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| Product | Description | |
|---|---|---|
| Antagonist G | Antagonist G. Group: Biochemicals. Grades: Purified. CAS No. 115150-59-9. Pack Sizes: 1mg. US Biological Life Sciences. |  Worldwide |
| Antagonist G | Antagonist G is a substance P analog, which is a broad spectrum neuropeptide growth factor antagonist and antiproliferative agent. It was developed for the treatment of small cell lung cancer. It could inhibit neuropeptide-dependent and -independent proliferation of small cell lung cancer in vitro. It also inhibits growth of SCLC xenografts in mice in vivo. It blocks Swiss 3T3 cell growth induced by vasopressin, gastrin-releasing peptide and bradykinin. It activates JNK and stimulates apoptosis. It is an anticancer agent and is resistant to degradation by peptidases. Synonyms: [Arg6,D-Trp7,9,N-MePhe8]-Substance P(6-11). Grades: 98%. CAS No. 115150-59-9. Molecular formula: C49H66N12O6S. Mole weight: 951.20. |  |
| 14-3-3 Antagonist I, 2-5 ( (S) -2- (2- (4-Azidobenzamido) acetamido) -3- ( (4-hydroxyphenethyl) amino) -3-oxopropyl-dihydrogen Phosphate) | A cell-permeable dipeptidyl-phosphoserine compound that effectively disrupts 14-3-3 interaction with its ligands (IC50=2.6uM against TMR-GG-RLSHpSSLPG binding to human 14-3-3 sigma), including Raf-1 and p53. Shown to induce caspase-3 activation and apoptotic cell death in human lung adenocarcinoma A549 cultures (100uM) in a time-dependent manner. Group: Biochemicals. Grades: Purified. Pack Sizes: 5mg. Molecular Formula: C??H??N?O?P, Molecular Weight: 506.4. US Biological Life Sciences. | Worldwide |
| 2,3 cis-Piperidine Dicarboxylic Acid (Ionotropic Glutamate Receptor Antagonist, PDA, cis PDA, cis-Piperidine-2,3-dicarboxylic Acid) | A non-specific antagonist of NMDA, AMPA and kainate ionotropic receptors and a partial agonist for NMDA receptors. Used in blocking general excitatory synaptic transmissions. Group: Biochemicals. Grades: Highly Purified. CAS No. 46026-75-9. Pack Sizes: 50mg. US Biological Life Sciences. | Worldwide |
| 5-HT2 antagonist 1 | A potent antagonist of 5-HT2 receptor. Synonyms: Pyrrolo[3,2-c]azepin-4(1H)-one, 5-[3-[4-(4-fluorophenyl)-1-piperazinyl]propyl]-5,6,7,8-tetrahydro-8-hydroxy-1-methyl-. CAS No. 191592-09-3. Molecular formula: C22H29FN4O2. Mole weight: 400.49. | |
| 5-HT3 antagonist 1 | A potent and selective antagonist of serotonin 3 (5-HT3) receptor. Synonyms: 1H-1,4-Diazepine, 1H-indazole-3-carboxamide deriv. CAS No. 129294-09-3. Molecular formula: C22H27N5O. Mole weight: 377.48. | |
| 5-HT3 antagonist 5 | 5-HT3 antagonist 5 is a 5-HT3 receptor antagonist with anti-depressant activity. Synonyms: N-(4-methoxyphenyl)-2-quinoxalinecarboxamide. CAS No. 901599-43-7. Molecular formula: C16H13N3O2. Mole weight: 279.29. | |
| 5-HT3 antagonist 5 | 5-HT3 antagonist 5 is a quinoxalin-2-carboxamide compound, a 5-HT 3 receptor antagonist. 5-HT3 antagonist 5 exerts antagonism on 5-HT 3 agonist and 2-methyl-5-HT , and shows anti-depressant effect in mice [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 901599-43-7. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-148038. |  |
| 5-HT6 antagonist 29 | A brain penetrant 5-HT6 receptor antagonist (pKi value 8.6). Synonyms: 5-HT6 antagonist 29; 497963-70-9; 3-(4-chlorophenyl)sulfonyl-1-methyl-7-piperazin-1-ylindole; hydrochloride; PD016667; E98892; 3-(4-chlorophenylsulfonyl)-1-methyl-7-(piperazin-1-yl)-1H-indole hydrochloride. Grades: 99%. CAS No. 497963-70-9. Molecular formula: C19H20ClN3O2S.HCl. Mole weight: 426.36. | |
| A2AR antagonist 1 | A2AR antagonist 1 is a potent A2AR (Adenosine A2A Receptor) antagonist with Ki values of 4 nM and 264 nM for A2AR and A1R, respectively. Synonyms: 1-[(2-fluorophenyl)methyl]-4-(furan-2-yl)pyrazolo[3,4-d]pyrimidin-6-amine. Grades: ≥95%. CAS No. 443103-97-7. Molecular formula: C16H12FN5O. Mole weight: 309.30. | |
| A2A receptor antagonist 1 | A2A receptor antagonist 1 (CPI-444 analog) is an antagonist of both adenosine A 2A receptor and A 1 receptor with K i values of 4 and 264 nM, respectively [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: CPI-444 analog. CAS No. 443103-97-7. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-102024. | |
| A2B receptor antagonist 1 | A potent antagonist of A2B adenosine receptor. Synonyms: 1H-Purine-2,6-dione, 3,9-dihydro-8-[1-(phenylmethyl)-1H-pyrazol-4-yl]-1,3-dipropyl-. CAS No. 531506-36-2. Molecular formula: C21H24N6O2. Mole weight: 392.45. | |
