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| Product | Description | |
|---|---|---|
| Arachidonyl serotonin | Arachidonyl serotonin. Group: Biochemicals. Grades: Purified. CAS No. 187947-37-1. Pack Sizes: 10mg. US Biological Life Sciences. |  Worldwide |
| Arachidonyl serotonin | Arachidonyl serotonin is a dual target agent of transient receptor potential vanilloid-type I (TRPV1) antagonist and fatty acid amide hydrolase (FAAH) inhibitor, which is responsible for inactivation of anandamide and other endogenous cannabinoids. Its IC50 values are 37-40 nM and 5.6 μM for TRPV1 and FAAH respectively. It inhibits the FAAH activity isolated from mouse neuroblastoma cells with an IC50 value of 12 μM. It is a very tight binding, competitive inhibitor of FAAH. It does not inhibit cPLA2 and is essentially devoid of cannabimimetic activity. It was shown to be present in the ileum and jejunum of the gastrointestinal tract and modulate glucagon-like peptide-1 (GLP-1) secretion. It displays strong analgesic activity against both acute and chronic peripheral pain in rodents. Synonyms: AA-5HT; AA5HT; AA 5HT; N-arachidonoyl-serotonin; Arachidonoyl serotonin; N-[2-(5-hydroxy-1H-indol-3-yl)ethyl]-5Z,8Z,11Z,14Z-eicosatetraenamide; AA-5HT; AA5HT; N-arachidonoyl-serotonin; N-[2-(5-Hydroxy-1H-indol-3-yl)ethyl]-5,8,11,14-eicosatetraenamide; (5Z,8Z,11Z,14Z)-N-(2-(5-hydroxy-1H-indol-3-yl)ethyl)icosa-5,8,11,14-tetraenamide. CAS No. 187947-37-1. Molecular formula: C30H42N2O2. Mole weight: 462.67. |  |
| N-Arachidonoylserotonin | N-Arachidonoylserotonin (Arachidonyl serotonin; AA-5-HT) is a potent fatty acid amide hydrolase (FAAH) inhibitor with an IC 50 value of 1~12 μM. N-Arachidonoylserotonin acts also as an antagonist of transient receptor potential vanilloid-type 1 (TRPV1) channels (IC 50 =70~100 nM). N-Arachidonoylserotonin is analgesic in rodents [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: Arachidonyl serotonin; AA-5-HT. CAS No. 187947-37-1. Pack Sizes: 5 mg (108.07 mM * 0.1 mL in methyl acetate); 10 mg (108.07 mM * 0.2 mL in methyl acetate); 25 mg (108.07 mM * 0.5 mL in methyl acetate); 50 mg (108.07 mM * 1 mL in methyl acetate). Product ID: HY-103337. |  |
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