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| Product | Description | |
|---|---|---|
| Atiprimod | atiprimod is orally bioavailable small molecule belonging to the azaspirane class of cationic amphiphilic agents with anti-inflammatory, antineoplastic, and antiangiogenic properties. Atiprimod inhibits the phosphorylation of signal transducer and activator of transcription 3 (STAT3), blocking the signalling pathways of interleukin-6 and vascular endothelial growth factor (VEGF) and downregulating the anti-apoptotic proteins Bcl-2, Bcl-XL, and Mcl-1, thereby inhibiting cell proliferation, inducing cell cycle arrest, and inducing apoptosis. Synonyms: azaspirane; SKF 106615; SKF106615; SKF-106615; SK&F 106615; SK&F-106615. CAS No. 123018-47-3. Molecular formula: C22H44N2. Mole weight: 336.60. |  |
| Atiprimod dihydrochloride | Atiprimod dihydrochloride is the dihydrochloride salt form of atiprimod, which is an orally bioavailable small molecule belonging to the azaspirane class of cationic amphiphilic agents. It is a JAK2 inhibitor with IC50 value of 397 nM. It has anti-inflammatory, antineoplastic, and anti-angiogenic activities. It inhibits the phosphorylation of signal transducer and activation of transcription 3 (STAT3) and STAT5. It downregulates the anti-apoptotic proteins Bcl-2, Bcl-XL, and Mcl-1 and blocks the signaling pathways of interleukin-6, vascular endothelial growth factor (VEGF). It also inhibits cell growth, induction of cell cycle arrest, and apoptosis in cells expressing the JAK2V617F mutation. Synonyms: N,N-Diethyl-8,8-dipropyl-2-azaspiro[4.5]decane-2-propanamine dihydrochloride. CAS No. 130065-61-1. Molecular formula: C22H46N2Cl2. Mole weight: 409.52. | |
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