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| Product | Description | |
|---|---|---|
| Antagonist G | Antagonist G. Group: Biochemicals. Grades: Purified. CAS No. 115150-59-9. Pack Sizes: 1mg. US Biological Life Sciences. |  Worldwide |
| Antagonist G | Antagonist G is a substance P analog, which is a broad spectrum neuropeptide growth factor antagonist and antiproliferative agent. It was developed for the treatment of small cell lung cancer. It could inhibit neuropeptide-dependent and -independent proliferation of small cell lung cancer in vitro. It also inhibits growth of SCLC xenografts in mice in vivo. It blocks Swiss 3T3 cell growth induced by vasopressin, gastrin-releasing peptide and bradykinin. It activates JNK and stimulates apoptosis. It is an anticancer agent and is resistant to degradation by peptidases. Synonyms: [Arg6,D-Trp7,9,N-MePhe8]-Substance P(6-11). Grade: 98%. CAS No. 115150-59-9. Molecular formula: C49H66N12O6S. Mole weight: 951.20. |  |
| 14-3-3 Antagonist I, 2-5 ( (S) -2- (2- (4-Azidobenzamido) acetamido) -3- ( (4-hydroxyphenethyl) amino) -3-oxopropyl-dihydrogen Phosphate) | A cell-permeable dipeptidyl-phosphoserine compound that effectively disrupts 14-3-3 interaction with its ligands (IC50=2.6uM against TMR-GG-RLSHpSSLPG binding to human 14-3-3 sigma), including Raf-1 and p53. Shown to induce caspase-3 activation and apoptotic cell death in human lung adenocarcinoma A549 cultures (100uM) in a time-dependent manner. Group: Biochemicals. Grades: Purified. Pack Sizes: 5mg. Molecular Formula: C??H??N?O?P, Molecular Weight: 506.4. US Biological Life Sciences. | Worldwide |
| 2,3 cis-Piperidine Dicarboxylic Acid (Ionotropic Glutamate Receptor Antagonist, PDA, cis PDA, cis-Piperidine-2,3-dicarboxylic Acid) | A non-specific antagonist of NMDA, AMPA and kainate ionotropic receptors and a partial agonist for NMDA receptors. Used in blocking general excitatory synaptic transmissions. Group: Biochemicals. Grades: Highly Purified. CAS No. 46026-75-9. Pack Sizes: 50mg. US Biological Life Sciences. | Worldwide |
| 5-HT2A antagonist 1 | 5-HT2A antagonist 1 is a 5-HT2A antagonist extracted from patent US5728835A and JP 1007727. It may be useful in treatment of gastrointestinal disorders circulatory disorders. Synonyms: Benzamide, 4-amino-N-[2-(4-benzoyl-1-piperidinyl)?ethyl]?-N-3-pyridinyl-. CAS No. 204643-75-4. Molecular formula: C26H28N4O2. Mole weight: 428.53. | |
| 5-HT3 antagonist 3 | 5-HT3 antagonist 3 is a compound which can be used to treat gastro intestinal functional disorders in the lower intestinal tracts extracted from patent DE 4238553 A1. 5-HT3 antagonist 3 is a high-affinity 5-HT3 receptor antagonist. 5-HT3 antagonist 3 binds to 5-HT3 receptors in rat brain cortical membranes with Ki of 0.25 nM. Synonyms: Imidazol-1-yl compound 1; 10-((2-methyl-1H-imidazol-1-yl)methyl)-5,6,9,10-tetrahydro-4H-pyrido[3,2,1-jk]carbazol-11(8H)-one. CAS No. 120635-47-4. Molecular formula: C20H21N3O. Mole weight: 319.40. | |
| 5-HT3 antagonist 5 | 5-HT3 antagonist 5 is a quinoxalin-2-carboxamide compound, a 5-HT 3 receptor antagonist. 5-HT3 antagonist 5 exerts antagonism on 5-HT 3 agonist and 2-methyl-5-HT , and shows anti-depressant effect in mice [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 901599-43-7. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-148038. |  |
| 5-HT6/7 antagonist 1 | 5-HT6/7 antagonist 1 is a multifunctional ligand that antagonizes 5-HT6/7/2A and D2 receptors and does not interact with M1 receptors and hERG channels. Synonyms: 1H-Isoindole-1,3(2H)-dione, 2-[2-[4-(6-fluoro-1,2-benzisoxazol-3-yl)-1-piperidinyl]ethyl]-; N-[2-[4-(6-Fluoro-1,2-benzisoxazol-3-yl)-1-piperidinyl]ethyl]phthalimide; 2-{2-[4-(6-Fluoro-1,2-benzoxazol-3-yl)-1-piperidinyl]ethyl}-1H-isoindole-1,3(2H)-dione. Grade: ≥95%. CAS No. 131999-28-5. Molecular formula: C22H20FN3O3. Mole weight: 393.41. | |
| 5-HT6 antagonist 29 | A brain penetrant 5-HT6 receptor antagonist (pKi value 8.6). Synonyms: 5-HT6 antagonist 29; 497963-70-9; 3-(4-chlorophenyl)sulfonyl-1-methyl-7-piperazin-1-ylindole; hydrochloride; PD016667; E98892; 3-(4-chlorophenylsulfonyl)-1-methyl-7-(piperazin-1-yl)-1H-indole hydrochloride. Grade: 99%. CAS No. 497963-70-9. Molecular formula: C19H20ClN3O2S.HCl. Mole weight: 426.36. | |
