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| Product | Description | |
|---|---|---|
| AR7 | ?98% (HPLC). Group: Fluorescence/luminescence spectroscopy. |  |
| AR7 | AR7 is an atypical RARA/RARα (retinoic acid receptor, alpha) antagonist. AR7 specifically activates chaperone-mediated-autophagy (CMA) activity without affecting macroautophagy [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 80306-38-3. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-101106. |  |
| AR709 | AR709 is a novel diaminopyrimidine antibiotic. It is currently in development for treatment of community-acquired upper and lower respiratory tract infections. It showed excellent activity against both drug-susceptible and multidrug-resistant pneumococci. Uses: Ar709 is currently in development for treatment of community-acquired upper and lower respiratory tract infections. Synonyms: AR-709; AR 709; 1H-Indole-2-carboxamide, 5-chloro-3-((4-((2,4-diamino-5-pyrimidinyl)methyl)-6,7-dimethoxy-2-benzofuranyl)methyl)-N,N-dimethyl-. Grades: 98%. CAS No. 663214-64-0. Molecular formula: C27H27ClN6O4. Mole weight: 535.00. |  |
| AR-7 | AR-7, also known as Atypical retinoid 7, was developed as a highly potent and selective enhancer of the chaperone-mediated autophagy (CMA) through antagonizing RAR&alpha. AR-7 was suggested to be used at 5-20 μM final concentration in vitro and in cellular assays. Synonyms: 7-Chloro-3-(p-tolyl)-2H-benzo[b][1,4]oxazine; AR 7; AR7; Atypical retinoid 7. CAS No. 80306-38-3. Molecular formula: C15H12ClNO. Mole weight: 257.71. | |
| CA77.1 | CA77.1 is a potent, brain-penetrant and orally active chaperone-mediated autophagy (CMA) activator with favorable pharmacokinetics. CA77.1 is a derivative of AR7 (HY-101106) and can increase the expression of the lysosomal receptor LAMP2A in?lysosomes. CA77.1 improves behavior and neuropathology in PS19 mice model and can be used for alzheimer's?disease research[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2412270-22-3. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-134923. | |
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