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| Product | Description | |
|---|---|---|
| Alisertib | Alisertib Inhibitor. Uses: Scientific use. Product Category: T2241. CAS No. 1028486-01-2. |  |
| Alisertib | Alisertib (MLN 8237) is an orally active and selective Aurora A kinase inhibitor ( IC 50 =1.2 nM), which binds to Aurora A kinase resulting in mitotic spindle abnormalities, mitotic accumulation. Alisertib (MLN 8237) induces apoptosis and autophagy through targeting the AKT/mTOR/AMPK/p38 pathway in leukemic cells. Antitumor activity [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: MLN 8237. CAS No. 1028486-01-2. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg; 200 mg; 500 mg. Product ID: HY-10971. |  |
| Alisertib | Alisertib. Uses: For analytical and research use. Group: Impurity standards. CAS No. 1028486-01-2. Molecular formula: C27H20ClFN4O4. Mole weight: 518.93. Catalog: APB1028486012. |  |
| Alisertib | MLN8237 is a second-generation, orally bioavailable, highly selective small molecule inhibitor of the serine/threonine protein kinase Aurora A kinase with potential antineoplastic activity. Aurora kinase inhibitor MLN8237 binds to and inhibits Aurora A kinase, which may result in disruption of the assembly of the mitotic spindle apparatus, disruption of chromosome segregation, and inhibition of cell proliferation. Synonyms: MLN8237; MLN-8237; MLN 8237; alisertib. Benzoic acid, 4-[[9-chloro-7-(2-fluoro-6-methoxyphenyl)-5H-pyrimido[5,4-d][2]benzazepin-2-yl]amino]-2-methoxy-. Grade: 0.98. CAS No. 1028486-01-2. Molecular formula: C27H20ClFN4O4. Mole weight: 518.9. |  |
| Alisertib sodium | Alisertib sodium is a salt of Alisertib which is an inhibitor of Aurora A kinase with potential antineoplastic activity. Alisertib sodium induces apoptosis and autophagy through targeting the AKT/mTOR/AMPK/p38 pathway in leukemic cells. Synonyms: MLN 8237 sodium; Alisertib sodium anhydrous; Benzoic acid, 4-((9-chloro-7-(2-fluoro-6-methoxyphenyl)-5H-pyrimido(5,4-d)(2)benzazepin-2-yl)amino)-2-methoxy-, sodium salt (1:1). CAS No. 1028486-06-7. Molecular formula: C27H19ClFN4NaO4. Mole weight: 540.90. | |
| Aurkin A | Aurkin A is an allosteric inhibitor for the interaction between Aurora A Kinase (also known also Aurka) and TPX2, through targeting the TPX2 binding sites with Kd of 3.77 ?M. Aurkin A can disrupt polyploidy induced by Alisertib (HY-10971) and increase apoptosis of tumor cells. Aurkin A can be used in research on mitosis and cancer[1][2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1534060-58-6. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-125956. | |
| JB170 | JB170 is a potent and highly specific PROTAC-mediated AURORA-A (Aurora Kinase) degrader (DC50=28 nM) by linking Alisertib, to the Cereblon-binding molecule Thalidomide. JB170 preferentially binds AURORA-A (EC50=193 nM) over AURORA-B (EC50=1.4 μM). JB170-mediated S-phase arrest is caused specifically by AURORA-A depletion. JB170 has excellent ability to inhibit non-catalytic function of AURORA-A kinase[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2705844-82-0. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-141512. | |
| MLN 8237 | Antagonist of Aurora A serine/threonine protein kinase; antineoplastic. Group: Biochemicals. Alternative Names: 4-[[9-Chloro-7-(2-fluoro-6-methoxyphenyl)-5H-pyrimido[5,4-d][2]benzazepin-2-yl]amino]-2-methoxy-benzoic acid; Alisertib. Grades: Highly Purified. CAS No. 1028486-01-2. Pack Sizes: 10mg. Molecular Formula: C27H20ClFN4O4, Molecular Weight: 518.92. US Biological Life Sciences. |  Worldwide |
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