| 5-HT7R antagonist 1 | 5-HT7R antagonist 1 is a G protein-biased antagonist against 5-HT7R with a Ki of 6.5 nM. Synonyms: 5-HT7R antagonist 1; CS-0227255. Molecular formula: C14H18Cl2N4. Mole weight: 313.23. | |
| 5-HT7R antagonist 1 free base | 5-HT7R antagonist 1 free base is a G protein-biased antagonist against 5-HT7R with a Ki of 6.5 nM. CAS No. 2337008-64-5. Molecular formula: C14H17ClN4. Mole weight: 276.76. | |
| A2AR antagonist 1 | A2AR antagonist 1 is a potent A2AR (Adenosine A2A Receptor) antagonist with Ki values of 4 nM and 264 nM for A2AR and A1R, respectively. Synonyms: 1-[(2-fluorophenyl)methyl]-4-(furan-2-yl)pyrazolo[3,4-d]pyrimidin-6-amine. Grade: ≥95%. CAS No. 443103-97-7. Molecular formula: C16H12FN5O. Mole weight: 309.30. | |
| A2A receptor antagonist 1 | A2A receptor antagonist 1 (CPI-444 analog) is an antagonist of both adenosine A 2A receptor and A 1 receptor with K i values of 4 and 264 nM, respectively [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: CPI-444 analog. CAS No. 443103-97-7. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-102024. | |
| A2B receptor antagonist 2 | A2B receptor antagonist 2 is a member of quinazolines. It is also an adenosine receptor A2B antagonist, with Ki values of 2.30 μM, 6.8 μM and 3.44 μM for rA1, rA2A and hA2B, respectively. Synonyms: N-(4,6,7-trimethylquinazolin-2-yl)guanidine; 1-(4,6,7-trimethylquinazolin-2-yl)guanidine. Grade: 95%. CAS No. 784-90-7. Molecular formula: C12H15N5. Mole weight: 229.28. | |
| A317491 ((S)-5-((3-phenoxybenzyl)(1,2,3,4-tetrahydronaphthalen-1-yl)carbamoyl)benzene-1,2,4-tricarboxylic Acid, P2X3 Purinergic Receptors Antagonist, A317491, P2X2/3 Purinergic Receptors Antagonist, A317491, A 317491) | A potent, selective, and competitive non-nucleotide antagonist of P2X3 and P2X2/3 receptors that blocks receptor-mediated Ca2+ flux (Ki = 22 and 92nM for rat P2X3 and P2X2/3 receptor and 22 and 9nM for human P2X3 and P2X2/3 receptor, respectively). Its R-enantiomer has significantly reduced activity at these receptors. Exhibits high selectivity over other purinergic receptors. Shown to reduce thermal and mechanical hyperalgesia in rat models (ED50 = 10-15uM/kg, s.c). Its anti-nociceptive effects have a rapid on-set and persist for up to 5 hours after sub-cutaneous administration. Also shown to block dorsal root ganglion currents in a dose-dependent manner (IC50 = 15nM). Group: Biochemicals. Grades: Highly Purified. CAS No. 475205-49-3. Pack Sizes: 5mg. Molecular Formula: C??H??NO? xH2O xNa. US Biological Life Sciences. | Worldwide |
| Adenosine A1 Receptor Antagonist I, DPCPX (8-Cyclopentyl-1,3-dipropylxanthine, CPX, PD-116,948) | A blood-brain barrier permeable xanthine derivative that acts as a highly selective antagonist of Adenosine A1 receptor (A1R; Ki = 3.9nM, 130nM, 1.0uM, 4.0uM for human A1, A2A, A2B, and A3 respectively). Exhibits about 1,000-fold higher affinity and a 30-fold greater selectivity for A1R when compared to theophylline. Shown to competitively antagonize the inhibition of adenylate cyclase activity via A1 adenosine receptors in rat fat cells and the stimulation of adenylate cyclase via A2 adenosine receptors in human platelets. Exhibits hypertensive properties. Group: Biochemicals. Grades: Highly Purified. CAS No. 102146-07-6. Pack Sizes: 25mg. Molecular Formula: C??H??N?O?, Primary Target: A1. US Biological Life Sciences. | Worldwide |
| Adenosine A2A/A1 Receptor Antagonist (2-Amino-8-(2-morpholinoethoxy)-4-phenyl-5H-indeno[1,2-d]-pyrimidin-5-one, diHCl) | A blood-brain barrier-permeant indenopyrimidinone that acts as a dual A1/A2A antagonist (Ki = 48.2 and 6.5nM, respectively, against agonist-induced cAMP response in A1- or A2A-expressing CHO-K1 cells) and effectively reverses D2 antagonist haloperidol- (1mg/kg; s.c.) induced catalepsy in both rats and mice (ED50 = 0.3 and <0.1mg/kg, respectively) in vivo by simultaneously reversing A1-mediated inhibition of DA (Dopamine) release and A2A-dependent inhibition of D2 receptor response to DA. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| Adenosine A 2A/A? Receptor Antagonist | The Adenosine A2A/A? Receptor Antagonist controls the biological activity of Adenosine A2A/A? Receptor. This small molecule/inhibitor is primarily used for Biochemicals applications. Group: Fluorescence/luminescence spectroscopy. |  |
