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| Product | Description | |
|---|---|---|
| Avagacestat | ?98% (HPLC). Group: Fluorescence/luminescence spectroscopy. |  |
| Avagacestat | Avagacestat (BMS-708163) is a potent inhibitor of γ-secretase , with IC 50 s of 0.27 nM and 0.30 nM for Aβ42 and Aβ40 inhibition; Avagacestat (BMS-708163) also inhibits NICD (Notch IntraCellular Domain) with IC 50 of 0.84 nM and shows weak inhibition of CYP2C19, with IC 50 of 20 μM. Avagacestat can be used for Alzheimer disease research. Uses: Scientific research. Group: Signaling pathways. Alternative Names: BMS-708163. CAS No. 1146699-66-2. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-50845. |  |
| Avagacestat | BMS-708163 is a potent and orally bioavailable inhibitor of γ-secretase that more potently inhibits the cleavage of APP (IC50 = 0.30 nM) to Aβ40 than signaling through Notch (IC50s = 58 nM). Uses: Gamma secretase inhibitors and modulators. Synonyms: Avagacestat; BMS 708163; (2R)-2-[(4-chlorophenyl)sulfonyl-[[2-fluoro-4-(1,2,4-oxadiazol-3-yl)phenyl]methyl]amino]-5,5,5-trifluoropentanamide. Grades: >98%. CAS No. 1146699-66-2. Molecular formula: C20H17ClF4N4O4S. Mole weight: 520.89. |  |
| (R) -2-[[4-chlorophenyl) sulfonyl][[2-fluoro-4- (1, 2, 4-oxadiazol-3-yl) phenyl]methyl]amino]-5, 5, 5-trifluoropentanamide | (R) -2-[[4-chlorophenyl) sulfonyl][[2-fluoro-4- (1, 2, 4-oxadiazol-3-yl) phenyl]methyl]amino]-5, 5, 5-trifluoropentanamide. Group: Biochemicals. Alternative Names: (2R) -2-[N-[ (4-Chlorophenyl) sulfonyl]-N-[[2-fluoro-4- (1, 2, 4-oxadiazol-3-yl) phenyl]methyl]amino]-5, 5, 5-trifluoropentanamide; Avagacestat; BMS 708163; BMS 708163-01. Grades: Highly Purified. Pack Sizes: 5mg. Molecular Formula: C20H17ClF4N4O4S, Molecular Weight: 520.88. US Biological Life Sciences. |  Worldwide |
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