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| Product | Description | |
|---|---|---|
| AR-42 | AR-42. Group: Biochemicals. Alternative Names: (α S) -N-[4-[ (Hydroxyamino) carbonyl]phenyl]-α - (1-methylethyl) benzeneacetamide; (S)-(+)-N-Hydroxy-4-(3-methyl-2-phenyl-butyrylamino)-benzamide; (S)-HDAC 42; OSU-HDAC 42. Grades: Highly Purified. CAS No. 935881-37-1. Pack Sizes: 10mg. Molecular Formula: C18H20N2O3, Molecular Weight: 312.36. US Biological Life Sciences. |  Worldwide |
| AR-42 | AR-42 (HDAC-42; OSU-HDAC42) is a potent, orally bioavailable pan- HDAC inhibitor ( IC 50 =16 nM). AR-42 induces growth inhibition, cell-cycle arrest, apoptosis , and activation of caspases-3/7. AR-42 promotes hyperacetylation of H3, H4, and alpha-tubulin, and up-regulation of p21. AR-42 shows cytotoxicity against various human cancer cell lines [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: HDAC-42; OSU-HDAC42. CAS No. 935881-37-1. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-13265. |  |
| AR-42 | AR-42 is an orally available, broad-spectrum deactylation inhibitor of both histone and non-histone proteins which play an important role in the regulation of gene expression, cell growth and survival. In preclinical studies, AR-42 has demonstrated greater potency and activity in solid and liquid tumors when compared to vorinostat and other deacetylase inhibitors. AR-42 is currently being studied in an investigator-initiated Phase I/IIa clinical study in adult patients with relapsed or refractory multiple myeloma, chronic lymphocytic leukemia or lymphoma. Synonyms: HDAC-42; HDAC42; HDAC 42; OSU-HDAC-42; OSU HDAC 42; AR-42; AR42; AR 42. Grades: 98%. CAS No. 935881-37-1. Molecular formula: C18H20N2O3. Mole weight: 312.37. |  |
| AR 420626 | AR 420626 ,a FFA3 agonist, has been found to be expressed in adipose tissue, the gastrointestinal tract, and the peripheral nervous system, and it is involved in SCFA-dependent energy regulation. Synonyms: AR-420626; AR 420626; AR420626. N-(2,5-Dichlorophenyl)-4-(furan-2-yl)-2-methyl-5-oxo-1,4,5,6,7,8-hexahydroquinoline-3-carboxamide. Grades: ≥98% by HPLC. CAS No. 1798310-55-0. Molecular formula: C21H18Cl2N2O3. Mole weight: 417.29. | |
| AZD-8330 | AZD8330 is an orally active, selective MEK inhibitor with potential antineoplastic activity. AZD8330 specifically inhibits mitogen-activated protein kinase kinase 1 (MEK or MAP/ERK kinase1), resulting in inhibition of growth factor-mediated cell signaling and tumor cell proliferation. Synonyms: AZD8330; AZD-8330; AZD 8330; ARRY424704; ARRY 424704; ARRY-424704; ARRY704; ARRY-704; ARRY 704. Grades: 0.98. CAS No. 869357-68-6. Molecular formula: C16H17FIN3O4. Mole weight: 461.232. | |
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