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| Product | Description | |
|---|---|---|
| AZ31 | AZ31 is a a potent, highly selective, and orally active ATM inhibitor with an IC 50 of <1.2 nM for ATM enzyme, and an IC 50 of 46 nM for ATM in cell. AZ31 shows excellent selectivity over ATR (>500-fold) and excellent PIKK-family selectivity and pan-kinase selectivity. AZ31 is a potent radiosensitizer in vitro, it can be used for the research of cancer [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2088113-98-6. Pack Sizes: 5 mg; 10 mg. Product ID: HY-112198. |  |
| AZ31 | AZ31 is a potent and highly selective ATM inhibitor with an IC50 of <1.2 nM. It displays excellent selectivity against a panel of kinases including ATR, DNAPK, mTOR, PI3Kα, PI3Kβ, PI3Kγ, GSK3β and KDR. AZ 31 also shows significant tumor growth reduction in the SW620 xenograft model combined with irinotecan. Synonyms: AZ 31; AZ-31;(S)-6-(6-(methoxymethyl)pyridin-3-yl)-4-((1-(tetrahydro-2H-pyran-4-yl)ethyl)amino)quinoline-3-carboxamide. Grades: ≥98%. CAS No. 2088113-98-6. Molecular formula: C24H28N4O3. Mole weight: 420.50. |  |
| AZ3146 | ?98% (HPLC). Group: Fluorescence/luminescence spectroscopy. |  |
| Magnesium Aluminum Zinc plate, alloy AZ31B, 6.35mm (0.25in) thick | Magnesium Aluminum Zinc plate, alloy AZ31B, 6.35mm (0.25in) thick. Group: Alloys. |  |
| Magnesium Aluminum Zinc plate, alloy AZ31B, 9.52mm (0.375in) thick | Magnesium Aluminum Zinc plate, alloy AZ31B, 9.52mm (0.375in) thick. Group: Alloys. | |
| AZ 3146 | AZ3146 is a selective Mps1 inhibitor with IC50 of ~35 nM, contributes to recruitment of CENP-E (kinesin-related motor protein), less potent to FAK, JNK1, JNK2, and Kit. Synonyms: AZ3146; AZ 3146; AZ-3146. Grades: >98%. CAS No. 1124329-14-1. Molecular formula: C24H32N6O3. Mole weight: 452.55. | |
| AZ32 | AZ32 is an orally bioavailable and blood-brain-barrier penetrating ATM inhibitor (AZ32) that radiosensitizes intracranial gliomas in mice. AZ32 was highly efficient in vivo as radiosensitizer in syngeneic and human, orthotopic mouse glioma model compared with AZ31. AZ32 is the first ATMi with oral bioavailability shown to radiosensitize glioma and improve survival in orthotopic mouse models. Uses: Designed for use in research and industrial production. Additional or Alternative Names: AZ32; AZ-32; AZ 32. Product Category: Inhibitors. Appearance: Solid powder. CAS No. 2288709-96-4. Molecular formula: C20H16N4O. Mole weight: 328.38. Purity: >98%. IUPACName: N-methyl-4-(6-phenylimidazo[1,2-a]pyrazin-3-yl)benzamide. Canonical SMILES: O=C(NC)C(C=C1)=CC=C1C2=CN=C3C=NC(C4=CC=CC=C4)=CN32. Product ID: ACM2288709964. Alfa Chemistry ISO 9001:2015 Certified. Categories: AZD-2327. |  |
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