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Amifostine is a phosphorylated aminosulfhydryl compound. After dephosphorylation of amifostine by alkaline phosphatase to an active free sulfhydryl (thiol) metabolite, the thiol metabolite binds to and detoxifies cytotoxic platinum-containing metabolites of cisplatin and scavenges free radicals induced by cisplatin and ionizing radiation. The elevated activity of this agent in normal tissues results from both the relative abundance of alkaline phosphatase in normal tissues and the greater vascularity of normal tissues compared to tumor tissues. Uses: Radiation-protective agents. Synonyms: Ethyol; WR2721; WR 2721; WR-2721. Grade: >98%. CAS No. 20537-88-6. Molecular formula: C5H15N2O3PS. Mole weight: 214.22.
Amifostine
Amifostine (WR2721) is a broad-spectrum cytoprotective agent and a radioprotector. Amifostine selectively protects normal tissues from damage caused by radiation and chemotherapy. Amifostine is potent hypoxia-inducible factor-α1 (HIF-α1) and p53 inducer. Amifostine protects cells from damage by scavenging oxygen-derived free radicals. Amifostine reduces renal toxicity and has antiangiogenic action [1] [2] [3] [4]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: WR2721. CAS No. 20537-88-6. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 200 mg. Product ID: HY-B0639.
Amifostine
It is a thiophosphate derivative of cysteamine; provides normal cells with selective protection against the toxic effects of cancer chemotherapy and radiation treatment. Group: Biochemicals. Alternative Names: 2-[(3-Aminopropyl)-amino]ethanethiol Dihydrogen Phosphate; Phosphorothioic Acid S-[2-[ (3-Aminopropyl) amino]ethyl]ester; Ethiofos; Gammaphos; SAPEP; CSC-296961; Ethyol. Grades: Highly Purified. CAS No. 20537-88-6. Pack Sizes: 10mg, 100mg. US Biological Life Sciences.
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Amifostine
United States Pharmacopeia (USP) Reference Standard. Group: Pharmacopeia & metrological institutes standards.
Amifostine disulfide
United States Pharmacopeia (USP) Reference Standard. Group: Pharmacopeia & metrological institutes standards.
Amifostine hydrate
Amifostine hydrate is a radiation-protective agent. Synonyms: Amifostinum; Amifostine monohydrate; Amifostinum; Amifostina. CAS No. 63717-27-1. Molecular formula: C5H15N2O3PS.H2O. Mole weight: 232.235.
Amifostine Impurity 10
Amifostine Impurity 10. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: 2-(bis(3-aminopropyl)amino)ethanol. CAS No. 17002-55-0. Molecular formula: C8H21N3O. Mole weight: 175.27. Catalog: APB17002550.
Amifostine Impurity 14
Amifostine Impurity 14. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: 2,2'-(propane-1,3-diylbis(azanediyl))diethanol. CAS No. 10563-27-6. Molecular formula: C7H18N2O2. Mole weight: 162.23. Catalog: APB10563276.
Amifostine Impurity 15
Amifostine Impurity 15. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: N1,N3-bis(2-bromoethyl)propane-1,3-diamine dihydrobromide. CAS No. 10297-31-1. Molecular formula: C7H16Br2N2·2HBr. Mole weight: 449.85. Catalog: APB10297311.
Amifostine Impurity 16
Amifostine Impurity 16. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: N1,N1'-(disulfanediylbis(ethane-2,1-diyl))bis(propane-1,3-diamine) tetrahydrochloride. CAS No. 10027-65-3. Molecular formula: C10H26N4S2·4HCl. Mole weight: 412.314. Catalog: APB10027653.
Amifostine thiol
Amifostine Thiol is a metabolite of Amifostine. Amifostine thiol activates p53 through a JNK-dependent signaling pathway. Synonyms: 2-[(3-Aminopropyl)amino]-ethanethiol; N-(2-Mercaptoethyl)-1,3-diaminopropane; NSC 647527; WR 1065. Grade: 95%. CAS No. 31098-42-7. Molecular formula: C5H14N2S. Mole weight: 134.25.
Amifostine thiol
United States Pharmacopeia (USP) Reference Standard. Group: Pharmacopeia & metrological institutes standards.
