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| Product | Description | |
|---|---|---|
| Amonafide | Amonafide is a DNA intercalator and topoisomerase II inhibitor in clinical development for the treatment of neoplastic diseases. Antitumor agent. Group: Biochemicals. Alternative Names: 5-Amino-2-[2-(dimethylamino)ethyl]-1H-benz[de]isoquinoline-1,3(2H)-dione; FA 142; M-FA 142; MADE-FA 142; NCI 308847; NSC 308847; Nafidimide. Grades: Highly Purified. CAS No. 69408-81-7. Pack Sizes: 10mg. US Biological Life Sciences. |  Worldwide |
| Amonafide | Amonafide is an imide derivative of naphthalic acid. Amonafide intercalates into DNA and inhibits topoisomerase II, resulting in protein-associated strand breaks and impaired DNA and RNA synthesis. Uses: Antineoplastic agents. Synonyms: Nafidimide; Quinamed; Xanafide. Grade: 0.98. CAS No. 69408-81-7. Molecular formula: C16H17N3O2. Mole weight: 283.33. |  |
| Amonafide | Amonafide is a topoisomerase II inhibitor and DNA intercalator that induces apoptotic signaling by blocking the binding of Topo II to DNA. Uses: Scientific research. Group: Signaling pathways. Alternative Names: AS1413. CAS No. 69408-81-7. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-10982. |  |
| Amonafide L-malate | Amonafide L-malate is the malate salt of amonafide, an imide derivative of naphthalic acid, with potential antineoplastic activity. Amonafide intercalates into DNA and inhibits topoisomerase II, resulting in DNA double-strand breaks (DSB) and inhibition of DNA replication and RNA synthesis. Synonyms: AS1413; AS 1413; AS-1413; XLS-001; XLS001; XLS001; Xanafide. CAS No. 618863-60-8. Molecular formula: C20H24N4O6. Mole weight: 416.43. | |
| Amonafide N-oxide | Amonafide N-oxide. Group: Biochemicals. Alternative Names: 5-Amino-2-[2- (dimethyloxidoamino) ethyl]-1H-benz[de]isoquinoline-1, 3 (2H) -dione; 5-Amino-2-[2-(dimethylamino)ethyl]-1H-benz[de]isoquinoline-1,3(2H)-dione N-oxide. Grades: Highly Purified. CAS No. 112726-97-3. Pack Sizes: 1mg, 2mg, 5mg, 10mg. Molecular Formula: C16H17N3O3. US Biological Life Sciences. | Worldwide |
| Amonafide N-oxide | Amonafide N-oxide. Uses: Designed for use in research and industrial production. Additional or Alternative Names: 5-Amino-2-[2-(dimethyloxidoamino)ethyl]-1H-benz[de]isoquinoline-1,3(2H)-dione; 5-Amino-2-[2-(dimethylamino)ethyl]-1H-benz[de]isoquinoline-1,3(2H)-dione N-Oxide. Product Category: Heterocyclic Organic Compound. CAS No. 112726-97-3. Molecular formula: C16H17N3O3. Mole weight: 299.32. Product ID: ACM112726973. Alfa Chemistry ISO 9001:2015 Certified. |  |
| N-Acetyl Amonafide | A metabolite of Amonafide. Group: Biochemicals. Alternative Names: N-[2-[2-(Dimethylamino)ethyl]-2,3-dihydro-1,3-dioxo-1H-benz[de]isoquinolin-5-yl]acetamide; MADE-FA 4512; N-Acetylamonafide. Grades: Highly Purified. CAS No. 69409-02-5. Pack Sizes: 2.5mg. US Biological Life Sciences. | Worldwide |
| N'-Desmethyl amonafide | N'-Desmethyl amonafide. Group: Biochemicals. Alternative Names: 5-Amino-2-[2-(methylamino)ethyl]-1H-benz[de]isoquinoline-1,3(2H)-dione. Grades: Highly Purified. CAS No. 114991-16-1. Pack Sizes: 1mg, 2mg, 5mg, 10mg, 25mg. Molecular Formula: C15H15N3O2. US Biological Life Sciences. | Worldwide |
| Ethonafide | Ethonafide is an anthracene-containing derivative of amonafide that belongs to the azonafide series of anticancer agents. The lack of cross-resistance in multidrug-resistant cancer cell lines and the absence of a quinone and hydroquinone moiety make ethonafide a potentially less cardiotoxic replacement for existing anthracene-containing anticancer agents. Ethonafide was cytotoxic against three human prostate cancer cell lines at nanomolar concentrations. Ethonafide was found to be better tolerated and more effective at inhibiting tumor growth compared with mitoxantrone in a human xenograft tumor regression mouse model. Mechanistically, we found that ethonafide inhibited topoisomerase II activity by stabilizing the enzyme-DNA complex, involving both topoisomerase IIalpha and -beta. In addition, ethonafide induced a potent G(2) cell cycle arrest in the DU 145 human prostate cancer cell line. By creating stable cell lines with decreased expression of topoisomerase IIalpha or -beta, we found that a decrease in topoisomerase IIalpha protein expression renders the cell line resistant to ethonafide. The decrease in sensitivity to ethonafide was associated with a decrease in DNA damage and an increase in DNA repair as measured by the neutral comet assay. These data demonstrate that ethonafide is a topoisomerase II poison and that it is topoisomerase IIalpha-specific in the DU 145 human prostate cancer cell line. Uses: Topoisomerase ii | |
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