| A317491 ((S)-5-((3-phenoxybenzyl)(1,2,3,4-tetrahydronaphthalen-1-yl)carbamoyl)benzene-1,2,4-tricarboxylic Acid, P2X3 Purinergic Receptors Antagonist, A317491, P2X2/3 Purinergic Receptors Antagonist, A317491, A 317491) | A potent, selective, and competitive non-nucleotide antagonist of P2X3 and P2X2/3 receptors that blocks receptor-mediated Ca2+ flux (Ki = 22 and 92nM for rat P2X3 and P2X2/3 receptor and 22 and 9nM for human P2X3 and P2X2/3 receptor, respectively). Its R-enantiomer has significantly reduced activity at these receptors. Exhibits high selectivity over other purinergic receptors. Shown to reduce thermal and mechanical hyperalgesia in rat models (ED50 = 10-15uM/kg, s.c). Its anti-nociceptive effects have a rapid on-set and persist for up to 5 hours after sub-cutaneous administration. Also shown to block dorsal root ganglion currents in a dose-dependent manner (IC50 = 15nM). Group: Biochemicals. Grades: Highly Purified. CAS No. 475205-49-3. Pack Sizes: 5mg. Molecular Formula: C??H??NO? xH2O xNa. US Biological Life Sciences. | Worldwide |
| Adenosine A1 Receptor Antagonist I, DPCPX (8-Cyclopentyl-1,3-dipropylxanthine, CPX, PD-116,948) | A blood-brain barrier permeable xanthine derivative that acts as a highly selective antagonist of Adenosine A1 receptor (A1R; Ki = 3.9nM, 130nM, 1.0uM, 4.0uM for human A1, A2A, A2B, and A3 respectively). Exhibits about 1,000-fold higher affinity and a 30-fold greater selectivity for A1R when compared to theophylline. Shown to competitively antagonize the inhibition of adenylate cyclase activity via A1 adenosine receptors in rat fat cells and the stimulation of adenylate cyclase via A2 adenosine receptors in human platelets. Exhibits hypertensive properties. Group: Biochemicals. Grades: Highly Purified. CAS No. 102146-07-6. Pack Sizes: 25mg. Molecular Formula: C??H??N?O?, Primary Target: A1. US Biological Life Sciences. | Worldwide |
| Adenosine A2A/A1 Receptor Antagonist (2-Amino-8-(2-morpholinoethoxy)-4-phenyl-5H-indeno[1,2-d]-pyrimidin-5-one, diHCl) | A blood-brain barrier-permeant indenopyrimidinone that acts as a dual A1/A2A antagonist (Ki = 48.2 and 6.5nM, respectively, against agonist-induced cAMP response in A1- or A2A-expressing CHO-K1 cells) and effectively reverses D2 antagonist haloperidol- (1mg/kg; s.c.) induced catalepsy in both rats and mice (ED50 = 0.3 and <0.1mg/kg, respectively) in vivo by simultaneously reversing A1-mediated inhibition of DA (Dopamine) release and A2A-dependent inhibition of D2 receptor response to DA. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| Adenosine A2A Receptor Antagonist II, SCH-58261 (2-(furan-2-yl)-7-phenethyl-7H-pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidin-5-amine, SCH58261, SCH 58261) | A highly potent and selective antagonist of adenosine A2A receptor (Ki = 600pM). Does not affect the activity of other adenosine receptors in any significant manner (Ki = 287nM; 5uM, and > 10uM for A1, A2B, and A3 receptors, respectively). Displays neuroprotective effects in cerebral ischaemia in rats, and shown to counteract Parkinsonian-like muscle rigidity in rats. CAS Number:160098-96-4. Group: Biochemicals. Grades: Highly Purified. CAS No. 160098-96-4. Pack Sizes: 10mg. Molecular Formula: C??H??N?O, Primary Target: A2A Receptor. US Biological Life Sciences. | Worldwide |
| Adenosine A3 Receptor Antagonist, MRS 1523 (3-propyl-6-ethyl-5[(ethylthio)carbonyl]-2-phenyl-4-propyl-3-pyridine-carboxylate, MRS 1523, MRS-1523) | A pyridine derivative that acts as a highly selective antagonist of A3 receptor with excellent potency in both humans and rodents (Ki = 18.9nM for human A3R, and 113nM for rat A3R). Exhibits only a trivial antagonistic activity towards A1 and A2A receptors (Ki = 15.6uM and 2.05uM for rat A1R and A2AR, respectively). Abolishes the agonistic effects of Cl-IB-MECA on A3R-mediated proliferation of primary human coronary smooth muscle cells. Also, reported to block NECA-induced bronchoconstriction in an allergic murine model. Group: Biochemicals. Grades: Highly Purified. CAS No. 212329-37-8. Pack Sizes: 5mg. Molecular Formula: C??H??NO?S. US Biological Life Sciences. | Worldwide |
| Adenosine antagonist-1 | Adenosine antagonist-1 is an adenosine A3 receptor ( AA3R ) antagonist. Uses: Scientific research. Group: Signaling pathways. CAS No. 431040-19-6. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-100274. | |
