula: C25H26INO3. Mole weight: 515.38. Catalog: APB1256585291. | |
| 2-?(4-?Ethyl-?3-?iodophenyl)?-?2-?methylpropanoic Acid | 2-?(4-?Ethyl-?3-?iodophenyl)?-?2-?methylpropanoic Acid is an intermediate of Alectinib (C183360), a highly selective and potent anaplastic lymphoma kinase (ALK) inhibitor capable of blocking the resistant gatekeeper mutant, which results in reduced cell growth. Group: Biochemicals. Grades: Highly Purified. CAS No. 1256584-73-2. Pack Sizes: 10mg, 50mg. Molecular Formula: C12H15IO2, Molecular Weight: 318.149999999999. US Biological Life Sciences. |  Worldwide |
| 2-?(4-?Ethylphenyl)?-?2-?methylpropanoic Acid | 2-?(4-?Ethylphenyl)?-?2-?methylpropanoic Acid an intermediate of Alectinib (C183360), a highly selective and potent anaplastic lymphoma kinase (ALK) inhibitor capable of blocking the resistant gatekeeper mutant, which results in reduced cell growth. Group: Biochemicals. Grades: Highly Purified. CAS No. 1247119-83-0. Pack Sizes: 25mg, 50mg. Molecular Formula: C12H16O2, Molecular Weight: 192.25. US Biological Life Sciences. | Worldwide |
| 2-?Methyl-?2-? (4-?vinylphenyl) ?propanoic Acid | 2-?Methyl-?2-? (4-?vinylphenyl) ?propanoic Acid is an intermediate of Alectinib (C183360), a highly selective and potent anaplastic lymphoma kinase (ALK) inhibitor capable of blocking the resistant gatekeeper mutant, which results in reduced cell growth. Group: Biochemicals. Grades: Highly Purified. CAS No. 1256584-72-1. Pack Sizes: 1mg, 5mg. Molecular Formula: C12H14O2, Molecular Weight: 190.24. US Biological Life Sciences. | Worldwide |
| CH5424802 Hydrochloride | CH5424802 Hcl (AF 802 Hcl; Alectinib Hcl) is a potent ALK inhibitor with IC50 of 1.9 nM, sensitive to L1196M mutation. Synonyms: Alectinib Hydrochloride; AF-802 Hydrochloride; CH-5424802 Hydrochloride; RG-7853 Hydrochloride; RO-5424802 Hydrochloride; AF 802 Hydrochloride; CH 5424802 Hydrochloride; RG 7853 Hydrochloride; RO 5424802 Hydrochloride; AF802 Hydrochloride; CH5424802 Hydrochloride; RG7853 Hydrochloride; RO5424802 Hydrochloride. Grades: >98%. CAS No. 1256589-74-8. Molecular formula: C30H35ClN4O2. Mole weight: 519.08. | |
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