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| Product | Description | |
|---|---|---|
| Alisol B 23-acetate | Alisol B 23-acetate. Group: Biochemicals. CAS No. 26575-95-1. Pack Sizes: 5mg. US Biological Life Sciences. |  Worldwide |
| Alisol B 23-Acetate | Alisol B 23-acetate (23-Acetylalismol B), a natural triterpenoid, produces protective effects against EE-induced cholestasis, due to FXR-mediated gene regulation.IC50 Value:Target: Anti-hepatotoxic natural product.In vitro: Alisol-B 23-acetate has an effect on FXR activation in a dose-dependent manner using luciferase reporter assay in HepG2 cells.In vivo: In alisol B 23-acetate-treated mice, the changes in transporters and enzymes, as well as ameliorative liver histology were abrogated by FXR antagonist guggulsterone. Alisol B 23-acetate treatment in a dose-dependent manner resulted in protection against hepatotoxicity induced by CCl4via FXR activation. Through FXR activation, alisol B 23-acetate promoted hepatocyte proliferation via an induction in hepatic levels of FoxM1b, Cyclin D1 and Cyclin B1. Alisol B 23-acetate also reduced hepatic bile acids through a decrease in hepatic uptake transporter Ntcp, bile acid synthetic enzymes Cyp7a1, Cyp8b1, and an increase in efflux transporter Bsep, Mrp2 expression. In addition, alisol B 23-acetate induced the expression of STAT3 phosphorylation, and STAT3 target genes Bcl-xl and SOCS3, resulting in decreased hepatocyte apoptosis. Uses: Designed for use in research and industrial production. Product Category: Inhibitors. Appearance: White powder. CAS No. 26575-95-1. Molecular formula: C32H50O5. Mole weight: 514.8. Purity: 0.98. IUPACName: [1-(3,3-dimethyloxiran-2-yl)-3-[(8S,1 |  |
| Alisol B,23-acetate (23-O-Acetylalisol B, Alisol, B Acetate) | Alisol B,23-acetate (23-O-Acetylalisol B, Alisol, B Acetate). Group: Biochemicals. Alternative Names: 23-O-Acetylalisol B; Alisol B,23-acetate. Grades: Plant Grade. CAS No. 26575-95-1. Pack Sizes: 20mg. Molecular Formula: C32H50O5, Molecular Weight: 514.736. US Biological Life Sciences. | Worldwide |
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