| Adenosine A2A Receptor Antagonist II, SCH-58261 (2-(furan-2-yl)-7-phenethyl-7H-pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidin-5-amine, SCH58261, SCH 58261) | A highly potent and selective antagonist of adenosine A2A receptor (Ki = 600pM). Does not affect the activity of other adenosine receptors in any significant manner (Ki = 287nM; 5uM, and > 10uM for A1, A2B, and A3 receptors, respectively). Displays neuroprotective effects in cerebral ischaemia in rats, and shown to counteract Parkinsonian-like muscle rigidity in rats. CAS Number:160098-96-4. Group: Biochemicals. Grades: Highly Purified. CAS No. 160098-96-4. Pack Sizes: 10mg. Molecular Formula: C??H??N?O, Primary Target: A2A Receptor. US Biological Life Sciences. | Worldwide |
| Adenosine A3 Receptor Antagonist, MRS 1523 (3-propyl-6-ethyl-5[(ethylthio)carbonyl]-2-phenyl-4-propyl-3-pyridine-carboxylate, MRS 1523, MRS-1523) | A pyridine derivative that acts as a highly selective antagonist of A3 receptor with excellent potency in both humans and rodents (Ki = 18.9nM for human A3R, and 113nM for rat A3R). Exhibits only a trivial antagonistic activity towards A1 and A2A receptors (Ki = 15.6uM and 2.05uM for rat A1R and A2AR, respectively). Abolishes the agonistic effects of Cl-IB-MECA on A3R-mediated proliferation of primary human coronary smooth muscle cells. Also, reported to block NECA-induced bronchoconstriction in an allergic murine model. Group: Biochemicals. Grades: Highly Purified. CAS No. 212329-37-8. Pack Sizes: 5mg. Molecular Formula: C??H??NO?S. US Biological Life Sciences. | Worldwide |
| Adenosine antagonist-1 | Adenosine antagonist-1 is an adenosine A3 receptor ( AA3R ) antagonist. Uses: Scientific research. Group: Signaling pathways. CAS No. 431040-19-6. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-100274. | |
| Adenosine receptor antagonist 2 | Adenosine receptor antagonist 2 is an orally active A2a/A2b adenosine receptor antagonist with IC 50 s of 1 nM and 3 nM, respectively. Adenosine receptor antagonist 2 has anti-tumor activity [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2703054-47-9. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-144064. | |
| Adenosine receptor antagonist 3 | Adenosine receptor antagonist 3 is a potent antagonist of adenosine receptor. Adenosine receptor antagonist 3 has the potential for the research of cancer disease (extracted from patent WO2019233994A1, compound 1) [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2400864-80-2. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-144419. | |
| AF353 (P2X3 Purinergic Receptor Antagonist, AF353, P2X2/3 Purinergic Receptor Antagonist, AF353) | A novel, potent, orally bioavailable antagonist of P2X3/P2X2/3 receptors (pIC50 = 8 in human and rat; pIC50 = 7.3 for human P2X2/3 receptor). Shown to be highly brain penetrant with a brain to plasma ratio of 6. Blocks agonist-evoked intracellular Ca2+ flux and inward currents in nanomolar range (10nM to 1uM) in cell lines recombinantly expressing human P2X3 and P2X2/3 receptors. Exhibits desirable pharmacokinetic properties (t1/2 = 1.63 h and Tmax = 30 min). Group: Biochemicals. Grades: Highly Purified. CAS No. 927887-18-1. Pack Sizes: 5mg. Molecular Formula: C??H??ClIN?O?. US Biological Life Sciences. | Worldwide |
| AF-DX 116 (Muscarinic Receptor (mAChR) M2 Antagonist, AF-DX 116, Otenzepad, AF-DX116, AF-DX-116, AFDX116) | Selective presynaptic muscarinic receptor M2 antagonist with cardioselectivity. Exhibits antiarrhythmic effects in vivo, also shown to reverse the memory impairment effect of insulin in a mouse model. Group: Biochemicals. Grades: Highly Purified. CAS No. 102394-31-0. Pack Sizes: 10mg. Molecular Formula: C??H??N?O?. US Biological Life Sciences. | Worldwide |
| AHR antagonist 2 | AHR antagonist 2 is a potent aryl hydrocarbon receptor (AHR) antagonist, extracted from patent WO2019101641A1, compound example 1. Synonyms: AHR antagonist 2; 2338747-54-7; SCHEMBL21001701; CSSGBPKFVJOAIZ-LBPRGKRZSA-N; AKOS040732400; MS-27306; HY-135831; CS-0114332; N-[(2S)-1-hydroxypropan-2-yl]-2-pyridin-3-yl-6-[4-(trifluoromethoxy)phenyl]pyrimidine-4-carboxamide. Grade: 99%. CAS No. 2338747-54-7. Molecular formula: C20H17F3N4O3. Mole weight: 418.37. | |
