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| Product | Description | |
|---|---|---|
| Baccatin VI | Baccatin VI. Grades: CAS No. 57672-79-4. Product ID: 1-01464. Molecular formula: C37H46O14. Mole weight: 714.76. Purity: 80-95%. |  |
| Baccatin VI | Baccatin VI. Group: Biochemicals. Alternative Names: (2aR, 4S, 4aS, 5R, 6R, 9S, 11S, 12S, 12aR, 12bS)-2a, 3, 4, 4a, 5, 6, 9, 10, 12, 12a-Decahydro-4a, 8, 13, 13-tetramethyl-4, 5, 6, 9, 12b-pentaacetate 12-benzoate methano-1H-cyclodeca[3,4]benz[1,2-b]oxete-4,5,6,9,11,12,12b-heptol. Grades: Highly Purified. CAS No. 57672-79-4. Pack Sizes: 2mg, 5mg, 10mg, 25mg, 50mg. Molecular Formula: C37H46O14. US Biological Life Sciences. |  Worldwide |
| 19-Hydroxy-10-deacetyl baccatin-III | 19-Hydroxy-10-deacetylbaccatin III is an impurity of Baccatin III and is extracted from the needles of Taxus Baccata. It is used to synthesize 19-hydroxydocetaxel which is a compound that exhibits high level of cytotoxicity in vitro experimental models. Synonyms: (2aR,4S,4aR,6R,9S,11S,12S,12aR,12bS)-12b-(Acetyloxy)-12-(benzoyloxy)-1,2a,3,4,4a,6,9,10,11,12,12a,12b-dodecahydro-4,6,9,11-tetrahydroxy-4a-(hydroxymethyl)-8,13,13-trimethyl-7,11-methano-5H-cyclodeca[3,4]benz[1,2-b]oxet-5-one. Grades: > 95%. CAS No. 154083-99-5. Molecular formula: C29H36O11. Mole weight: 560.6. |  |
| 19-Hydroxy-10-deacetylbaccatin III | 19-Hydroxy-10-deacetylbaccatin III is an impurity of Baccatin III and is extracted from the needles of Taxus Baccata. It is used to synthesize 19-hydroxydocetaxel which is a compound that exhibits high level of cytotoxicity in vitro experimental models. Group: Biochemicals. Grades: Highly Purified. CAS No. 154083-99-5. Pack Sizes: 250ug, 1mg. Molecular Formula: C29H36O11, Molecular Weight: 560.59. US Biological Life Sciences. | Worldwide |
| Ortataxel | Ortataxel, also known as IDN5109, is novel seimsynthetic taxane with potential anticancer activity. Ortataxel is characterized by its high tolerability, antitumor efficacy, ability to overcome multidrug resistance, and oral bioavailabilty. In in vitro experiments, IDN5109 showed antiproliferative effects against HNSCC cell lines. After treatment with IDN5109, Bcl-2 and Bcl-XL were down-regulated, Bax was up-regulated, and caspase-3 was activated. After treatment with IDN5109, concentrations of both VEGF and IL-8 in the culture supernatant of HNSCC cells decreased. In in vivo experiments, the oral administration of IDN5109 showed antitumor effects against HNSCC tumor xenografts. Immunohistochemistry showed that IDN5109 inhibited tumor angiogenesis and induced apoptosis in HNSCC cells, producing a decreased blood vessel density and increased apoptosis index. On the basis of these results, IDN5109 is useful as a chemotherapeutic agent against HNSCC. Uses: Antineoplastic agents. Synonyms: Bay-59-8862, Bay 59 8862; SB-T-101131; SB T 101131; 13-(N-tert-butoxycarbonyl-beta-isobutyisoserinyl)-14-hydroxy-baccatin-1,14-carbonate. CAS No. 186348-23-2. Molecular formula: C44H57NO17. Mole weight: 871.93. | |
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