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| Product | Description | |
|---|---|---|
| Amiloride | Amiloride (MK-870) is an inhibitor of both epithelial sodium channel ( ENaC [1] ) and urokinase-type plasminogen activator receptor ( uTPA [2] ). Amiloride is a blocker of polycystin-2 (PC2; TRPP2 [3] ) channel. Uses: Scientific research. Group: Signaling pathways. Alternative Names: MK-870. CAS No. 2609-46-3. Pack Sizes: 10 mM * 1 mL; 100 mg. Product ID: HY-B0285. |  |
| Amiloride-15N3 (HCl) | Amiloride-15N3 (HCl). Uses: For analytical and research use. Group: Impurity standards. Alternative Names: Amiloride-15N3 (HCl). Molecular Formula: C6H8ClN415N3O·HCl. Mole Weight: 269.07. Catalog: APB03153. |  |
| Amiloride EP Impurity A | Amiloride EP Impurity A. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: methyl 3,5-diamino-6-chloropyrazine-2-carboxylate. CAS No. 1458-01-1. Molecular Formula: C6H7ClN4O2. Mole Weight: 202.60. Catalog: APB1458011. | |
| Amiloride EP Impurity C | Amiloride EP Impurity C. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: 3-amino-N-carbamimidoyl-6-chloro-5-hydroxypyrazine-2-carboxamide. CAS No. 76599-74-1. Molecular Formula: C6H7ClN6O2. Mole Weight: 230.61. Catalog: APB76599741. | |
| Amiloride EP Impurity C (HCl) | Amiloride EP Impurity C (HCl). Uses: For analytical and research use. Group: Impurity standards. Alternative Names: 3-amino-6-chloro-N-(diaminomethylene)-5-hydroxypyrazine-2-carboxamide hydrochloride. Molecular Formula: C6H7ClN6O2·HCl. Mole Weight: 267.07. Catalog: APB03152. | |
| Amiloride HCl | Amiloride HCl is a relatively selective inhibitor of the epithelial sodium channel, used in the management of hypertension and congestive heart failure. Uses: Acid sensing ion channel blockers. Synonyms: Amiloride HCl anhydrous; Amiloride (hydrochloride); Amiloride hydrochloride anhydrous; MK-870 hydrochloride; N-Amidino-3,5-diamino-6-chloropyrazinecarboxamide hydrochloride. Grades: ≥ 98%. (HPLC). CAS No. 2016-88-8. Molecular formula: C6H9Cl2N7O. Mole weight: 266.09. |  |
| Amiloride hydrochloride | Amiloride hydrochloride (MK-870 hydrochloride) is an inhibitor of both epithelial sodium channel ( ENaC [1] ) and urokinase-type plasminogen activator receptor ( uTPA [2] ). Amiloride hydrochloride is a blocker of polycystin-2 (PC2; TRPP2 [3] ) channel. Uses: Scientific research. Group: Signaling pathways. Alternative Names: MK-870 hydrochloride. CAS No. 2016-88-8. Pack Sizes: 10 mM * 1 mL; 100 mg; 500 mg. Product ID: HY-B0285A. | |
| Amiloride Hydrochloride | Sodium channel blocker. Diuretic. Group: Biochemicals. Alternative Names: 3,5-Diamino-N-(aminoiminomethyl)-6-chloro-2-pyrazinecarboxamide Hydrochloride; N-Amidino-3, 5-diamino-6-chloro cyrazinecarboxamide Monohydrochloride; N-Amidino-3,5-diamino-6-chloropyrazinamide Hydrochloride; Amipramidine; Amipramizide; Amiprazide; Colectril; Midamor; Nilurid. Grades: Highly Purified. CAS No. 2016-88-8. Pack Sizes: 1g. US Biological Life Sciences. |  Worldwide |
| Amiloride hydrochloride dihydrate | Amiloride hydrochloride dihydrate. Group: Biochemicals. Alternative Names: 3,5-Diamino-N-(aminoiminomethyl)-6-chloro-2-pyrazinecarboxamide hydrochloride; N-Amidino-3, 5-diamino-6-chloro cyrazinecarboxamide monohydrochloride; N-Amidino-3,5-diamino-6-chloropyrazinamide hydrochloride. Grades: Highly Purified. CAS No. 2016-88-8. Pack Sizes: 500mg, 1g, 2g, 5g, 10g. Molecular Formula: C6H9Cl2N7O. US Biological Life Sciences. | Worldwide |