| AHR Antagonist 5 | AHR Antagonist 5, an effective and orally active aromatic hydrocarbon receptor (AHR) antagonist with IC50 of less than 0.5 μM. It can significantly inhibit tumor growth in combination with the checkpoint inhibitor anti-PD-1. Synonyms: BCP33104; HY-136220; CS-0120848; (R)-N-(2-(5-Fluoropyridin-3-Yl)-8-Isopropylpyrazolo[1,5-A][1,3,5]Triazin-4-Yl)-2,3,4,9-Tetrahydro-1H-Carbazol-3-Amine Trihydrochloride. Grade: ≥98% by HPLC. CAS No. 2247953-39-3. Molecular formula: C25H27Cl3FN7. Mole weight: 550.9. | |
| AHR antagonist 5 hemimaleate | AHR antagonist 5 hemimaleate is a potent and orally active aryl hydrocarbon receptor (AHR) antagonist with an IC50 of < 0.5 μΜ. AHR antagonist 5 hemimaleate significantly inhibits tumor growth combined with checkpoint inhibitor anti-PD-1. Molecular formula: C29H28FN7O4. Mole weight: 499.55. | |
| AhR Antagonist III, GNF351 | AhR Antagonist III, GNF351, is a cell-permeable, high-affinity aryl hydrocarbon receptor (AhR) antagonist (IC50 = 62 nM in mouse liver cytosol expressing humanized AhR). Group: Fluorescence/luminescence spectroscopy. | |
| AhR Antagonist III, GNF351 (N-(2-(3H-Indol-3-yl)ethyl)-9-isopropyl-2-(5-methyl-3-pyridyl)-7H-purin-6-amine, N-(2-(1H-Indol-3-yl)ethyl)-9-isopropyl-2-(5-methylpyridin-3-yl)-9H-purin-6-amine) | A cell-permeable purine compound that acts as a high-affinity aryl hydrocarbon receptor (AhR) antagonist (IC50 = 62nM in mouse liver cytosol expressing humanized AhR) and lacks any agonist activity even at higher doses. Reportedly binds with high affinity to the ligand-binding pocket of AhR and blocks the binding of an array of exogenous and endogenous ligands. Shown to non-covalently interact with Ser317, His291, and Ser365 in human and with Ser311, His285, and Ser359 in mouse AhR. Represses AhR transcriptional activity via the dioxin response element (DRE)-dependent and independent mediated responses in human and mouse cells (IC50 = 8.5nM in HepG2 40/6 cells). Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| AMPA/kainate antagonist-1 | AMPA/kainate antagonist-1 is a non-competitive AMPA/kainate antagonist. Synonyms: (r)-(+)-8-methyl-5-(3-methyl-4-nitrophenyl)-8,9-dihydro-7h-1,3-dioxolo[4,5-h][2,3]benzodiazepine. Grade: 98%. CAS No. 732277-05-3. Molecular formula: C18H17N3O4. Mole weight: 339.3. | |
| AMPA/Kainate Antagonist-2 | AMPA/kainate antagonist-2 is a non-competitive AMPA/kainate antagonist. Synonyms: AMPA/kainate antagonist-2; 923271-87-8; AMY40928BCP34146(+)-5-(4-amino-3-methylphenyl)-7-(2-thiazolyl)-8,9-dihydro-7H-1,3-dioxolo-[4,5-h][2,3]benzodiazepine. Grade: 98%. CAS No. 923271-87-8. Molecular formula: C20H18N4O2S. Mole weight: 378.4. | |
| AMPA/kainate antagonist-3 | AMPA/kainate antagonist-3 is a non-competitive AMPA/kainate antagonist. Grade: 98%. CAS No. 732278-52-3. Molecular formula: C21H21N5O2S. Mole weight: 407.5. | |
| Androgen receptor antagonist 1 | Androgen receptor antagonist 1 is an orally available full androgen receptor antagonist (IC50 = 59 nM). It can be used in the synthesis of PROTAC AR degraders, which results in 24% and 47% AR protein degradation in LNCaP cells at 1 μM and 10 μM, respectively. Synonyms: Androgen receptor antagonist 1; 1338812-36-4; CHEMBL1916251; SCHEMBL17941138; SCHEMBL17947423; BDBM50356995; AKOS040732433; MS-27273; HY-130992; CS-0120091; N-[3-(3-chloro-4-cyanophenoxy)-2,2,4,4-tetramethylcyclobutyl]-1-(2-hydroxyethyl)pyrazole-4-carboxamide. Grade: 99%. CAS No. 1338812-36-4. Molecular formula: C21H25ClN4O3. Mole weight: 416.90. | |
| ARE Activator, BTZO-1 (Macrophage Migration Inhibitory Factor Antagonist II, 2-Pyridin-2-yl-4H-1,3-benzothiazin-4-one, MIF Antagonist II) | A cell-permeable benzothiazinone that is shown to interact with MIF homotrimer (=68.6nM and 157nM toward human and rat MIF, respectively, at pH 7.3) via the N-terminal proline in a pH-dependent manner, limiting its inhibitory capability against MIF tautomerase activity (13% inhibition at pH 6.0; [BTZO-1] = 30uM) due to reduced MIF binding at acidic pH. Shown to protect primary rat cardiomyocytes (330nM) from apoptotic death upon serum deprivation or DOX (200nM) treatment via activation of ARE- (antioxidant response element) mediated cytoprotective genes transcription in a MIF-dependent manner. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 10mg. Molecular Formula: C??H?N?OS, Molecular Weight: 240.3. US Biological Life Sciences. | Worldwide |
