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| Product | Description | |
|---|---|---|
| Amifostine thiol | Amifostine Thiol is a metabolite of Amifostine. Amifostine thiol activates p53 through a JNK-dependent signaling pathway. Synonyms: 2-[(3-Aminopropyl)amino]-ethanethiol; N-(2-Mercaptoethyl)-1,3-diaminopropane; NSC 647527; WR 1065. Grades: 95%. CAS No. 31098-42-7. Molecular formula: C5H14N2S. Mole weight: 134.25. |  |
| Amifostine thiol | United States Pharmacopeia (USP) Reference Standard. Group: Pharmacopeia & metrological institutes standards. |  |
| Amifostine Thiol Dihydrochloride | A metabolite of Amifostine. Group: Biochemicals. Alternative Names: 2-[ (3-Aminopropyl) amino]ethanethiol Hydrochloride; WR 1065. Grades: Highly Purified. CAS No. 14653-77-1. Pack Sizes: 10mg. US Biological Life Sciences. |  Worldwide |
| Amifostine Thiol Dihydrochloride-d4 | Amifostine Thiol Dihydrochloride-d4 is the isotope labelled analog of Amifostine Thiol Dihydrochloride, which is a metabolite of amifostine. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 1mg, 10mg. Molecular Formula: C5H12D4Cl2N2S, Molecular Weight: 211.19. US Biological Life Sciences. | Worldwide |
| 2- (3- ( (2- (Tritylthio) ethyl) amino) propyl) isoindoline-1, 3-dione-d6 | 2- (3- ( (2- (Tritylthio) ethyl) amino) propyl) isoindoline-1, 3-dione-d6 is an intermediate in the synthesis of Amifostine Thiol Dihydrochloride-d6 (A576823), which is a metabolite of amifostine. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 2.5mg, 5mg. Molecular Formula: C32H24D6N2O2S. US Biological Life Sciences. | Worldwide |
| 2-(Tritylthio)ethanamine | 2-(Tritylthio)ethanamine is an intermediate in the synthesis of Amifostine Thiol Dihydrochloride-d6 (A576823), which is a metabolite of amifostine. Group: Biochemicals. Grades: Highly Purified. CAS No. 1095-85-8. Pack Sizes: 50mg, 250mg. Molecular Formula: C21H21NS. US Biological Life Sciences. | Worldwide |
| Amifostine | Amifostine is a phosphorylated aminosulfhydryl compound. After dephosphorylation of amifostine by alkaline phosphatase to an active free sulfhydryl (thiol) metabolite, the thiol metabolite binds to and detoxifies cytotoxic platinum-containing metabolites of cisplatin and scavenges free radicals induced by cisplatin and ionizing radiation. The elevated activity of this agent in normal tissues results from both the relative abundance of alkaline phosphatase in normal tissues and the greater vascularity of normal tissues compared to tumor tissues. Uses: Radiation-protective agents. Synonyms: Ethyol; WR2721; WR 2721; WR-2721. Grades: >98%. CAS No. 20537-88-6. Molecular formula: C5H15N2O3PS. Mole weight: 214.22. | |
| WR 1065 | WR 1065 is a metabolite of Amifostine, and a cell-permeable reactive oxygen species scavenger that activates p53 through a JNK-dependent signaling pathway. WR 1065 activates p21waf-1 and MDM2 and inhibits DNA topoisomerase II&alpha. WR 1065 can induce cell cycle arrest and exert cytoprotective activity towards normal cells but not cancer cells in vivo. Synonyms: NSC345308; NSC 345308; NSC-345308; WR1065 Dihydrochloride; WR 1065 Dihydrochloride; WR-1065 Dihydrochloride; 2-[(3-Aminopropyl)amino]ethanethiol dihydrochloride; WR 1065 hydrochloride; Amifostine Thiol Dihydrochloride; WR-1065 dihydrochloride. CAS No. 14653-77-1. Molecular formula: C5H14N2S.2HCl. Mole weight: 207.16. | |
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