| Amiloride hydrochloride dihydrate | Amiloride hydrochloride dihydrate (MK-870 hydrochloride dihydrate) is an inhibitor of both epithelial sodium channel ( ENaC [1] ) and urokinase-type plasminogen activator receptor ( uTPA [2] ). Amiloride hydrochloride dihydrate is a blocker of polycystin-2 (PC2; TRPP2 [3] ) channel. Uses: Scientific research. Group: Signaling pathways. Alternative Names: MK-870 hydrochloride dihydrate. CAS No. 17440-83-4. Pack Sizes: 10 mM * 1 mL; 100 mg. Product ID: HY-B0285B. | |
| Amiloride Hydrochloride Dihydrate | Amiloride Hydrochloride Dihydrate. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: 3,5-diamino-N-carbamimidoyl-6-chloropyrazine-2-carboxamide hydrochloride dihydrate. CAS No. 2016-88-8. Molecular Formula: C6H8ClN7O·HCl·2H2O. Mole Weight: 302.13. Catalog: APB2016888. | |
| Amiloride Hydrochloride Dihydrate | Amiloride precludes the alkalinization and in parallel inhibit cellular proliferation. Synonyms: Amiloride HCl dihydrate; MK-870 hydrochloride dihydrate; N-Amidino-3,5-diamino-6-chloropyrazinecarboxamide hydrochloride dihydrate. Grades: >98%. CAS No. 17440-83-4. Molecular formula: C6H13Cl2N7O3. Mole weight: 302.12. | |
| Amiloride (hydrochloride) (Standard) | Amiloride (hydrochloride) (Standard) is the analytical standard of Amiloride (hydrochloride). This product is intended for research and analytical applications. Amiloride hydrochloride (MK-870 hydrochloride) is an inhibitor of both epithelial sodium channel ( ENaC [1] ) and urokinase-type plasminogen activator receptor ( uTPA [2] ). Amiloride hydrochloride is a blocker of polycystin-2 (PC2; TRPP2 [3] ) channel. Uses: Scientific research. Group: Signaling pathways. Alternative Names: MK-870 hydrochloride (Standard). CAS No. 2016-88-8. Pack Sizes: 5 mg; 10 mg; 25 mg. Product ID: HY-B0285AR. | |
| Amiloride Related Compound A | Amiloride Related Compound. Synonyms: Methyl 3,5-Diamino-6-chloropyrazine-2-carboxylate. Grades: > 95%. CAS No. 1458-01-1. Molecular formula: C6H7ClN4O2. Mole weight: 202.6. | |
| 5-(N-Ethyl-N-isopropyl) amiloride | 5-(N-Ethyl-N-isopropyl) amiloride. Group: Biochemicals. Alternative Names: 3-Amino-N-(aminoiminomethyl)-6-chloro-5-[ethyl(1-methylethyl)amino]-2-pyrazinecarboxamide. Grades: Highly Purified. CAS No. 1154-25-2. Pack Sizes: 10mg, 25mg, 50mg, 100mg, 250mg. Molecular Formula: C11H18ClN7O. US Biological Life Sciences. | Worldwide |
| 5-(N-Ethyl-N-isopropyl) Amiloride (EIPA) | Selective Na+/H+ antiporter inhibitor. Selectively enhances the excretion of sodium ions without causing an increase in excretion of potassium ions. Group: Biochemicals. Alternative Names: EIPA. Grades: Highly Purified. Pack Sizes: 25mg. US Biological Life Sciences. | Worldwide |
| 5-(N,N-dimethyl)-amiloride hydrochloride | Cas No. 2235-97-4. | |
| 5-(N,N-Hexamethylene)-amiloride | 5-(N,N-Hexamethylene)-amiloride derives from an amiloride and is a potent Na+/H+ exchanger inhibitor, which decreases the intracellular pH (pHi) and induces apoptosis in leukemic cells. It is also an inhibitor of the HIV-1 Vpu virus ion channel and inhibits mouse hepatitis virus (MHV) replication and human coronavirus 229E (HCoV229E) replication in cultured L929 cells with EC50s of 3.91 μM and 1.34 μM, respectively. Synonyms: Hexamethylene amiloride; HMA. Grades: 0.98. CAS No. 1428-95-1. Molecular formula: C12H18ClN7O. Mole weight: 311.77. | |