| Adenosine receptor antagonist 2 | Adenosine receptor antagonist 2 is an orally active A2a/A2b adenosine receptor antagonist with IC 50 s of 1 nM and 3 nM, respectively. Adenosine receptor antagonist 2 has anti-tumor activity [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2703054-47-9. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-144064. | |
| Adenosine receptor antagonist 3 | Adenosine receptor antagonist 3 is a potent antagonist of adenosine receptor. Adenosine receptor antagonist 3 has the potential for the research of cancer disease (extracted from patent WO2019233994A1, compound 1) [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2400864-80-2. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-144419. | |
| AF353 (P2X3 Purinergic Receptor Antagonist, AF353, P2X2/3 Purinergic Receptor Antagonist, AF353) | A novel, potent, orally bioavailable antagonist of P2X3/P2X2/3 receptors (pIC50 = 8 in human and rat; pIC50 = 7.3 for human P2X2/3 receptor). Shown to be highly brain penetrant with a brain to plasma ratio of 6. Blocks agonist-evoked intracellular Ca2+ flux and inward currents in nanomolar range (10nM to 1uM) in cell lines recombinantly expressing human P2X3 and P2X2/3 receptors. Exhibits desirable pharmacokinetic properties (t1/2 = 1.63 h and Tmax = 30 min). Group: Biochemicals. Grades: Highly Purified. CAS No. 927887-18-1. Pack Sizes: 5mg. Molecular Formula: C??H??ClIN?O?. US Biological Life Sciences. | Worldwide |
| AF-DX 116 (Muscarinic Receptor (mAChR) M2 Antagonist, AF-DX 116, Otenzepad, AF-DX116, AF-DX-116, AFDX116) | Selective presynaptic muscarinic receptor M2 antagonist with cardioselectivity. Exhibits antiarrhythmic effects in vivo, also shown to reverse the memory impairment effect of insulin in a mouse model. Group: Biochemicals. Grades: Highly Purified. CAS No. 102394-31-0. Pack Sizes: 10mg. Molecular Formula: C??H??N?O?. US Biological Life Sciences. | Worldwide |
| AHR Antagonist 5 | AHR Antagonist 5, an effective and orally active aromatic hydrocarbon receptor (AHR) antagonist with IC50 of less than 0.5 μM. It can significantly inhibit tumor growth in combination with the checkpoint inhibitor anti-PD-1. Synonyms: BCP33104; HY-136220; CS-0120848; (R)-N-(2-(5-Fluoropyridin-3-Yl)-8-Isopropylpyrazolo[1,5-A][1,3,5]Triazin-4-Yl)-2,3,4,9-Tetrahydro-1H-Carbazol-3-Amine Trihydrochloride. Grades: ≥98% by HPLC. CAS No. 2247953-39-3. Molecular formula: C25H27Cl3FN7. Mole weight: 550.9. | |
| AhR Antagonist III, GNF351 (N-(2-(3H-Indol-3-yl)ethyl)-9-isopropyl-2-(5-methyl-3-pyridyl)-7H-purin-6-amine, N-(2-(1H-Indol-3-yl)ethyl)-9-isopropyl-2-(5-methylpyridin-3-yl)-9H-purin-6-amine) | A cell-permeable purine compound that acts as a high-affinity aryl hydrocarbon receptor (AhR) antagonist (IC50 = 62nM in mouse liver cytosol expressing humanized AhR) and lacks any agonist activity even at higher doses. Reportedly binds with high affinity to the ligand-binding pocket of AhR and blocks the binding of an array of exogenous and endogenous ligands. Shown to non-covalently interact with Ser317, His291, and Ser365 in human and with Ser311, His285, and Ser359 in mouse AhR. Represses AhR transcriptional activity via the dioxin response element (DRE)-dependent and independent mediated responses in human and mouse cells (IC50 = 8.5nM in HepG2 40/6 cells). Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| AMPA/kainate antagonist-1 | AMPA/kainate antagonist-1 is a non-competitive AMPA/kainate antagonist. Synonyms: (r)-(+)-8-methyl-5-(3-methyl-4-nitrophenyl)-8,9-dihydro-7h-1,3-dioxolo[4,5-h][2,3]benzodiazepine. Grades: 98%. CAS No. 732277-05-3. Molecular formula: C18H17N3O4. Mole weight: 339.3. | |
| AMPA/Kainate Antagonist-2 | AMPA/kainate antagonist-2 is a non-competitive AMPA/kainate antagonist. Synonyms: AMPA/kainate antagonist-2; 923271-87-8; AMY40928BCP34146(+)-5-(4-amino-3-methylphenyl)-7-(2-thiazolyl)-8,9-dihydro-7H-1,3-dioxolo-[4,5-h][2,3]benzodiazepine. Grades: 98%. CAS No. 923271-87-8. Molecular formula: C20H18N4O2S. Mole weight: 378.4. | |
| AMPA/kainate antagonist-3 | AMPA/kainate antagonist-3 is a non-competitive AMPA/kainate antagonist. Grades: 98%. CAS No. 732278-52-3. Molecular formula: C21H21N5O2S. Mole weight: 407.5. | |
| Androgen receptor antagonist 1 | Androgen receptor antagonist 1 is an orally available full androgen receptor antagonist (IC50 = 59 nM). It can be used in the synthesis of PROTAC AR degraders, which results in 24% and 47% AR protein degradation in LNCaP cells at 1 μM and 10 μM, respectively. Synonyms: Androgen receptor antagonist 1; 1338812-36-4; CHEMBL1916251; SCHEMBL17941138; SCHEMBL17947423; BDBM50356995; AKOS040732433; MS-27273; HY-130992; CS-0120091; N-[3-(3-chloro-4-cyanophenoxy)-2,2,4,4-tetramethylcyclobutyl]-1-(2-hydroxyethyl)pyrazole-4-carboxamide. Grades: 99%. CAS No. 1338812-36-4. Molecular formula: C21H25ClN4O3. Mole weight: 416.90. | |