| (+/-)-Atenolol ( (±) -4- {2-Hydroxy-3- [ (1-methylethyl) amino] propoxy} benzeneacetamide, Beta1-Adrenergic Receptor Blocker, (±)-Atenolol, Beta1-Adrenergic Receptor Antagonist, (±)-Atenolol) | Selective beta-1 adrenergic blocking agent. An anti-hypertensive and anti-arrhythmic agent. Reported to diminish cerebrospinal fluid production. Group: Biochemicals. Grades: Highly Purified. CAS No. 29122-68-7. Pack Sizes: 1g. Molecular Formula: C??H??N?O?. US Biological Life Sciences. | Worldwide |
| Bcl-xL antagonist 2 | Bcl-xL antagonist 2 is a potent, selective and orally active antagonist of Bcl-XL with IC50 and Ki of 0.091 μM and 65 nM, respectively. Bcl-xL antagonist 2 promotes apoptosis of cancer cells, and has the potential to study chronic lymphocytic leukemia (CLL) and non-Hodgkin's lymphoma (NHL). Synonyms: 4-Thiazolecarboxylic acid, 2-[8-[(2-benzothiazolylamino)carbonyl]-3,4-dihydro-2(1H)-isoquinolinyl]-; 2-(8-(Benzo[d]thiazol-2-ylcarbamoyl)-3,4-dihydroisoquinolin-2(1H)-yl)thiazole-4-carboxylic acid; 2-[8-(1,3-Benzothiazol-2-ylcarbamoyl)-3,4-dihydro-2(1H)-isoquinolinyl]-1,3-thiazole-4-carboxylic acid. Grade: ≥98%. CAS No. 1235032-75-3. Molecular formula: C21H16N4O3S2. Mole weight: 436.51. | |
| β-FXR antagonist 1 | β-FXR antagonist 1 (C 12), an isomer of FXR antagonist 1 (HY-151481) is a FXR antagonist [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2295804-92-9. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-151481A. | |
| Bicuculline, 98+% (GABAA Receptor Antagonist, (+)-Bicuculline) | A potent allosteric antagonist of vertebrate GABAA receptors. Blocks GABAA-induced chloride currents in cultured neurons (IC50 = 740nM). Shown to increase blood pressure in spontaneously hypertensive rats and cause convulsion in experimental animals. Also, increases the amplitude of spontaneous colonic contractions. Group: Biochemicals. Alternative Names: (6R)-6-[(5S)-5,6,7,8-Tetrahydro-6-methyl-1,3-dioxolo[4,5-g]lisoquinolin-5-yl]furo[3,4-e]-1,3-benzodioxol-8(6H)-one; (+)-Bicuculline; d-Bicuculline; NSC 32192. Grades: Highly Purified. CAS No. 485-49-4. Pack Sizes: 100mg, 250mg. Molecular Formula: C??H??NO?, Molecular Weight: 367.35. US Biological Life Sciences. | Worldwide |
| Bicuculline, 99+% (GABAA Receptor Antagonist, (+)-Bicuculline) | A potent allosteric antagonist of vertebrate GABAA receptors. Blocks GABAA-induced chloride currents in cultured neurons (IC50 = 740nM). Shown to increase blood pressure in spontaneously hypertensive rats and cause convulsion in experimental animals. Also, increases the amplitude of spontaneous colonic contractions. Group: Biochemicals. Alternative Names: (6R)-6-[(5S)-5,6,7,8-Tetrahydro-6-methyl-1,3-dioxolo[4,5-g]lisoquinolin-5-yl]furo[3,4-e]-1,3-benzodioxol-8(6H)-one; (+)-Bicuculline; d-Bicuculline; NSC 32192. Grades: Highly Purified. CAS No. 485-49-4. Pack Sizes: 50mg. Molecular Formula: C??H??NO?, Molecular Weight: 367.35. US Biological Life Sciences. | Worldwide |
| Bicuculline (GABAA Receptor Antagonist, (+)-Bicuculline) | Bicuculline (GABAA Receptor Antagonist, (+)-Bicuculline). Group: Biochemicals. Alternative Names: (6R)-6-[(5S)-5,6,7,8-Tetrahydro-6-methyl-1,3-dioxolo[4,5-g]lisoquinolin-5-yl]furo[3,4-e]-1,3-benzodioxol-8(6H)-one; (+)-Bicuculline; d-Bicuculline; NSC 32192. Grades: Plant Grade. CAS No. 485-49-4. Pack Sizes: 20mg. Molecular Formula: C20H17NO6, Molecular Weight: 367.351999999999. US Biological Life Sciences. | Worldwide |
| Calcium Channel antagonist 2 | Calcium Channel antagonist 2 (Compound 154) is a calcium channel antagonist ( IC 50 =5-20 μM). Calcium Channel antagonist 2 can be used in study of calcium channel-mediated diseases such as pain and diabetes [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 874370-15-7. Pack Sizes: 10 mg. Product ID: HY-156663. | |
| Calcium Channel antagonist 3 | Calcium Channel antagonist 3 (compound 397) is an inhibitor of voltage-gated calcium channels with an IC 50 value of 5-20μM [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 687573-14-4. Pack Sizes: 5 mg; 10 mg. Product ID: HY-156664. | |
| Calcium Channel antagonist 4 | Calcium Channel antagonist 4 (compound 189) is an inhibitor of voltage-gated calcium channels with an IC 50 value of 5-20μM [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 687574-49-8. Pack Sizes: 10 mg. Product ID: HY-156669. | |
| Calcium-Sensing Receptor Antagonists I | Calcium-Sensing Receptor Antagonists I is an antagonist of calcium-sensing parathyroid hormone receptors. Synonyms: 2(1H)-Quinazolinone, 1-(1-methylethyl)-4-[4-(1-methylethyl)phenyl]-6-(2-propyn-1-yloxy)-. Grade: >98%. CAS No. 478963-79-0. Molecular formula: C23H24N2O2. Mole weight: 360.45. | |
