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| Product | Description | |
|---|---|---|
| AZD8186 | AZD8186 is and inhibitor of the beta isoform of phosphoinositide-3 kinase (PI3K), with potential antineoplastic activity. Upon administration, PI3Kbeta inhibitor AZD8186 selectively inhibits the activity of PI3Kbeta in the PI3K/Akt/mTOR signaling pathway, which may result in a decrease of tumor cell proliferation. It also induces cell death in PI3K-expressing cancer cells. By specifically targeting class I PI3K beta, this agent may be more efficacious and less toxic than pan PI3K inhibitors. PI3K-mediated signaling is often dysregulated in cancer cells and contributes to increased tumor cell growth, survival, and tumor resistance to a variety of antineoplastic agents. AZD8186 is currently under Phase I clinical trials. Uses: Designed for use in research and industrial production. Additional or Alternative Names: AZD8186; AZD 8186; AZD-8186. Product Category: Inhibitors. Appearance: Solid powder. CAS No. 1627494-13-6. Molecular formula: C24H25F2N3O4. Mole weight: 457.4. Purity: >98%. IUPACName: (R)-8-(1-((3,5-difluorophenyl)amino)ethyl)-N,N-dimethyl-2-morpholino-4-oxo-4H-chromene-6-carboxamide. Canonical SMILES: O=C(N(C)C)C1=CC([C@@H](C)NC2=CC(F)=CC(F)=C2)=C3C(C(C=C(O3)N4CCOCC4)=O)=C1. Product ID: ACM1627494136. Alfa Chemistry ISO 9001:2015 Certified. |  |
| AZD8186 | AZD8186 is a PI3K inhibitor, which potently inhibits PI3Kβ (IC 50 =4 nM) and PI3Kδ (IC50 50 =12 nM) with selectivity over PI3Kα (IC 50 =35 nM) and PI3Kγ (IC 50 =675 nM). Uses: Scientific research. Group: Signaling pathways. CAS No. 1627494-13-6. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-12330. |  |
| AZD8186 | AZD 8186 is a selective PI3Kβ/δ inhibitor (IC50= 0.003 μM for PI3Kβ, and 0.017 μM for PI3Kδ) with potential antineoplastic activity. It shows no significant binding against a panel of 442 other kinases when tested at a concentration of 10 μM and exhibits high oral efficacy in mouse cancer models. Synonyms: (R)-8-(1-((3,5-difluorophenyl)amino)ethyl)-N,N-dimethyl-2-morpholino-4-oxo-4H-chromene-6-carboxamide; AZD8186; AZD 8186; AZD-8186. CAS No. 1627494-13-6. Molecular formula: C24H25F2N3O4. Mole weight: 457.4. |  |
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