| ARE Activator, BTZO-1 (Macrophage Migration Inhibitory Factor Antagonist II, 2-Pyridin-2-yl-4H-1,3-benzothiazin-4-one, MIF Antagonist II) | A cell-permeable benzothiazinone that is shown to interact with MIF homotrimer (=68.6nM and 157nM toward human and rat MIF, respectively, at pH 7.3) via the N-terminal proline in a pH-dependent manner, limiting its inhibitory capability against MIF tautomerase activity (13% inhibition at pH 6.0; [BTZO-1] = 30uM) due to reduced MIF binding at acidic pH. Shown to protect primary rat cardiomyocytes (330nM) from apoptotic death upon serum deprivation or DOX (200nM) treatment via activation of ARE- (antioxidant response element) mediated cytoprotective genes transcription in a MIF-dependent manner. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 10mg. Molecular Formula: C??H?N?OS, Molecular Weight: 240.3. US Biological Life Sciences. | Worldwide |
| (+/-)-Atenolol ( (±) -4- {2-Hydroxy-3- [ (1-methylethyl) amino] propoxy} benzeneacetamide, Beta1-Adrenergic Receptor Blocker, (±)-Atenolol, Beta1-Adrenergic Receptor Antagonist, (±)-Atenolol) | Selective beta-1 adrenergic blocking agent. An anti-hypertensive and anti-arrhythmic agent. Reported to diminish cerebrospinal fluid production. Group: Biochemicals. Grades: Highly Purified. CAS No. 29122-68-7. Pack Sizes: 1g. Molecular Formula: C??H??N?O?. US Biological Life Sciences. | Worldwide |
| β-FXR antagonist 1 | β-FXR antagonist 1 (C 12), an isomer of FXR antagonist 1 (HY-151481) is a FXR antagonist [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2295804-92-9. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-151481A. | |
| Bicuculline, 98+% (GABAA Receptor Antagonist, (+)-Bicuculline) | A potent allosteric antagonist of vertebrate GABAA receptors. Blocks GABAA-induced chloride currents in cultured neurons (IC50 = 740nM). Shown to increase blood pressure in spontaneously hypertensive rats and cause convulsion in experimental animals. Also, increases the amplitude of spontaneous colonic contractions. Group: Biochemicals. Alternative Names: (6R)-6-[(5S)-5,6,7,8-Tetrahydro-6-methyl-1,3-dioxolo[4,5-g]lisoquinolin-5-yl]furo[3,4-e]-1,3-benzodioxol-8(6H)-one; (+)-Bicuculline; d-Bicuculline; NSC 32192. Grades: Highly Purified. CAS No. 485-49-4. Pack Sizes: 100mg, 250mg. Molecular Formula: C??H??NO?, Molecular Weight: 367.35. US Biological Life Sciences. | Worldwide |
| Bicuculline, 99+% (GABAA Receptor Antagonist, (+)-Bicuculline) | A potent allosteric antagonist of vertebrate GABAA receptors. Blocks GABAA-induced chloride currents in cultured neurons (IC50 = 740nM). Shown to increase blood pressure in spontaneously hypertensive rats and cause convulsion in experimental animals. Also, increases the amplitude of spontaneous colonic contractions. Group: Biochemicals. Alternative Names: (6R)-6-[(5S)-5,6,7,8-Tetrahydro-6-methyl-1,3-dioxolo[4,5-g]lisoquinolin-5-yl]furo[3,4-e]-1,3-benzodioxol-8(6H)-one; (+)-Bicuculline; d-Bicuculline; NSC 32192. Grades: Highly Purified. CAS No. 485-49-4. Pack Sizes: 50mg. Molecular Formula: C??H??NO?, Molecular Weight: 367.35. US Biological Life Sciences. | Worldwide |
| Bicuculline (GABAA Receptor Antagonist, (+)-Bicuculline) | Bicuculline (GABAA Receptor Antagonist, (+)-Bicuculline). Group: Biochemicals. Alternative Names: (6R)-6-[(5S)-5,6,7,8-Tetrahydro-6-methyl-1,3-dioxolo[4,5-g]lisoquinolin-5-yl]furo[3,4-e]-1,3-benzodioxol-8(6H)-one; (+)-Bicuculline; d-Bicuculline; NSC 32192. Grades: Plant Grade. CAS No. 485-49-4. Pack Sizes: 20mg. Molecular Formula: C20H17NO6, Molecular Weight: 367.351999999999. US Biological Life Sciences. | Worldwide |
| Calcium Antagonist Library | A unique collection of 143 calcium channel blockers and agonists for high throughput and high content screening; - Targeting different subtypes of calcium channels, such as L-type, T-type, N-type, and receptor-operated calcium channels. - Bioactivity and safety confirmed by pre-clinical research and clinical trials, some of which are FDA approved; - Detailed compound information with structure, target, activity, IC50 value, and biological activity description; - Structurally diverse, medicinally active, and cell permeable; - NMR and HPLC validated to ensure high purity and quality. Uses: Scientific use. Product Category: L7200. Categories: Calcium Antagonist Libraries. |  |
