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| Product | Description | |
|---|---|---|
| ARQ 531 | ARQ 531 Inhibitor. Uses: Scientific use. Product Category: T14323. CAS No. 2095393-15-8. |  |
| ARQ 531 | ARQ-531 is a potent and orally active BTK inhibitor with potential antineoplastic activity. ARQ 531 is a reversible non-covalent inhibitor of Bruton's Tyrosine Kinase (BTK), with IC50s of 0.85 nM and 0.39 nM for WT-BTK and C481S-BTK, respectively. It also has a distinct kinase selectivity profile with strong inhibitory activity against several key oncogenic drivers from TEC, Trk and Src family kinases. In GCB-DLBCL cell lines (SUDHL-4 and DOHH-2), ARQ 531 potently suppressed expression of anti-apoptotic c-Myc and BCL6 oncoproteins in a dose-dependent fashion, and concomitantly induced apoptotic cleavage of PARP protein. Synonyms: ARQ-531. Grades: ≥98%. CAS No. 2095393-15-8. Molecular formula: C25H23ClN4O4. Mole weight: 478.93. |  |
| Nemtabrutinib | ARQ 531 (MK-1026) is a reversible non-covalent and orally active inhibitor of Brutons Tyrosine Kinase ( BTK ), with IC 50 s of 0.85 nM and 0.39 nM for WT-BTK and C481S-BTK, respectively. Uses: Scientific research. Group: Signaling pathways. Alternative Names: ARQ-531; MK-1026. CAS No. 2095393-15-8. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-112215. |  |
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