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A potent, selective and systemically active positive allosteric modulator for mGlu7 receptor (EC50 = 64-290nM). One of the most frequently used agent for assessing the functional roles of mGlu7 receptors in a variety of brain functions (i.e. sleep pattern, learning and memory, and locomotion) and disorders (i.e. depression, anxiety, and Parkinsons disease). Induces internalization of mGlu7 receptors. Also acts onnMDA, AMPA, 5-HT receptors and norepinephrine transporter. Group: Biochemicals. Grades: Highly Purified. CAS No. 97075-46-2. Pack Sizes: 10mg. US Biological Life Sciences.
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AMN082 free base
AMN082 free base, a selective, orally active, and brain penetrant mGluR7 agonist, directly activates receptor signaling via an allosteric site in the transmembrane domain. AMN082 free base potently inhibits cAMP accumulation and stimulates GTPγS binding ( EC 50 values, 64-290 nM) at transfected mammalian cells expressing mGluR7. AMN082 free base shows selectivity over other mGluR subtypes and selected ionotropic glutamate receptors. Antidepressant effects [1] [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 83027-13-8. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-103565A.
AMN 082 dihydrochloride
The hydrochloride salt form of AMN 082 has been found to be a mGlu7 agonist. Synonyms: AMN 082; AMN-082; AMN082; N,N'-Bis(diphenylmethyl)-1,2-ethanediamine dihydrochloride. Grades: ≥99% by HPLC. CAS No. 97075-46-2. Molecular formula: C28H28N2.2HCl. Mole weight: 465.45.
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