| Calcium Channel antagonist 2 | Calcium Channel antagonist 2 (Compound 154) is a calcium channel antagonist ( IC 50 =5-20 μM). Calcium Channel antagonist 2 can be used in study of calcium channel-mediated diseases such as pain and diabetes [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 874370-15-7. Pack Sizes: 10 mg. Product ID: HY-156663. | |
| Calcium Channel antagonist 3 | Calcium Channel antagonist 3 (compound 397) is an inhibitor of voltage-gated calcium channels with an IC 50 value of 5-20μM [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 687573-14-4. Pack Sizes: 5 mg; 10 mg. Product ID: HY-156664. | |
| Calcium Channel antagonist 4 | Calcium Channel antagonist 4 (compound 189) is an inhibitor of voltage-gated calcium channels with an IC 50 value of 5-20μM [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 687574-49-8. Pack Sizes: 10 mg. Product ID: HY-156669. | |
| Calcium-Sensing Receptor Antagonists I | Calcium-Sensing Receptor Antagonists I is an antagonist of calcium-sensing parathyroid hormone receptors. Synonyms: 2(1H)-Quinazolinone, 1-(1-methylethyl)-4-[4-(1-methylethyl)phenyl]-6-(2-propyn-1-yloxy)-. Grades: >98%. CAS No. 478963-79-0. Molecular formula: C23H24N2O2. Mole weight: 360.45. | |
| Calmodulin Antagonist W-12 (N-(4-aminobutyl)-2-naphthalenesulfonamide hydrochloride) | Antagonist of calmodulin, inhibiting activation of Ca2+/calmodulin-dependent phosphodiesterase (PDE I) and myosin light chain kinase. Group: Biochemicals. Alternative Names: N-(4-aminobutyl)--2-naphthalenesulfonamide hydrochloride. Grades: Molecular Biology Grade. CAS No. 89108-46-3. Pack Sizes: 25mg. US Biological Life Sciences. | Worldwide |
| Calmodulin Antagonist W-13 (N-(4-aminobutyl)-5-chloro-2-naphthalenesulfonamide hydrochloride) | An Ergosterol Biosynthesis inhibitor. Group: Biochemicals. Alternative Names: N-(4-aminobutyl)-5-chloro-2-naphthalenesulfonamide hydrochloride. Grades: Molecular Biology Grade. CAS No. 88519-57-7. Pack Sizes: 5mg, 25mg. US Biological Life Sciences. | Worldwide |
| Calmodulin Antagonist W-5 | Antagonist of calmodulin, inhibiting Ca2+/calmodulin-regulated phosphodiesterase (PDE I) and myosin light chain kinase. Group: Biochemicals. Alternative Names: N-(6-Aminohexyl)-1-naphthalenesulfonamide Hydrochloride. Grades: Molecular Biology Grade. CAS No. 61714-25-8. Pack Sizes: 5mg, 25mg, 50mg, 100mg. Molecular Formula: C??H??ClN?O?S. US Biological Life Sciences. | Worldwide |
| Calmodulin Antagonist W-7 (Actomyosin Inhibitor) (N-(6-aminohexyl)-5-chloro-1-naphthalenesulfonamide hydrochloride) | W7 is a vascular relaxing agent which affects vascular smooth muscle actomyosin. W7, a Protein Kinase Inhibitor, is an inhibitor of actomyosin superprecipitation, produces relaxation of isolated rabbit arterial strips and antagonizes the contraction of the strips induced by various contractile agonists. W7 is also a calmodulin antagonist that binds to calmodulin and inhibits Ca2+/calmodulin-regulated enzyme activities. Group: Biochemicals. Alternative Names: N-(6-aminohexyl)-5-chloro-1-naphthalenesulfonamide hydrochloride. Grades: Molecular Biology Grade. CAS No. 61714-27-0. Pack Sizes: 100mg. US Biological Life Sciences. | Worldwide |
| CaSR antagonist 18c | A calcium-sensing receptor (CaSR) antagonist (IC50 = 76 nM) potentially used as an anabolic agent for the treatment of osteoporosis. Uses: Potential anabolic agent for osteoporosis. Grades: 99%. CAS No. 802916-30-9. Molecular formula: C32H35N3O6. Mole weight: 557.64. | |
| CB1 antagonist 4 | CB1 antagonist 4 (compound 8) is a peripheral selective cannabinoid receptor type 1 (CB1) receptor antagonist. CB1 antagonist 4 shows limited penetrance to the brain in order to minimize or prevent CNS adverse reactions, and preserves potential antiobesity effects. CB1 antagonist 4 reduces propensity for psychiatric side effects [1] [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1253641-65-4. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-112340. | |
| CB1 Antagonist AM251 (N-(Piperidin-1-yl)-5-(4-iodophenyl)-1-(2,4-dichlorophenyl)-4-methyl-1H-pyrazole-3-carboxamide, AM 251) | A potent and highly selective antagonist for cannabinoid subtyre 1 (CB1) receptor. Affinity for CB1 (IC50 = 8nM, Ki = 7.49nM) is more than 306-fold higher than that for CB2 receptors. Has been used in a study to determine its interaction with hippocampal neurons to enhance spatial memory in mice. Group: Biochemicals. Grades: Highly Purified. CAS No. 183232-66-8. Pack Sizes: 5mg. US Biological Life Sciences. | Worldwide |