| 5-(N,N-Hexamethylene)-amiloride | 5-(N,N-Hexamethylene)-amiloride (Hexamethylene amiloride) derives from an amiloride and is a potent Na + /H + exchanger inhibitor, which decreases the intracellular pH (pH i ) and induces apoptosis in leukemic cells. 5-(N,N-Hexamethylene)-amiloride (Hexamethylene amiloride) is also an inhibitor of the HIV-1 Vpu virus ion channel and inhibits mouse hepatitis virus (MHV) replication and human coronavirus 229E (HCoV229E) replication in cultured L929 cells with EC 50 s of 3.91 μM and 1.34 μM, respectively [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: Hexamethylene amiloride; HMA. CAS No. 1428-95-1. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-128067. | |
| EIPA (Ethylisopropyl Amiloride, 3-Amino-N-(aminoiminomethyl)-6-chloro-5-[ethyl(1-methylethyl)amino]-2-pyrazinecarboxamide) | EIPA (Ethylisopropyl Amiloride, 3-Amino-N-(aminoiminomethyl)-6-chloro-5-[ethyl(1-methylethyl)amino]-2-pyrazinecarboxamide). Group: Biochemicals. Grades: Highly Purified. CAS No. 1154-25-2. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| 2-Methoxyethyl 3-amino-6-chloro-5- (ethyl (isopropyl) amino) pyrazine-2-carboxylate | 2-Methoxyethyl 3-amino-6-chloro-5- (ethyl (isopropyl) amino) pyrazine-2-carboxylate is an impurity in the synthesis of 5-(N-Ethyl-N-isopropyl) Amiloride which is a selective Na+/H+ antiporter inhibitor. Selectively enhances the excretion of sodium ions without causing an increase in excretion of potassium ions. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 25mg, 50mg. Molecular Formula: C13H21ClN4O3. US Biological Life Sciences. | Worldwide |
| 3,5-Diamino-6-chloropyrazine-2-carboxylic acid methyl ester | 3,5-Diamino-6-chloropyrazine-2-carboxylic acid methyl ester. Group: Biochemicals. Alternative Names: Methyl 3, 5-Diamino-6-chloropyrazinecarboxyl ate; 3,5-Diamino-6-chloro-2-pyrazinecarboxylic Acid Methyl Ester; USP Amiloride Related Compound A. Grades: Highly Purified. CAS No. 1458-01-1. Pack Sizes: 25g, 50g, 100g, 250g. Molecular Formula: C?H?ClN?O?, Molecular Weight: 202.6. US Biological Life Sciences. | Worldwide |
| 3-Amino-5,6-dichloro-2-pyrazinecarboxylic Acid Methyl Ester | 3-Amino-5,6-dichloro-2-pyrazinecarboxylic Acid Methyl Ester, is used for the preparation of 2-Amidino analogs of glycine-Amiloride (A578700) conjugates, acting as inhibitors of the protease urokinase plasminogen activator (uPA), a promising anticancer targets. Group: Biochemicals. Grades: Highly Purified. CAS No. 1458-18-0. Pack Sizes: 1g, 2.5g. Molecular Formula: C6H5Cl2N3O2. US Biological Life Sciences. | Worldwide |
| 3-Amino-6-chloro-5-[ethyl(1-methylethyl)amino]-2-pyrazinecarboxylic Acid Methyl Ester | 3-Amino-6-chloro-5-[ethyl(1-methylethyl)amino]-2-pyrazinecarboxylic Acid Methyl Ester is an intermediate in the synthesis of 5-(N-Ethyl-N-isopropyl) Amiloride which is a selective Na+/H+ antiporter inhibitor. Selectively enhances the excretion of sodium ions without causing an increase in excretion of potassium ions. Group: Biochemicals. Grades: Highly Purified. CAS No. 14232-37-2. Pack Sizes: 10mg, 25mg. Molecular Formula: C11H17ClN4O2. US Biological Life Sciences. | Worldwide |