Amifostine Thiol-[d6] Dihydrochloride
Amifostine Thiol Dihydrochloride-[d6] is the isotope labelled analog of Amifostine Thiol Dihydrochloride, which is a metabolite of amifostine. Amifostine thiol activates p53 through a JNK-dependent signaling pathway. Synonyms: 2-[(3-Aminopropyl)amino]ethanethiol Hydrochloride-d6; WR 1065-d6; Amifostine Thiol-d6 Dihydrochloride. Molecular formula: C5H8D6N2S.2HCl. Mole weight: 213.2.
Amifostine Thiol Dihydrochloride
A metabolite of Amifostine. Group: Biochemicals. Alternative Names: 2-[ (3-Aminopropyl) amino]ethanethiol Hydrochloride; WR 1065. Grades: Highly Purified. CAS No. 14653-77-1. Pack Sizes: 10mg. US Biological Life Sciences.
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Amifostine Thiol Dihydrochloride-d4
Amifostine Thiol Dihydrochloride-d4 is the isotope labelled analog of Amifostine Thiol Dihydrochloride, which is a metabolite of amifostine. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 1mg, 10mg. Molecular Formula: C5H12D4Cl2N2S, Molecular Weight: 211.19. US Biological Life Sciences.
2- (3- ( (2- (Tritylthio) ethyl) amino) propyl) isoindoline-1, 3-dione-d6 is an intermediate in the synthesis of Amifostine Thiol Dihydrochloride-d6 (A576823), which is a metabolite of amifostine. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 2.5mg, 5mg. Molecular Formula: C32H24D6N2O2S. US Biological Life Sciences.
2-[(3-Aminopropyl)-amino]ethanethiol dihydrogen phosphate. Group: Biochemicals. Alternative Names: Amifostine; Phosphorothioic acid S-[2-[ (3-aminopropyl) amino]ethyl]ester; Ethiofos. Grades: Highly Purified. CAS No. 20537-88-6. Pack Sizes: 1g, 2g, 5g. Molecular Formula: C5H15N2O3PS. US Biological Life Sciences.
Worldwide
2- (3-Aminopropylamino) ethanol
2- (3-Aminopropylamino) ethanol is the hydroxy analogue of WR-1065 (A576820), a metabolite of Amifostine (A576810). Amifostine is an organic thiophosphate that has the ability to protect a broad range of tissues from cytotoxicity (e.g. from chemotherapeutic agents) without inducing an antitumour response. 2- (3-Aminopropylamino) ethanol is also used as an nucleophilic tag in the detection of human butyrylcholinesterase adducts. Group: Biochemicals. Grades: Highly Purified. CAS No. 4461-39-6. Pack Sizes: 1g, 5g. Molecular Formula: C5H14N2O. US Biological Life Sciences.
Worldwide
2-(3-Aminopropylamino)ethanol
2-(3-Aminopropylamino)ethanol is the hydroxy analogue of WR-1065, a metabolite of Amifostine. Amifostine is an organic thiophosphate that has the ability to protect a broad range of tissues from cytotoxicity (e.g. from chemotherapeutic agents) without inducing an antitumour response. 2-(3-Aminopropylamino)ethanol is also used as an nucleophilic tag in the detection of human butyrylcholinesterase adducts. Uses: Designed for use in research and industrial production. Additional or Alternative Names: Ethanol, 2-[(3-aminopropyl)amino]-;1,3-DIAMINO-N-(2-HYDROXYETHYL)-PROPANE;N-(2-Hydroxyethyl)-1,3-Propanediamine. Product Category: Amino Alcohols. Appearance: Clear, colorless liquid. CAS No. 4461-39-6. Molecular formula: C5H14N2O. Mole weight: 118.18. Density: 1.0074. Product ID: ACM4461396. Alfa Chemistry ISO 9001:2015 Certified.
2-(Tritylthio)ethanamine
2-(Tritylthio)ethanamine is an intermediate in the synthesis of Amifostine Thiol Dihydrochloride-d6 (A576823), which is a metabolite of amifostine. Group: Biochemicals. Grades: Highly Purified. CAS No. 1095-85-8. Pack Sizes: 50mg, 250mg. Molecular Formula: C21H21NS. US Biological Life Sciences.
Worldwide
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