| CB1R antagonist 1 | CB1R Allosteric modulator 5, a selective cannabinoid-1 receptor (CB1R) inverse agonist with an IC 50 value of 4.2 μM and EC 50 value of ?10 μM. CB1R Allosteric modulator 5 can be used for the research of metabolic and obesity [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 334668-69-8. Pack Sizes: 5 mg; 10 mg. Product ID: HY-150067. | |
| CCR1 antagonist | CCR1 antagonist is a chemokine CCR1 antagonist. It is used for the treatment of chronic obstructive pulmonary disease. Uses: Ccr1 antagonist is used for the treatment of chronic obstructive pulmonary disease. Synonyms: AZD-4818; AZD 4818; AZD4818. (S)-2-(2-chloro-5-(3-(5-chloro-3H-spiro[benzofuran-2,4'-piperidin]-1'-yl)-2-hydroxypropoxy)-4-(methylcarbamoyl)phenoxy)-;2-[2-Chloro-5-[(2S)-3-(5-chlorospiro[3H-1-benzofuran-2,4'-piperidine]-1'-yl)-2-hydroxypropoxy]-4-(methylcarbamoyl)phenoxy]-2-methylpropanoic acid. Grades: >98 %. CAS No. 1003566-93-5. Molecular formula: C27H32Cl2N2O7. Mole weight: 567.46. | |
| CCR3 antagonist 1 | A potent antagonist of CCR3 (IC50= 1.8 nM). Synonyms: CCR3 antagonist 1; CCR 3 antagonist 1; CCR-3 antagonist 1; 4-Thiazoleacetic acid, 2-[[2-[[[(2S)-4-[(3,4-dichlorophenyl)methyl]-2-morpholinyl]methyl]amino]-2-oxoethyl]thio]-. CAS No. 879399-82-3. Molecular formula: C19H21Cl2N3O4S2. Mole weight: 490.42. | |
| CCR4 Antagonist | A potent CCR4 antagonist. Synonyms: C 021 dihydrochloride; C021 dihydrochloride; C-021 dihydrochloride; 2-(1,4'-Bipiperidine-1'-yl)-N-cycloheptyl-6,7-dimethoxyquinazolin-4-amine; 2-(1,4'-Bipiperidin)-1'-yl-N-cycloheptyl-6,7-dimethoxy-4-quinazolinamine; C-021; CCR4 Antagonist; CHEMBL508207; 2-(1,4'-Bipiperidin)-1'-yl-N-cycloheptyl-6,7-dimethoxy-4-quinazolina. CAS No. 864289-85-0. Molecular formula: C27H41N5O2. Mole weight: 467.6. | |
| CCR5 antagonist 1 | CCR5 antagonist 1 is a CCR5 antagonist extracted from WO 2004054974 A2 that can inhibit HIV replication. Synonyms: AC-31371; HY-100261. Grades: >98%. CAS No. 716354-86-8. Molecular formula: C39H46ClF2N5O3S. Mole weight: 738.3. | |
| CGP 35348 (GABAB Receptor Antagonist, CGP 35348, CGP35348, CGP-35348) | A selective antagonist of post-synaptic GABAB receptors (IC50 = 34uM) that can permeate the blood brain barrier. Exhibits about 10-fold lower affinity for pre-synaptic receptors. Blocks K+-evoked glycine exocytosis in mouse spinal cord and hippocampal nerve endings. Shown to antagonize the potentiating effect of L-baclofen on noradrenaline-induced stimulation of adenylate cyclase in rat cortex slices. Group: Biochemicals. Grades: Highly Purified. CAS No. 123690-79-9. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| CGP 7930 (GABA B Receptor Antagonist, CGP7930, CGP 7930, CGP-7930) | A blood brain barrier permeable, positive allosteric modulator of the metabotropic GABAB receptor. Shown to modulate GABAB receptor in the high affinity state and thereby increases agonist affinity for the receptor. Also enhances agonist potency and efficacy even on recombinant GABAB receptors. Exhibits anxiolytic effects in rodents. Group: Biochemicals. Grades: Highly Purified. CAS No. 57717-80-3. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| CNS-1102 (N-(3-Ethylphenyl)-N-methyl-N'-1-naphthalenylguanidine Hydrochloride, Cerestat, Aptiganel Hydrochloride, NMDA Antagonist V) | A non-competitive, subunit non-selective, potent antagonist fornMDA receptors (IC50 = 0.13, 0.068, 0.087, and 0.14uM for NR2A - D, respectively). Widely used as neuroprotective agent after acute traumatic brain injury and stroke in animal researches. Group: Biochemicals. Grades: Highly Purified. CAS No. 137159-92-3. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| CP-101,606 (Traxoprodil, CP-101606, (1S,2S)-1-(4-hydroxy-phenyl)-2-(4-hydroxy-4-phenylpiperidino)-1-propanol, NMDA Antagonist VI) | A highly selective antagonist for NR2B subunit containing nMDA receptors (IC50 = 0.039uM for NR2B and >100uM for NR2A, NR2C, and NR2D). Widely used as neuroprotective, analgesic, antidepressant, and anti-Parkinsonian agent in research. Group: Biochemicals. Grades: Highly Purified. CAS No. 134234-12-1. Pack Sizes: 5mg. US Biological Life Sciences. | Worldwide |