| Calmodulin antagonist-1 | Calmodulin antagonist-1 is a calmodulin (CaM) antagonist that inhibits calmodulin-activated Ca2+-phosphodiesterase (PDE) (IC50 = 28 μM). Calmodulin antagonist-1 also inhibits trypsin-treated Ca2+-PDE (IC50 = 375 μM) in a competitive fashion with respect to cyclic GMP (Ki = 300 μM). Uses: Neoplasm inhibitor. Synonyms: N-(4-Aminobutyl)-5-chloro-1-naphthalenesulfonamide Hydrochloride; W8 Hydrochloride; N-(4-Aminobutyl)-5-chloro-1-naphthalenesulfonamide Monohydrochloride. Grade: ≥95%. CAS No. 78957-84-3. Molecular formula: C14H18Cl2N2O2S. Mole weight: 349.28. | |
| Calmodulin Antagonist W-12 (N-(4-aminobutyl)-2-naphthalenesulfonamide hydrochloride) | Antagonist of calmodulin, inhibiting activation of Ca2+/calmodulin-dependent phosphodiesterase (PDE I) and myosin light chain kinase. Group: Biochemicals. Alternative Names: N-(4-aminobutyl)--2-naphthalenesulfonamide hydrochloride. Grades: Molecular Biology Grade. CAS No. 89108-46-3. Pack Sizes: 25mg. US Biological Life Sciences. | Worldwide |
| Calmodulin Antagonist W-13 (N-(4-aminobutyl)-5-chloro-2-naphthalenesulfonamide hydrochloride) | An Ergosterol Biosynthesis inhibitor. Group: Biochemicals. Alternative Names: N-(4-aminobutyl)-5-chloro-2-naphthalenesulfonamide hydrochloride. Grades: Molecular Biology Grade. CAS No. 88519-57-7. Pack Sizes: 5mg, 25mg. US Biological Life Sciences. | Worldwide |
| Calmodulin Antagonist W-5 | Antagonist of calmodulin, inhibiting Ca2+/calmodulin-regulated phosphodiesterase (PDE I) and myosin light chain kinase. Group: Biochemicals. Alternative Names: N-(6-Aminohexyl)-1-naphthalenesulfonamide Hydrochloride. Grades: Molecular Biology Grade. CAS No. 61714-25-8. Pack Sizes: 5mg, 25mg, 50mg, 100mg. Molecular Formula: C??H??ClN?O?S. US Biological Life Sciences. | Worldwide |
| Calmodulin Antagonist W-7 (Actomyosin Inhibitor) (N-(6-aminohexyl)-5-chloro-1-naphthalenesulfonamide hydrochloride) | W7 is a vascular relaxing agent which affects vascular smooth muscle actomyosin. W7, a Protein Kinase Inhibitor, is an inhibitor of actomyosin superprecipitation, produces relaxation of isolated rabbit arterial strips and antagonizes the contraction of the strips induced by various contractile agonists. W7 is also a calmodulin antagonist that binds to calmodulin and inhibits Ca2+/calmodulin-regulated enzyme activities. Group: Biochemicals. Alternative Names: N-(6-aminohexyl)-5-chloro-1-naphthalenesulfonamide hydrochloride. Grades: Molecular Biology Grade. CAS No. 61714-27-0. Pack Sizes: 100mg. US Biological Life Sciences. | Worldwide |
| CaSR antagonist 18c | A calcium-sensing receptor (CaSR) antagonist (IC50 = 76 nM) potentially used as an anabolic agent for the treatment of osteoporosis. Uses: Potential anabolic agent for osteoporosis. Grade: 99%. CAS No. 802916-30-9. Molecular formula: C32H35N3O6. Mole weight: 557.64. | |
| CB1 antagonist 1 | CB1 antagonist 1 is a CB1 receptor antagonist, used for the study of metabolic syndrome and obesity, neuroinflammatory disorders, cognitive disorders and psychosis, gastrointestinal diseases and cardiovascular diseases. Synonyms: Benzonitrile, 3-chloro-4-[2-(4-chlorophenyl)?-4-[1-(4-cyanophenyl)?ethyl]?-1-piperazinyl]?-; 3-Chloro-4-{2-(4-chlorophenyl)-4-[1-(4-cyanophenyl)ethyl]-1-piperazinyl}benzonitrile. Grade: ≥97%. CAS No. 890037-68-0. Molecular formula: C26H22Cl2N4. Mole weight: 461.39. | |
| CB1 antagonist 4 | CB1 antagonist 4 (compound 8) is a peripheral selective cannabinoid receptor type 1 (CB1) receptor antagonist. CB1 antagonist 4 shows limited penetrance to the brain in order to minimize or prevent CNS adverse reactions, and preserves potential antiobesity effects. CB1 antagonist 4 reduces propensity for psychiatric side effects [1] [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1253641-65-4. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-112340. | |
| CB1 Antagonist AM251 (N-(Piperidin-1-yl)-5-(4-iodophenyl)-1-(2,4-dichlorophenyl)-4-methyl-1H-pyrazole-3-carboxamide, AM 251) | A potent and highly selective antagonist for cannabinoid subtyre 1 (CB1) receptor. Affinity for CB1 (IC50 = 8nM, Ki = 7.49nM) is more than 306-fold higher than that for CB2 receptors. Has been used in a study to determine its interaction with hippocampal neurons to enhance spatial memory in mice. Group: Biochemicals. Grades: Highly Purified. CAS No. 183232-66-8. Pack Sizes: 5mg. US Biological Life Sciences. | Worldwide |
