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| Product | Description | |
|---|---|---|
| AZD-9291 | AZD-9291 is a third-generation EGFR inhibitor, showed promise in preclinical studies and provides hope for patients with advanced lung cancers that have become resistant to existing EGFR inhibitors. AZD9291 is highly active in preclinical models and is well tolerated in animal models. AZD 9291 is an irreversible inhibitor of epidermal growth factor receptor (EGFR) sensitizing and T790M resistance mutations (IC50s = 15-17 nM) while sparing the wild-type form of the receptor (IC50 = 480 nM). It binds the related IGF1R and hERG receptors with significantly reduced potency (IC50s = 2.9 and 16.2 μM, respectively). Uses: For research used only. Synonyms: Mereletinib; EGFR inhibitor; AZD9291; AZD 9291. Grades: 98%. CAS No. 1421373-65-0. Molecular formula: C28H33N7O2. Mole weight: 499.61. |  |
| AZD-9291 mesylate | AZD-9291 is a third-generation EGFR inhibitor, showed promise in preclinical studies and provides hope for patients with advanced lung cancers that have become resistant to existing EGFR inhibitors. AZD9291 is highly active in preclinical models and is well tolerated in animal models. It inhibits both activating and resistant EGFR mutations while sparing the normal form of EGFR that is present in normal skin and gut cells, thereby reducing the side effects encountered with currently available medicines. Synonyms: Mereletinib mesylate; EGFR inhibitor; AZD9291 mesylate; AZD 9291 mesylate. Grades: >98%. CAS No. 1421373-66-1. Molecular formula: C29H37N7O5S. Mole weight: 595.71. | |
| Osimertinib | Osimertinib (AZD9291) is a covalent, orally active, irreversible, and mutant-selective EGFR inhibitor with an apparent IC 50 of 12 nM against L858R and 1 nM against L858R/T790M, respectively. Osimertinib overcomes T790M-mediated resistance to EGFR inhibitors in lung cancer [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: AZD-9291; Mereletinib. CAS No. 1421373-65-0. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg; 200 mg; 500 mg; 1 g. Product ID: HY-15772. |  |
| Osimertinib mesylate | Osimertinib mesylate (AZD9291 mesylate) is a covalent, orally active, irreversible, and mutant-selective EGFR inhibitor with an apparent IC 50 of 12 nM against L858R and 1 nM against L858R/T790M. Osimertinib overcomes T790M-mediated resistance to EGFR inhibitors in lung cancer [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: AZD-9291 mesylate; Mereletinib mesylate. CAS No. 1421373-66-1. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg; 200 mg; 500 mg; 1 g. Product ID: HY-15772A. | |
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