| CPCCOEt ((E)-Ethyl 1, 1a, 7, 7a-tetrahydro-7- (hydroxyimino) cyclopropa[b]chromene-1a-carboxylate, mGlu1 Antagonist, CPCCOEt) | A potent, negative allosteric modulator selective for mGlu1 receptors (IC50 = 6.5uM). No effect on other mGlu subtype receptors and ionotropic glutamate receptors at concentrations less than 100uM. Acts by inhibiting an intramolecular interaction between the agonist-bound extracellular domain and the transmembrane domain. Widely used for studies related to peripheral pain and central pain pathways. Group: Biochemicals. Grades: Highly Purified. CAS No. 179067-99-3. Pack Sizes: 5mg. US Biological Life Sciences. | Worldwide |
| CTAP (Mu Opioid Receptor Antagonist, CTAP) | A highly potent octapeptide that acts as a selective and brain penetrating bioavailable u opioid receptor antagonist (IC50 = 3.5nM). Used in studies of reward systems and additions. Group: Biochemicals. Grades: Highly Purified. CAS No. 103429-32-9. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
| CTOP (Mu Opioid Receptor Antagonist, CTOP) | A potent antagonist highly selective for Mu opioid receptor (Ki = 0.96nM for u receptor and > 10,000nM for delta receptors). Often used for studying the functional roles of Mu opioid receptors in both central and peripheral nervous systems. Group: Biochemicals. Grades: Highly Purified. CAS No. 103429-31-8. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
| CXCR2 antagonist 2 | CXCR2 antagonist 2 is a potent CXCR2 antagonist for cancer immunoresearch with an IC 50 value of 95 nM. Uses: Scientific research. Group: Signaling pathways. CAS No. 2647464-91-1. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-139873. | |
| CXCR2 Antagonist, Cpd 19 (CXCR2 Inhibitor, 3-(2-(cyclopentylamino)-3,4-dioxocyclobut-1-enylamino)-2-hydroxy-N,N-dimethylbenzamide) | A cell-permeable, cyclobutenedione derivative that acts as a potent antagonist of chemokine receptor CXCR2 (IL8RB) (IC50 = 8nM). Reported to inhibit CXCR2-mediated chemotaxis in a CXCR2 expressing cell line (IC50 = 145nM). Exhibits good stability in human and rat liver microsomal preparations (>50% remaining after 30 min at 37°C). Group: Biochemicals. Grades: Highly Purified. CAS No. 473728-67-5. Pack Sizes: 2mg. US Biological Life Sciences. | Worldwide |
| CXCR3 Antagonist 6c | CXCR3 Antagonist 6c is a potent and selective chemokine CXCR3 antagonist (IC50 value of 60 nM in a calcium mobilization functional assay). It inhibits CXCR3 functional response to CXCL11 as measured by T-cell chemotaxis. Synonyms: 4-[2-[ (3-chlorobenzoyl) amino]-4-[2- (2, 4-dichlorophenyl) ethylcarbamoyl]phenyl]-N-ethyl-1, 4-diazepane-1-carboxamide. Grades: 99%. CAS No. 870998-13-3. Molecular formula: C30H32Cl3N5O3. Mole weight: 616.97. | |
| CXCR3 Antagonist (GPR9 Antagonist, 4-cyano-N- (3-fluoro-4- (1H-tetrazol-5-yl) benzyl) -N- (2-fluorobenzyl) benzenesulfonamide, AS612568, CD183 Antagonist) | An arylsulfonamide derivative that acts as a CXCR3 antagonist (IC50 = 192nM against CXCL10-induced chemotaxis of hCXCR3-overexpressing L1.2 cells) with good aqueous solubility (>100uM at pH 7.4). Shown to be orally available in mice (83% bioavailability; t1/2 = 1h; 10mg/kg p.o.) in vivo and display a medium intrinsic clearance (CIint = 17uL/min/mg) in in vitro mouse liver microsome stability test. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 1mg. Molecular Formula: C??H??F?N6O?S. US Biological Life Sciences. | Worldwide |
| CXCR4 Antagonist III (Fusin Antagonist III, N2- (4- ( (3- (Cyclohexylamino) propylamino) methyl) benzyl) -N4- (piperidin-4-yl) quinazoline-2,4-diamine, 2HCl) | A cell-permeable quinazoline compound that acts as a potent and reversible CXCR4 antagonist (IC50=36.2nM for SDF-1/CXCL12 binding to hCXCR4-transfected HEK293 membrane) with selectivity over closely related human chemokine receptors CXCR2, CCR2, CCR4 and CCR5 (IC50 >10uM). Shown to inhibit CXCL12-induced Ca2+-mobilization and cell migration in hCXCR4-HEK293 cells (IC50=100.1 and 41nM, respectively), and rapidly mobilize CXCR4+, CD34+ and CD133+ stem cells from bone marrow in C57BL/6 male mice (6mg/kg, s.c). Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| CXCR4 Antagonist IV, TF14016 (Fusin Antagonist IV) | A 14-aa internally disulfide-bonded peptide that potently competes against SDF-1alpha/CXCL12 for CXCR4 binding (IC50 = 0.91nM; [SDF-1] = 100nM) and protects MT-4 cells against X4-HIV strain HIV-1IIIB infection (EC50 = 4nM in 5 d; MOI = 0.01) with no significant cytotoxicity (CC50 = 56uM; 5 d). Inhibits SDF-1-induced Ca2+ mobilization (IC50 = 4.5nM; [SDF-1] = 30nM; CXCR4-expressing CHO cells) in vitro and effectively prevents CXCR4-dependent 5BC-5 metastasis in NK-depleted SCID mice in vivo (10mg/kg i.p.) in vivo. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 2mg. Molecular Formula: C???H???FN??O??S?. xH?O, Sequence: N alpha-4-fluorobenzoyl-Arg-Arg-Nal-Cys4-Tyr-Cit-Lys-D-Lys-Pro-Tyr-Arg-Cit-Cys¹3-Arg-NH2 (Disulfide bond: 4 ? 13; Nal = L-3-(2-naphthyl)alanine; Cit = L-citrulline). US Biological Life Sciences. | Worldwide |