| CB1R antagonist 1 | CB1R Allosteric modulator 5, a selective cannabinoid-1 receptor (CB1R) inverse agonist with an IC 50 value of 4.2 μM and EC 50 value of ?10 μM. CB1R Allosteric modulator 5 can be used for the research of metabolic and obesity [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 334668-69-8. Pack Sizes: 5 mg; 10 mg. Product ID: HY-150067. | |
| CCK-B Receptor Antagonist 1 | CCK-B Receptor Antagonist 1 is a cholecystokinin B (CCK-B) receptor antagonist with the potential to reduce gastric acid secretion. Synonyms: Urea, N-[1-(3,3-dimethyl-2-oxobutyl)-2,3-dihydro-2-oxo-5-(2-pyridinyl)-1H-1,4-benzodiazepin-3-yl]-N'-[3-(methylamino)phenyl]-; 1-[1-(3,3-Dimethyl-2-oxobutyl)-2-oxo-5-(2-pyridinyl)-2,3-dihydro-1H-1,4-benzodiazepin-3-yl]-3-[3-(methylamino)phenyl]urea. Grade: ≥99%. CAS No. 168161-71-5. Molecular formula: C28H30N6O3. Mole weight: 498.58. | |
| CCK-B Receptor Antagonist 2 | CCK-B Receptor Antagonist 2, a potent and orally active Gastrin/CCK-B antagonist (IC50 = 0.43 nM), also inhibits gastrin/CCK-A activity with an IC50 of 1.82 μM. Synonyms: (R)-1-(3-Aminophenyl)-3-(1-(3,3-dimethyl-2-oxobutyl)-2-oxo-5-(pyridin-2-yl)-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl)urea; 1-(3-Amino-phenyl)-3-[(R)-1-(3,3-dimethyl-2-oxo-butyl)-2-oxo-5-pyridin-2-yl-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl]-urea; 1-(3-Aminophenyl)-3-[(3R)-1-(3,3-dimethyl-2-oxobutyl)-2-oxo-5-(2-pyridinyl)-2,3-dihydro-1H-1,4-benzodiazepin-3-yl]urea. Grade: ≥98%. CAS No. 155412-88-7. Molecular formula: C27H28N6O3. Mole weight: 484.55. | |
| CCR1 antagonist | CCR1 antagonist is a chemokine CCR1 antagonist. It is used for the treatment of chronic obstructive pulmonary disease. Uses: Ccr1 antagonist is used for the treatment of chronic obstructive pulmonary disease. Synonyms: AZD-4818; AZD 4818; AZD4818. (S)-2-(2-chloro-5-(3-(5-chloro-3H-spiro[benzofuran-2,4'-piperidin]-1'-yl)-2-hydroxypropoxy)-4-(methylcarbamoyl)phenoxy)-; 2-[2-Chloro-5-[(2S)-3-(5-chlorospiro[3H-1-benzofuran-2,4'-piperidine]-1'-yl)-2-hydroxypropoxy]-4-(methylcarbamoyl)phenoxy]-2-methylpropanoic acid. Grade: >98 %. CAS No. 1003566-93-5. Molecular formula: C27H32Cl2N2O7. Mole weight: 567.46. | |
| CCR1 antagonist 7 | CCR1 antagonist 7 is a chemokine receptor 1 (CCR1) antagonist with an IC50 of 4 nM. Synonyms: 1H-Pyrazole-4-carboxamide, 1-(4-chlorophenyl)-5-methyl-N-[(1S)-1-[2-[(methylamino)sulfonyl]-4-pyridinyl]butyl]-; 1-(4-Chlorophenyl)-5-methyl-N-{(1S)-1-[2-(methylsulfamoyl)-4-pyridinyl]butyl}-1H-pyrazole-4-carboxamide. Grade: 98%. CAS No. 2446154-74-9. Molecular formula: C21H24ClN5O3S. Mole weight: 461.96. | |
| CCR1 antagonist 9 | CCR1 antagonist 9 is a potent and selective antagonist of CCR1 with an IC50? of? 6.8 nM in calcium flux assay. Synonyms: 1-(4-Fluorophenyl)-1H-pyrazolo[3,4-c]pyridine-4-carboxylic acid (2-methanesulfonyl-pyridin-4-ylmethyl)-amide; CCR1 inhibitor 19e; 1H-Pyrazolo[3,4-c]pyridine-4-carboxamide, 1-(4-fluorophenyl)-N-[[2-(methylsulfonyl)-4-pyridinyl]methyl]-; 1-(4-Fluorophenyl)-N-{[2-(methylsulfonyl)-4-pyridinyl]methyl}-1H-pyrazolo[3,4-c]pyridine-4-carboxamide. Grade: ≥95%. CAS No. 1220026-26-5. Molecular formula: C20H16FN5O3S. Mole weight: 425.44. | |
| CCR2 antagonist 1 | CCR2 antagonist 1 is a high-affinity and long-residence-time CCR2 antagonist, with a Ki of 2.4 nM. Synonyms: [(1S,3R)-3-{[(1R)-5-Bromo-2,3-dihydro-1H-inden-1-yl]amino}-1-isopropylcyclopentyl][7-(trifluoromethyl)-3,4-dihydro-2(1H)-isoquinolinyl]methanone; Methanone, [(1S,3R)-3-[[(1R)-5-bromo-2,3-dihydro-1H-inden-1-yl]amino]-1-(1-methylethyl)cyclopentyl][3,4-dihydro-7-(trifluoromethyl)-2(1H)-isoquinolinyl]-; (1R)-5-bromo-N-[(1R,3S)-3-(propan-2-yl)-3-[7-(trifluoromethyl)-1,2,3,4-tetrahydroisoquinoline-2-carbonyl]cyclopentyl]-2,3-dihydro-1H-inden-1-amine. Grade: ≥98%. CAS No. 1683534-96-4. Molecular formula: C28H32BrF3N2O. Mole weight: 549.47. | |
| CCR2 antagonist 3 | CCR2 antagonist 3 is a chemokine receptor 2 (CCR2) antagonist. Synonyms: AZD2927; AZD-2927; (S)-4-Fluoro-N-(1-(3-hydroxyazetidin-1-yl)-3-methylbutan-2-yl)-N,3-dimethylbenzamide; 4-Fluoro-N-[(2S)-1-(3-hydroxy-1-azetidinyl)-3-methyl-2-butanyl]-N,3-dimethylbenzamide. Grade: ≥98%. CAS No. 1380100-86-6. Molecular formula: C17H25FN2O2. Mole weight: 308.39. | |