| ASIC Channel Modulator II, GMQ (2-guanidine-4-methylquinazoline, Acid-sensing Ion Channel Modulator II) | A positively charged guanidium-containing quinazoline that modulates ASIC function by blocking acid-induced maximal peak current as well as by altering ASICs pH dependence for activation and inactivation, enabling a partial, but sustained ASIC3 activation around neutral pH (4.4% of pH 5-induced peak current with 1mM GMQ at pH 7.4), which is inhibitable by Amiloride. Intraplantar paw injection (10ul 100uM) is reported to elicit a pain response in asic3+/+, but not asic3-/-, mice in vivo. GMQ targeting area appears to overlap with Amiloride binding site in the pore region, but is distinct from ASIC calcium binding site. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 25mg. Molecular Formula: C??H??N?. US Biological Life Sciences. | Worldwide |
| Benzamil hydrochloride | Benzamil hydrochloride (Benzylamiloride hydrochloride), an Amiloride analogue, is a Na + /Ca 2+ exchanger (NCX) inhibitor ( IC 50 ~100 nM). Benzamil hydrochloride also is a non-selective Deg/epithelial sodium channels (ENaC) blocker, and can potentiate myogenic vasoconstriction. Benzamil hydrochloride inhibits TRPP3-mediated Ca 2+ -activated currents, with an IC 50 of 1.1 μM [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: Benzylamiloride hydrochloride. CAS No. 161804-20-2. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-B1546A. | |
| Benzamil hydrochloride | Benzamil hydrochloride is a Na+/Ca2+ exhanger (NCX) inhibitor (IC50 ~ 100 nM) and an epithelial sodium channel (ENaC) blocker. Benzamil is an analogue of amiloride, and it is potentially used for the treatment of cystic fibrosis. Uses: Potential treatment of cystic fibrosis. Synonyms: N-(Benzylamidino)-3,5-diamino-6-chloropyrazinecarboxamide hydrochloride. Grades: ≥98% by HPLC. CAS No. 161804-20-2. Molecular formula: C13H14ClN7O.HCl. Mole weight: 356.21. | |
| Phenamil | Phenamil, a second generation analog of amiloride (hydrochloride), inhibits TRPP3-mediated currents (IC50 = 0.14 μM) and also inhibits epithelial Na+ channels (Kd = 0.4 nM for a high affinity site on the epithelial Na+ channel). Synonyms: 2-Pyrazinecarboxamide, 3,5-diamino-6-chloro-N-[imino(phenylamino)methyl]-; 3,5-Diamino-6-chloro-N-[imino(phenylamino)methyl]-2-pyrazinecarboxamide; Pyrazinecarboxamide, 3,5-diamino-6-chloro-N-(phenylamidino)-; Pyrazinecarboxamide, 3,5-diamino-6-chloro-N-[imino(phenylamino)methyl]-; Phenylamil; 3,5-diamino-6-chloro-N-(N-phenylcarbamimidoyl)pyrazine-2-carboxamide; 3, 5-Diamino-6-chloro-N-[imino (phenylamino) methyl]pyrazinecarboxamide. Grades: ≥95%. CAS No. 2038-35-9. Molecular formula: C12H12ClN7O. Mole weight: 305.72. | |
| Phenamil (3,5-Diamino-6-chloro-N-[imino(pheny lamino) methyl] pyrazinecarboxamide methanesulfonate salt) | TRPP3 channel inhibitor (IC50=0.14um). Also inhibits epithelial Na+ channels (Kd=0.4nm for a high affinity site on the epithelial Na+ channel). Derivative of amiloride. Group: Biochemicals. Grades: Highly Purified. CAS No. 1161-94-0. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| Phenamil methanesulfonate | Phenamil methanesulfonate, an analog of Amiloride (HY-B0285), is a more potent and less reversible epithelial sodium channel (ENaC) blocker with an IC 50 of 400 nM [2]. Phenamil methanesulfonate is also a competive inhibitor of TRPP3 and inhibits TRPP3-mediated Ca 2+ transport with an IC 50 of 140 nM in a Ca 2+ uptake assay [1]. Phenamil methanesulfonate is an intriguing small molecule to promote bone repair by strongly activating BMP signaling pathway [4]. Phenamil methanesulfonate is used for the research of cystic fibrosis lung disease [5]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1161-94-0. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg. Product ID: HY-108464A. | |
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