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| Product | Description | |
|---|---|---|
| AZD3839 | AZD3839, also called CHEMBL2177913, as a potent BACE1 inhibitor it is a clinical candidate for the treatment of Alzheimer's disease. Studies indicate that the inhibition of BACE1 impedes the production of Aβ peptide. Synonyms: AZD3839; AZD-3839; AZD 3839. (3S)-3-[2-(difluoromethyl)pyridin-4-yl]-7-fluoro-3-(3-pyrimidin-5-ylphenyl)isoindol-1-amine; CHEMBL2177913; I8ID590133; UNII-I8ID590133; I8ID590133; SCHEMBL1358337; BDBM50398264; (1S)-1-(2-(Difluoromethyl)pyridin-4-yl)-4-fluoro-1-(3-(pyrimidin-5-yl)phenyl)-1H-isoindol-3-amine; 1227163-84-9; 1H-Isoindol-3-amine, 1-(2-(difluoromethyl)-4-pyridinyl)-4-fluoro-1-(3-(5-pyrimidinyl)phenyl)-, (1S)-. CAS No. 1227163-84-9. Molecular formula: C24H16F3N5. Mole weight: 431.41. |  |
| AZD3839 free base | AZD3839 free base is a potent and selective orally active, brain-permeable BACE1 inhibitor ( K i=26 nM). AZD3839 free base shows 14 and >1000-fold selectivity against BACE2 and cathepsin D, respectively. AZD3839 free base exhibits dose- and time-dependent lowering of plasma, brain, and cerebrospinal fluid Aβ levels in mouse, guinea pig, and non-human primate. AZD3839 free base can be used for the research of Alzheimer's disease [1] [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1227163-84-9. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg. Product ID: HY-13438. |  |
| 1- (3-Bromophenyl)-4-fluoro-1- (2- (trifluoromethyl (pyridine-4-yl-1H-isoindol-3-amine | 1- (3-Bromophenyl)-4-fluoro-1- (2- (trifluoromethyl (pyridine-4-yl-1H-isoindol-3-amine is an intermediate in the synthesis of AZD3839 which is a potent and selective inhibitor of human Beta-secretase 1 (BACE1). Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 10mg, 25mg. Molecular Formula: C20H12BrF4N3. US Biological Life Sciences. |  Worldwide |
| 2-(3-Bromobenzoyl)-6-fluorobenzonitrile | 2-(3-Bromobenzoyl)-6-fluorobenzonitrile is an intermediate in the synthesis of AZD3839 which is a potent and selective inhibitor of human Beta-secretase 1 (BACE1). Group: Biochemicals. Grades: Highly Purified. CAS No. 1227162-77-7. Pack Sizes: 50mg, 100mg. Molecular Formula: C14H7BrFNO. US Biological Life Sciences. | Worldwide |
| 4-Fluoro-1-(3-(pyrimidin-5-yl)phenyl)-1-(2-(trifluoromethyl)pyridin-4-yl)-1H-isoindol-3-amine | AZD3839, with the potential to treat Alzheimer's disease, was reported as a selective BACE1 inhibitor (IC50=4.8μM) for which concentration-dependent lowering of Ab peptides in cellular systems and three pre-clinical species were demonstrated. Phase-I for Alzheimer's disease in United Kingdom (PO) was discontinued in 2012 in UK. Uses: Alzheimer's disease. Synonyms: 4-Fluoro-1-[3-(5-pyrimidinyl)phenyl]-1-[2-(trifluoromethyl)-4-pyridinyl]-1H-isoindol-3-amine; AZD-3839; AZD 3839;(3S)-3-(2-(difluoromethyl)pyridin-4-yl)-7-fluoro-3-(3-(pyrimidin-5-yl)phenyl)isoindolin-1-amine. Grades: 98%. CAS No. 1227163-56-5. Molecular formula: C24H15F4N5. Mole weight: 449.40. | |
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