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| Product | Description | |
|---|---|---|
| Antalarmin hydrochloride | ?98% (HPLC), solid. Group: Fluorescence/luminescence spectroscopy. |  |
| Antalarmin hydrochloride | Antalarmin hydrochloride. Group: Biochemicals. Grades: Purified. CAS No. 220953-69-5. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. |  Worldwide |
| Antalarmin hydrochloride | Antalarmin (hydrochloride) is an oral active non-peptide corticotropin-releasing hormone receptor 1 (CRHR1) antagonist with a K i of 1 nM. Antalarmin hydrochloride suppresses CRH-induced ACTH secretion and blocks CRH and novelty induced anxiety-like behavior in animal models. Antalarmin hydrochloride produces anti-inflammatory effects in arthritis models, and suppresses stress-induced gastric ulceration related to irritable bowel syndrome [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. CAS No. 220953-69-5. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-103377. |  |
| Antalarmin hydrochloride | Antalarmin hydrochloride is the hydrochloride salt of antalarmin, which is a selective nonpeptide antagonist of the corticotropin-releasing hormone (CRH) receptor 1 with Ki value of 1 nM. It suppresses CRF-induced ACTH secretion and blocks CRF- and novelty-induced anxiety-like behavior in animal models of anxiety. It also can reduce cardiovascular, endocrinological and behavioral responses to stressful stimuli through its antagonism of central CRH signaling. It produces anti-inflammatory effects in arthritis models by reducing dose escalation in cocaine-addicted rats and suppresses stress-induced gastric ulceration related to irritable bowel syndrome. Synonyms: N-Butyl-N-ethyl-2,5,6-trimethyl-7-(2,4,6-trimethylphenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine, Monohydrochloride; N-Butyl-N-ethyl-2,5,6-trimethyl-7-(2,4,6-trimethylphenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine, Hydrochloride. Grades: ≥99% by HPLC. CAS No. 220953-69-5. Molecular formula: C24H35N4Cl. Mole weight: 415.01. |  |
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