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| Product | Description | |
|---|---|---|
| Atpenin a5 | Atpenin a5. Uses: Designed for use in research and industrial production. Additional or Alternative Names: atpenin A5;(2S,4S,5R)-1-(2,4-Dihydroxy-5,6-dimethoxy-3-pyridinyl)-2,4-dimethyl-5,6-dichloro-1-hexanone;(2S,4S,5R)-5,6-Dichloro-1-(2,4-dihydroxy-5,6-dimethoxypyridin-3-yl)-2,4-dimethyl-1-hexanone. Product Category: Heterocyclic Organic Compound. Appearance: White powder. CAS No. 119509-24-9. Molecular formula: C15H21Cl2NO5. Purity: ≥95%. Product ID: ACM119509249. Alfa Chemistry ISO 9001:2015 Certified. |  |
| Atpenin A5 | Antibiotic. Antifungal. Potent and specific mitochondrial complex II (succinate-ubiquinone oxidoreductase) inhibitor. Mitochondrial ATP-sensitive potassium (mK(ATP)) channel activator. Cardioprotective. Modulates mitochondrial ROS generation during cardioprotection.The IC50 value against bovine heart complex II is 3.6nM (which is ~300-fold lower than the IC50 value of carboxin (1.1uM)). It also inhibits fumarate reductase of Ascaris suum (IC50 = 12nM). Inhibition of E. coli succinate dehydrogenase is less potent (IC50 = 5uM). By co-crystallization studies of atpenin A5 and complex II, the binding site of atpenin A5 was found to be the quinone-binding site of complex II. Additionally, atpenin A5 has been shown to have a protective action against ischemia-reperfusion via the activation of mitochondrial KATP channels. Group: Biochemicals. Alternative Names: 3-[(2S,4S,5R)-5,6-Dichloro-2,4-dimethyl-1-oxohexyl]-4-hydroxy-5,6-dimethoxy-2(1H)-pyridinone. Grades: Highly Purified. CAS No. 119509-24-9. Pack Sizes: 250ug, 1mg. Molecular Formula: C15H21Cl2NO5. US Biological Life Sciences. |  Worldwide |
| Atpenin A5 | Atpenin A5 is an inhibitor of SDHB, SDHC and SDHD. It is an antifungal antibiotic produced by Penicillium sp. and an ubiquinone-binding site inhibitor of succinate dehydrogenase with IC50s of 12 nM for nematode and IC50s of 3.7 nM for mammalian mitochondria. Atpenin A5 is the most effective inhibitor against complex II from all the atpenins and has been shown to protect against cardiac-reperfusion injury in rat studies through the stimulation of mitochondrial KATP channels. Synonyms: Antibiotic FO-125A5. Grades: ≥95%. CAS No. 119509-24-9. Molecular formula: C15H21Cl2NO5. Mole weight: 366.2. |  |
| Atpenin A5 (3-[(2S,4S,5R)-5,6-Dichloro-2,4-dimethyl-1-oxohexyl]-4-hydroxy-5,6-dimethoxy-2(1H)-pyridinone) | Synthetic. Originally isolated from Penicillium sp. strain. An antibiotic and antifungal agent. Potent and specific mitochondrial complex II (succinate-ubiquinone oxidoreductase) inhibitor and mitochondrial ATP-sensitive potassium (mK(ATP)) channel activator. Modulates mitochondrial ROS generation during cardioprotection. Group: Biochemicals. Grades: Highly Purified. CAS No. 119509-24-9. Pack Sizes: 250ug, 1mg. US Biological Life Sciences. | Worldwide |
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