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| Product | Description | |
|---|---|---|
| Avapritinib | Avapritinib (BLU-285) is a highly potent, selective, and orally active KIT and PDGFRA activation loop mutant kinases inhibitor with IC 50 s of 0.27 and 0.24 nM for KIT D816V and PDGFRA D842V , respectively. Avapritinib (BLU-285) binds the active conformation of the kinase and shows antitumor activity. Avapritinib (BLU-285) attenuates the transport function of both ABCB1 and ABCG2 [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: BLU-285. CAS No. 1703793-34-3. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-101561. |  |
| Avapritinib | BLU-285 is a potent and selective inhibitor of exon 17 mutant KIT (IC50 = 0.27 nM for KIT D816V). BLU-285 showed dose-dependent, robust anti-tumor efficacy in a TKI-resistant KIT exon 11/17 mutant GIST PDX model through inhibition of tumor growth, proliferation, KIT signaling and induction of apoptosis. Synonyms: (1S)-1-(4-fluorophenyl)-1-[2-[4-[6-(1-methylpyrazol-4-yl)pyrrolo[2,1-f][1,2,4]triazin-4-yl]piperazin-1-yl]pyrimidin-5-yl]ethanamine; BLU-285; BLU 285; BLU285; UNII-513P80B4YJ; SCHEMBL16652297. CAS No. 1703793-34-3. Molecular formula: C26H27FN10. Mole weight: 498.56. |  |
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