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| Product | Description | |
|---|---|---|
| ARQ 736 | ARQ 736 is a potent and selective BRAF inhibitor. ARQ 736 is selectively potent in killing cancer cell lines harboring at least one mutated BRAF allele. BRAF mutations were detected in over 60% of melanomas and may account for a significant proportion of colon cancer patients whose tumors are resistant to anti-EGFR therapy. Synonyms: ARQ 736; ARQ736; ARQ-736. CAS No. 1228237-47-5. Molecular formula: C25H25N8Na2O8PS. Mole weight: 630.569. |  |
| ARQ 736 disodium salt | This active molecular is a Proto oncogene protein b raf and Vascular endothelial growth factor A inhibitor originated by ArQule. ARQ 736 is effective in killing cancer cell lines that harboring at least one mutated b raf allele. The b raf protein is really a very important signaling molecule in the MAPK (mitogen activated protein kinase) signaling pathway and it relates to pathogenesis of variety kinds of cancer. In Mar 2014, Phase-I for Solid tumours (late-stage disease) was discontinued in USA. Uses: Solid tumours. Synonyms: ARQ 736 disodium salt; ARQ736 disodium salt; ARQ-736 disodium salt; sodium (R)-(3-(5-(2-((1-((1-methyl-1H-pyrazol-3-yl)sulfonyl)piperidin-3-yl)amino)pyrimidin-4-yl)imidazo[2,1-b]oxazol-6-yl)phenoxy)methyl phosphate;1228237-47-5 free acid. Grades: 98%. CAS No. 1228237-57-7. Molecular formula: C25H25N8Na2O8PS. Mole weight: 674.54. | |
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