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| Product | Description | |
|---|---|---|
| Atezolizumab | Atezolizumab Inhibitor. Uses: Scientific use. Product Category: T9902. CAS No. 1380723-44-3. |  |
| Atezolizumab | Atezolizumab (MPDL3280A) is a selective humanized monoclonal IgG1 antibody against programmed death ligand 1 ( PD-L1 ), used for cancer research. Uses: Scientific research. Group: Inhibitory antibodies. Alternative Names: MPDL3280A. CAS No. 1380723-44-3. Pack Sizes: 1 mg; 5 mg. Product ID: HY-P9904. |  |
| Atezolizumab | Cas No. 1380723-44-3. |  |
| MPDL3280A | A human, Fc optimized, monoclonal antibody directed against the protein ligand PD-L1 (programmed cell death-1 ligand 1), with potential immune checkpoint inhibitory and antineoplastic activities. Atezolizumab binds to PD-L1, blocking its binding to and activation of its receptor programmed death 1 (PD-1) expressed on activated T-cells, which may enhance the T-cell-mediated immune response to neoplasms and reverse T-cell inactivation. In addition, by binding to PD-L1, atezolizumab also prevents binding of this ligand to B7.1 expressed on activated T cells, which further enhances the T-cell-mediated immune response. PD-L1 is overexpressed on many human cancer cell types and on various tumor-infiltrating immune cells. PD-L1 binding to PD-1 on T-cells suppresses the immune system and results in increased immune evasion. PD-1, a transmembrane protein, is a negative regulator of the immune system that limits the expansion and survival of CD8+ T cells. The Fc region of atezolizumab is modified in such a way that it does not induce either antibody-dependent cytotoxicity (ADCC) or complement-dependent cytotoxicity (CDC). Synonyms: Atezolizumab; RG 7446; RO 5541267; RG7446; RO5541267; RG-7446; RO-5541267; TECENTRIQ. CAS No. 1380723-44-3. Molecular formula: C37H62N4O2S. Mole weight: 627. | |
| Tiragolumab | Tiragolumab is an immune checkpoint inhibitor binding to T-cell immunoglobulin and ITIM domain ( TIGIT ). Tiragolumab, alone or in combination with the PD-L1 inhibitor Atezolizumab (HY-P9904), may be effective against multiple solid malignancies-most notably non-small cell lung cancer (NSCLC) [1] [2]. Uses: Scientific research. Group: Inhibitory antibodies. Alternative Names: MTIG-7192A; RG-6058. CAS No. 1918185-84-8. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P9986. | |
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