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| Product | Description | |
|---|---|---|
| Alrizomadlin | Alrizomadlin (APG-115) is an orally active MDM2 protein inhibitor binding to MDM2 protein with IC 50 and K i values of 3.8 nM and 1 nM, respectively [1]. Alrizomadlin blocks the interaction of MDM2 and p53 and induces cell-cycle arrest and apoptosis in a p53-dependent manner [2] [3]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: APG-115; AA-115. CAS No. 1818393-16-6. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-101518. |  |
| Alrizomadlin | Alrizomadlin is a highly potent and chemically stable E3 ubiquitin-protein ligase Mdm2 (Hdm2) inhibitor. It is used in the treatment and prevention of osteoarthritis. Synonyms: APG-115; AA-115; 4-((3'R,4'S,5'R)-6''-Chloro-4'-(3-chloro-2-fluorophenyl)-1'-ethyl-2''-oxodispiro[cyclohexane-1,2'-pyrrolidine-3',3''-indoline]-5'-carboxamido)bicyclo[2.2.2]octane-1-carboxylic acid; APG115; APG 115; NSC831270. Grade: >98%. CAS No. 1818393-16-6. Molecular formula: C34H38Cl2FN3O4. Mole weight: 642.59. |  |
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