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| Product | Description | |
|---|---|---|
| AY 9944 | Cholesterol synthesis inhibitor; inhibits both 7-dehydrocholesterol ?7-reductase and ?8,7-sterol isomerase. A sonic hedgehog inhibitor. Group: Biochemicals. Alternative Names: trans-N1, N4-Bis [ (2-chlorophenyl) methyl ] -1, 4-cyclohexane dimethanamine Hydrochloride; N, N'-Bis (o-chlorobenzyl)-trans-1, 4-cyclohexanebis (methylamine) Dihydrochloride. Grades: Highly Purified. CAS No. 366-93-8. Pack Sizes: 10mg. US Biological Life Sciences. |  Worldwide |
| AY 9944 dihydrochloride | AY 9944 dihydrochloride. Group: Biochemicals. Grades: Purified. CAS No. 366-93-8. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| AY 9944 dihydrochloride | AY 9944 dihydrochloride is the dihydrochloride salt of AY 9944, which is an amphiphilic and cell-permeable diamine and acts as a sonic hedgehog inhibitor. It may induce a rapid and irreversible reduction in acidic-sphingomyelinase activity in fibroblasts. It is also a potent inhibitor of cholesterol biosynthesis and esterification, and shows teratogenic properties. It inhibits Δ7-dehydrocholesterol reductase and cholesterol esterificatio, thus reduces cholesterol biosynthesis. It blocks the cellular response to Hh proteins. It is important in Sonic Hedgehog signaling and teratogenicity studies. Synonyms: AY-9944; AY 9944; AY9944; trans-N1,N4-Bis[(2-chlorophenyl)methyl]-1,4-cyclohexanedimethanamine Hydrochloride; N,N'-Bis(o-chlorobenzyl)-trans-1,4-cyclohexanebis(methylamine) Dihydrochloride; trans-N,N-bis[2-Chlorophenylmethyl]-1,4-cyclohexanedimethanamine dihydrochloride. Grades: ≥99% by HPLC. CAS No. 366-93-8. Molecular formula: C22H30Cl4N2. Mole weight: 464.30. |  |
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