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| Product | Description | |
|---|---|---|
| ANA-12 | ?98% (HPLC). Group: Fluorescence/luminescence spectroscopy. |  |
| ANA-12 | ANA-12 is a potent and selective TrkB antagonist with IC 50 s of 45.6 nM and 41.1 μM for the high and low affinity sites, respectively. Uses: Scientific research. Group: Signaling pathways. CAS No. 219766-25-3. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg. Product ID: HY-12497. |  |
| ANA-12 | ANA-12 is a selective TrkB antagonist. ANA-12 showed direct and selective binding to TrkB and inhibited processes downstream of TrkB without altering TrkA and TrkC functions. Synonyms: ANA12; ANA 12; ANA-12. Grade: >98%. CAS No. 219766-25-3. Molecular formula: C22H21N3O3S. Mole weight: 407.49. |  |
| TrkB Antagonist, ANA-12 (N- (2- ( (2-oxoazepan-3-yl) carbamoyl) phenyl) benzo[b]thiophene-2-carboxamide) | A cell-permeable thiophene carboxymide derived compound that acts as a direct and selective antagonist of TrkB receptor. Binds to the high affinity site on the extracellular domain of TrkB in a dose-dependent manner (Kd = 10nM) exhibiting much reduced binding to the low affinity site (Kd =12uM) indicating that it does not compete with BDNF for the same binding site. Does not affect TrkA or TrkC receptors. Shown to permeate the blood-brain barrier, however, its antagonistic effects are not uniform throughout the brain. Does not affect the survivability of neurons. Reduces anxiety and depression related behavior in mice. Group: Biochemicals. Grades: Highly Purified. CAS No. 219766-25-3. Pack Sizes: 25mg. Molecular Formula: C??H??N?O?S. US Biological Life Sciences. |  Worldwide |
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