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| Product | Description | |
|---|---|---|
| Alofanib | Alofanib, also known as RPT835, is a potent and selective allosteric inhibitor of FGFR2 with potential anticancer activity. Alofanib blocks the extracellular part of the receptor and prevents its binding with the ligand. Alofanib suppressed proliferation of endothelial cells, their migration activity, and ability to form vessellike structures in vitro and significantly decreased the number of microvessels in Matrigel implant and in ovarian cancer (SKOV-3) xenograft in vivo. RPT835 potently inhibited growth of KATO III gastric cancer cells expressing FGFR2, with GI50 value of 10 nmol/L. Uses: Designed for use in research and industrial production. Additional or Alternative Names: RPT835; RPT-835; RPT 835; Alofanib. Product Category: Inhibitors. Appearance: Solid powder. CAS No. 1612888-66-0. Molecular formula: C19H15N3O6S. Mole weight: 413.4. Purity: >98%. IUPACName: 3-(N-(4-methyl-2-nitro-5-(pyridin-3-yl)phenyl)sulfamoyl)benzoic acid. Canonical SMILES: O=[N+](C1=CC(C)=C(C2=CC=CN=C2)C=C1NS(=O)(C3=CC(C(O)=O)=CC=C3)=O)[O-]. Product ID: ACM1612888660. Alfa Chemistry ISO 9001:2015 Certified. |  |
| Alofanib | Alofanib, also known as RPT835, is a potent and selective allosteric inhibitor of FGFR2 with potential anticancer activity. Alofanib blocks the extracellular part of the receptor and prevents its binding with the ligand. Synonyms: RPT835; RPT-835; RPT 835; Alofanib. Grades: 95%. CAS No. 1612888-66-0. Molecular formula: C19H15N3O6S. Mole weight: 413.404. |  |
| Alofanib | Alofanib (RPT835) is a potent and selective allosteric inhibitor of fibroblast growth factor receptor 2 ( FGFR2 ). Anticancer and antiangiogenic activity [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: RPT835. CAS No. 1612888-66-0. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-17601. |  |
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