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| Product | Description | |
|---|---|---|
| Alisol B 23-acetate | Alisol B 23-acetate. Group: Biochemicals. CAS No. 26575-95-1. Pack Sizes: 5mg. US Biological Life Sciences. |  Worldwide |
| Alisol B 23-acetate | Alisol B acetate is a triterpene from Rhizoma Alismatis (rhizomes of Alisma plantago-aquatica). It induces apoptosis in human prostate cancer cells. It produces protective effect against ANIT-induced hepatotoxity and cholestasis, due to FXR-mediated regul. Synonyms: (23S,24R)-24,25-Epoxy-11b,23-dihydroxy-8a,9b,14b-dammar-13(17)-en-3-one 23-acetate; Alisol B 23-acetate; (8α,9β,14β,23S,24R)-11β-Hydroxy-23-acetoxy-24,25-epoxy-5α-dammara-13(17)-ene-3-one; 23-Acetylalismol B; 23-O-Acetylalisol B; Alisol B monoacetate. Grade: >98%. CAS No. 26575-95-1. Molecular formula: C32H50O5. Mole weight: 514.74. |  |
| Alisol B 23-Acetate | Alisol B 23-acetate (23-Acetylalismol B), a natural triterpenoid, produces protective effects against EE-induced cholestasis, due to FXR-mediated gene regulation.IC50 Value:Target: Anti-hepatotoxic natural product.In vitro: Alisol-B 23-acetate has an effect on FXR activation in a dose-dependent manner using luciferase reporter assay in HepG2 cells.In vivo: In alisol B 23-acetate-treated mice, the changes in transporters and enzymes, as well as ameliorative liver histology were abrogated by FXR antagonist guggulsterone. Alisol B 23-acetate treatment in a dose-dependent manner resulted in protection against hepatotoxicity induced by CCl4via FXR activation. Through FXR activation, alisol B 23-acetate promoted hepatocyte proliferation via an induction in hepatic levels of FoxM1b, Cyclin D1 and Cyclin B1. Alisol B 23-acetate also reduced hepatic bile acids through a decrease in hepatic uptake transporter Ntcp, bile acid synthetic enzymes Cyp7a1, Cyp8b1, and an increase in efflux transporter Bsep, Mrp2 expression. In addition, alisol B 23-acetate induced the expression of STAT3 phosphorylation, and STAT3 target genes Bcl-xl and SOCS3, resulting in decreased hepatocyte apoptosis. Uses: Designed for use in research and industrial production. Product Category: Inhibitors. Appearance: White powder. CAS No. 26575-95-1. Molecular formula: C32H50O5. Mole weight: 514.8. Purity: 0.98. IUPACName: [1-(3,3-dimethyloxiran-2-yl)-3-[(8S,1 |  |
| Alisol B,23-acetate (23-O-Acetylalisol B, Alisol, B Acetate) | Alisol B,23-acetate (23-O-Acetylalisol B, Alisol, B Acetate). Group: Biochemicals. Alternative Names: 23-O-Acetylalisol B; Alisol B,23-acetate. Grades: Plant Grade. CAS No. 26575-95-1. Pack Sizes: 20mg. Molecular Formula: C32H50O5, Molecular Weight: 514.736. US Biological Life Sciences. | Worldwide |
| Alisol C 23-acetate | Alisol C 23-acetate is derived from the tubers of a traditional Chinese medicine Alisma plantago-aquatica Linn. Synonyms: [(1S,3R)-1-[(2R)-3,3-dimethyloxiran-2-yl]-3-[(5R,8S,9S,10S,11S,14R)-11-hydroxy-4,4,8,10,14-pentamethyl-3,16-dioxo-2,5,6,7,9,11,12,15-octahydro-1H-cyclopenta[a]phenanthren-17-yl]butyl] acetate Alisol C monoacetate Alisol C (23-acetate) 26575-93-9 23-Acetyl. Grade: >98%. CAS No. 26575-93-9. Molecular formula: C32H48O6. Mole weight: 528.72. | |
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