| Cyclopamine-KAAD (3-Keto-N-aminoethyl-aminocaproyldi hydrocinnamoyl cyclopamine, Shh Signaling Antagonist II) | A potent, cell-permeable analog of Cyclopamine that specifically inhibits the Hedgehog (Hh) signaling with similar or lower toxicity (IC50 = 20nM in Shh-LIGHT2 assay; 50nM in p2Ptch-/-cells; 500nM in SmoA1-LIGHT cells). Binds to SmoA1 and promotes its exit from the endoplasmic reticulum. Suppresses both the ShhNp-induced pathway activity and SmoA1-induced reporter activity. Shown to sensitize human glioma cells to TRAIL-induced apoptosis. Group: Biochemicals. Grades: Purified. CAS No. 306387-90-6. Pack Sizes: 100ug. Molecular Formula: C??H??N?O?, Primary Target: Hh signaling in Shh-light2 assay. US Biological Life Sciences. | Worldwide |
| CysLT1 Antagonist Q8 | CysLT1 antagonist Q8 is a cysteinyl leukotreine (CysLT1) receptor antagonist inhibiting angiogenesis in transgenic fluorescent zebrafish, and human microvascular endothelial cell (HMEC-1) proliferation, tubule formation, and migration. CysLT1 antagonist Q8 exhibits antiangiogenic effect in a VEGF-independent in vitro model of angiogenesis and an additive antiangiogenic response with bevacizumab. Synonyms: Q8 hydrochloride; Q 8 hydrochloride; Q-8 hydrochloride; (E)-2-(2-Quinolin-2-yl-vinyl)-benzene-1,4-diol Hydrochloride. Grades: 99%. CAS No. 1541762-55-3. Molecular formula: C17H14ClNO2. Mole weight: 299.75. | |
| DNQX Disodium Salt (AMPA Glutamate Receptor Antagonist, DNQX, Kainate Glutamate Receptor Antagonist, DNQX) | A potent competitive antagonist selective for AMPA/kainate glutamate receptors (IC50 = 0.19-1.66uM and 0.35uM for AMPA and GluK2 receptors, respectively). Routinely used as a tool to distinguish the role of neurotransmissions mediated by AMPA/kainate andnMDA receptors in studying brain functions and disorders. Group: Biochemicals. Grades: Highly Purified. CAS No. 2379-57-9. Pack Sizes: 10mg. Molecular Formula: C?H?N?O?Na?, Primary Target: AMPA. US Biological Life Sciences. | Worldwide |
| Dopamine D2 receptor antagonist-1 | Dopamine D2 receptor antagonist-1 is a negative allosteric modulator (NAM) of the dopamine D2 receptor (D2R) with sub-mM affinity [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1055411-77-2. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-129946. | |
| DP2 Antagonist I (CRTH2 Antagonist I, GPR44 Antagonist I, (4-Chloro-2- ( (2-methyl-5- (propylsulfonyl) phenyl) ethynyl) phenoxy) acetic Acid) | A cell-permeable alkynylphenoxyacetic acid that acts as a high affinity antagonist against the G protein-coupled PGD2 receptor CRTH2/DP2 (Ki = 2.0 and 2.4nM against 1.5nM PGD2 for human & murine DP2 binding, respectively), exhibiting much reduced potency against DP1 (Ki = 1.58uM; IC50 = 10uM), PGE receptor EP2 (54% inhibition at 10uM), and little or no activity toward 49 other receptors and ion channels. Effectively inhibits PGD2-induced cellular activation (IC50 = 32 and 80nM, respectively, using CHO-CRTH2 or human whole blood) in vitro and is efficacious in alleviating airway eosinophil infiltration in OVA-sensitized mice (30mg/kg; p.o.) in vivo with good oral bioavailability. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 2mg. Molecular Formula: C??H??ClO?S. US Biological Life Sciences. | Worldwide |
| DP2 Antagonist II (CRTH2 Antagonist II, GPR44 Antagonist II, (R)-(5-Chloro-1'-(5-chloro-2-fluorobenzyl)-2,2',5'-trioxospiro(indole-3,3?-pyrrolidin)-1(2H)-yl)acetic Acid) | The (R) enantiomer of a cell-permeable alkynylphenoxyacetic acid that acts as a high affinity antagonist against the G protein-coupled PGD2 receptor CRTH2/DP2 (Ki = 5.3 and 5.0nM against human & murine DP2, respectively), exhibiting much reduced potency against a panel of more than 50 other receptors and ion channels. Effectively inhibits DP2-dependent chemotaxis of primary human eosinophils (IC50 = 100nM). Exhibits higher Caco-2 permeability than DP2 Antagonist I, but less oral bioavailability in mice. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 2mg. Molecular Formula: C??H??Cl?FN?O?. US Biological Life Sciences. | Worldwide |
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