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| Product | Description | |
|---|---|---|
| Apalutamide | Apalutamide (ARN-509) is a potent and competitive androgen receptor ( AR ) antagonist, binding AR with an IC 50 of 16 nM [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: ARN-509. CAS No. 956104-40-8. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg. Product ID: HY-16060. |  |
| Apalutamide | Apalutamide is a potent and competitive androgen receptor (AR) antagonist with potential antineoplastic activity. It binds to AR in target tissues thereby preventing androgen-induced receptor activation and facilitating the formation of inactive complexes that cannot be translocated to the nucleus. Synonyms: ARN-509; Apalutamide; ARN 509; JNJ56021927; JNJ-56021927; JNJ 56021927; ARN509; 4-[7-[6-cyano-5-(trifluoromethyl)pyridin-3-yl]-8-oxo-6-sulfanylidene-5,7-diazaspiro[3.4]octan-5-yl]-2-fluoro-N-methylbenzamide. Grades: 98%. CAS No. 956104-40-8. Molecular formula: C21H15F4N5O2S. Mole weight: 477.43. |  |
| Apalutamide Impurity 1 | Apalutamide Impurity 1. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: 4-(7-(6-cyano-5-(trifluoromethyl)pyridin-3-yl)-6,8-dioxo-5,7-diazaspiro[3.4]octan-5-yl)-2-fluoro-N-methylbenzamide. CAS No. 1332391-92-0. Molecular formula: C21H15F4N5O3. Mole weight: 461.37. Catalog: APB1332391920. |  |
| Apalutamide Impurity 16 | Apalutamide Impurity 16. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: 4-(7-(6-cyano-5-(trifluoromethyl)pyridin-3-yl)-8-oxo-6-thioxo-5,7-diazaspiro[3.4]octan-5-yl)-N-methylbenzamide. CAS No. 1332389-57-7. Molecular formula: C21H16F3N5O2S. Mole weight: 459.10. Catalog: APB1332389577. | |
| N-Desmethyl Apalutamide | N-Desmethyl Apalutamide. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: 4-(7-(6-cyano-5-(trifluoromethyl)pyridin-3-yl)-8-oxo-6-thioxo-5,7-diazaspiro[3.4]octan-5-yl)-2-fluorobenzamide. CAS No. 1332391-11-3. Molecular formula: C20H13F4N5O2S. Mole weight: 463.07. Catalog: APB1332391113. | |
| Ketodarolutamide | Ketodarolutamide., also known as ORM-15341 and BAY-1896953, is a potent and full antagonist for human AR (hAR) with IC50=38 nM. Ketodarolutamide is a nonsteroidal antiandrogen (NSAA) and the major active metabolite of darolutamide (ODM-201, BAY-1841788), an NSAA which is used in the treatment of prostate cancer in men. Similarly to its parent compound, darolutamide acts as a highly selective, high-affinity, competitive silent antagonist of the androgen receptor (AR). Both agents show much higher affinity and more potent inhibition of the AR relative to the other NSAAs enzalutamide and apalutamide, although they also possess much shorter and comparatively less favorable elimination half-lives. Uses: Designed for use in research and industrial production. Additional or Alternative Names: BAY-1896953; BAY 1896953; BAY1896953; ORM-15341; ORM 15341; ORM15341; Ketodarolutamide. Product Category: Antagonists. Appearance: Solid powder. CAS No. 1297537-33-7. Molecular formula: C19H17ClN6O2. Mole weight: 396.84. Purity: >98%. IUPACName: (S)-5-acetyl-N-(1-(3-(3-chloro-4-cyanophenyl)-1H-pyrazol-1-yl)propan-2-yl)-1H-pyrazole-3-carboxamide. Canonical SMILES: ClC1=C(C#N)C=CC(C2=NN(C[C@H](C)NC(C3=NNC(C(C)=O)=C3)=O)C=C2)=C1. Product ID: ACM1297537337. Alfa Chemistry ISO 9001:2015 Certified. |  |
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