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| Product | Description | |
|---|---|---|
| APS-2-79 | APS-2-79 is a small molecule antagonist of MEK phosphorylation by RAF through direct binding of the KSR active site, and antagonizes oncogenic Ras signalling (IC50 value 120 nM against ATP-biotin probe-labelling of KSR2). Synonyms: 6,7-Dimethoxy-N-(2-methyl-4-phenoxyphenyl)quinazolin-4-amine; APS-2-79; APS 2-79; APS2-79; APS-279; APS 279; APS279. CAS No. 2002381-25-9. Molecular formula: C23H21N3O3. Mole weight: 387.43. |  |
| APS-2-79 HCl | APS-2-79 is a MAPK antagonist which can modulate KSR-dependent MAPK signalling by antagonizing RAF heterodimerization and the conformational changes required for phosphorylation and activation of KSR-bound MEK. APS-2-79 was found to bind to the KSR active site with an IC50 value of 120 nM, antagonizing MEK (MAPKK) phosphorylation by RAF. Synonyms: APS-2-79 HCl; APS2-79 HCl; APS 2-79 HCl; APS-279 HCl; APS279 HCl; APS 279 HCl; SCHEMBL18153640; AKOS032944984; CS-6151; 6,7-dimethoxy-N-(2-methyl-4-phenoxyphenyl)quinazolin-4-amine;hydrochloride. Grades: 99.26 %. CAS No. 2002381-31-7. Molecular formula: C23H21N3O3.HCl. Mole weight: 423.89. | |
| APS-2-79 hydrochloride | ?98% (HPLC). Group: Fluorescence/luminescence spectroscopy. |  |
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