| CCR4 antagonist 2 | CCR4 antagonist 2 is a potent and orally bioavailable small molecule CCR4 antagonist, with IC50s of 40 and 70 nM for Ca2+ flux and (chemotaxis) CTX, respectively. It inhibits Treg trafficking into the tumor microenvironment without suppressing the number of Treg in healthy tissue. Synonyms: 1H-Pyrazolo[3,4-b]pyrazine-3-carbonitrile, 1-[(1R)-1-(2,4-dichlorophenyl)ethyl]-6-[(4S,5R)-4-[(2S)-2-(hydroxymethyl)-1-pyrrolidinyl]-5-methyl-1-cyclohexen-1-yl]-; 1-[(1R)-1-(2,4-Dichlorophenyl)ethyl]-6-{(4S,5R)-4-[(2S)-2-(hydroxymethyl)-1-pyrrolidinyl]-5-methyl-1-cyclohexen-1-yl}-1H-pyrazolo[3,4-b]pyrazine-3-carbonitrile. Grade: ≥97%. CAS No. 2206788-99-8. Molecular formula: C26H28Cl2N6O. Mole weight: 511.45. | |
| CCR4 antagonist 3 hydrochloride | CCR4 antagonist 3 hydrochloride, a potent, selective and orally active CCR4 antagonist, has a novel piperidinyl-azetidine motif with IC50s of 22 nM and 50 nM in the calcium flux and CTX assay. It has antitumor activity. Synonyms: 1H-Pyrazolo[3,4-b]pyrazine-3-carbonitrile, 1-[(1R)-1-(2,4-dichlorophenyl)ethyl]-6-[3-[(3R)-1-(2-hydroxyethyl)-3-piperidinyl]-1-azetidinyl]-, hydrochloride (1:x). Grade: ≥98%. CAS No. 2174938-71-5. Molecular formula: C24H27Cl2N7O.xHCl. Mole weight: 500.42 (free base). | |
| CCR5 antagonist 1 | CCR5 antagonist 1 is a CCR5 antagonist extracted from WO 2004054974 A2 that can inhibit HIV replication. Synonyms: AC-31371; HY-100261. Grade: >98%. CAS No. 716354-86-8. Molecular formula: C39H46ClF2N5O3S. Mole weight: 738.3. | |
| CCR6 antagonist 1 | CCR6 antagonist 1 is a CCR6 antagonist that inhibits the CCL20/CCR6 axis. CCR6 antagonist 1 can be used in the research of autoimmune-mediated inflammatory diseases, such as inflammatory bowel diseases (IBDs)[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 588674-64-0. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-151435. | |
| CGP 35348 (GABAB Receptor Antagonist, CGP 35348, CGP35348, CGP-35348) | A selective antagonist of post-synaptic GABAB receptors (IC50 = 34uM) that can permeate the blood brain barrier. Exhibits about 10-fold lower affinity for pre-synaptic receptors. Blocks K+-evoked glycine exocytosis in mouse spinal cord and hippocampal nerve endings. Shown to antagonize the potentiating effect of L-baclofen on noradrenaline-induced stimulation of adenylate cyclase in rat cortex slices. Group: Biochemicals. Grades: Highly Purified. CAS No. 123690-79-9. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| CGP 7930 (GABA B Receptor Antagonist, CGP7930, CGP 7930, CGP-7930) | A blood brain barrier permeable, positive allosteric modulator of the metabotropic GABAB receptor. Shown to modulate GABAB receptor in the high affinity state and thereby increases agonist affinity for the receptor. Also enhances agonist potency and efficacy even on recombinant GABAB receptors. Exhibits anxiolytic effects in rodents. Group: Biochemicals. Grades: Highly Purified. CAS No. 57717-80-3. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| CGRP antagonist 1 | CGRP antagonist 1 is a highly potent antagonist of CGRP receptor (Ki = 35 nM; IC50 = 57 nM). Synonyms: (S)-N-(2''-oxo-1,1'',2'',3-tetrahydrospiro[indene-2,3''-pyrrolo[2,3-b]pyridine]-5-yl)-2-(2-oxo-2'',3'',5'',6''-tetrahydrospiro[indoline-3,4''-pyran]-1-yl)acetamide; Spiro[3H-indole-3,4'-[4H]pyran]-1(2H)-acetamide, 2',3',5',6'-tetrahydro-2-oxo-N-[(2S)-1,1',2',3-tetrahydro-2'-oxospiro[2H-indene-2,3'-[3H]pyrrolo[2,3-b]pyridin]-5-yl]-; N-[(2S)-2'-Oxo-1,1',2',3-tetrahydrospiro[indene-2,3'-pyrrolo[2,3-b]pyridin]-5-yl]-2-(2-oxo-2',3',5',6'-tetrahydrospiro[indole-3,4'-pyran]-1(2H)-yl)acetamide. Grade: ≥95%. CAS No. 1123757-49-2. Molecular formula: C29H26N4O4. Mole weight: 494.54. | |
| CNS-1102 (N-(3-Ethylphenyl)-N-methyl-N'-1-naphthalenylguanidine Hydrochloride, Cerestat, Aptiganel Hydrochloride, NMDA Antagonist V) | A non-competitive, subunit non-selective, potent antagonist fornMDA receptors (IC50 = 0.13, 0.068, 0.087, and 0.14uM for NR2A - D, respectively). Widely used as neuroprotective agent after acute traumatic brain injury and stroke in animal researches. Group: Biochemicals. Grades: Highly Purified. CAS No. 137159-92-3. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
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