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| Product | Description | |
|---|---|---|
| Bardoxolone | Bardoxolone. Group: Biochemicals. Grades: Highly Purified. CAS No. 218600-44-3. Pack Sizes: 5mg, 10mg, 25mg, 50mg, 100mg. US Biological Life Sciences. |  Worldwide |
| Bardoxolone | Bardoxolone is a synthetic oleanane triterpenoid that exerts multifunctional activities in the control of cellular growth and differentiation. Bardoxolone is capable of activating the transcription factor peroxisome proliferator activator receptor-γ (PPARγ), its apoptotic effects in malignant cells have been shown to occur independently of PPAR&gamma. Bardoxolone was developed as an potential drug for the improvement of hyperglycemia, proteinuria, glomerulus structure, serum creatine, which may in turn be beneficial to treat diabetic kidney diseases, cancer and thromboembolic events. Synonyms: CDDO; RTA 401; RTA401; RTA-401. Grades: >98%. CAS No. 218600-44-3. Molecular formula: C31H41NO4. Mole weight: 491.66. |  |
| Bardoxolone | Bardoxolone (RTA 401; CDDO) is a novel nuclear regulatory factor ( NRf-2 ) activator. Bardoxolone is a potent necroptosis inhibitor that inhibits Z-VAD-FMK-induced necroptosis. Bardoxolone methyl enhances the antioxidant system, modulates inflammatory cytokines and inhibits apoptosis in rat kidney, demonstrating inhibition on APAP-induced acute kidney injury (AKI) and analgesic effect. Additionally, Bardoxolone methyl decreases Paclitaxel (PAC) (HY-B0015)-induced mitochondrial damage in neuronal cells. Bardoxolone methyl is promising for the research of chemotherapy-induced neuropathic pain and chronic kidney disease [1] [2] [3] [4]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: CDDO; RTA 401. CAS No. 218600-44-3. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-14909. |  |
| Bardoxolone methyl | Bardoxolone methyl (also known as "RTA 402" and "CDDO-methyl ester") is an orally-available first-in-class synthetic triterpenoid belonging to the antioxidant inflammation modulator (AIM) class. It is the most potent known inducer of the Nrf2 pathway to enter clinical development and works to suppress both oxidative stress and inflammation. Uses: A nrf2 activator that inhibits proliferation and induces differentiation and apoptosis in various cancer cells; antioxidant inflammation modulator (aim); for the treatment of advanced chronic kidney disease (ckd) in type 2 diabetes mellitus patients. Synonyms: CDDO Methyl ester; CDDOMe; RTA 402; RTA-402; RTA402; TP-155; TP155; TP 155; 2-cyano-3,12-dioxoolean-1,9-dien-28-oic acid methyl ester; bardoxolone methyl; CDDO-Me; methyl 2-cyano-3,12-dioxoolean-1,9-dien-28-oate; (4aS,6aR,6bS,8aR,12aS,14bS)-Methyl 11-cyano-2, 2, 6a, 6b, 9, 9, 12a-heptamethyl-10, 14-dioxo-1, 2, 3, 4, 4a, 5, 6, 6a, 6b, 7, 8, 8a, 9, 10, 12a, 14, 14a, 14b-octadecahydropicene-4a-carboxylate. Grades: ≥ 98.0%. CAS No. 218600-53-4. Molecular formula: C32H43NO4. Mole weight: 505.70. | |
| Bardoxolone methyl | Bardoxolone methyl. Group: Biochemicals. Alternative Names: CDDO-methyl ester. Grades: Highly Purified. CAS No. 218600-53-4. Pack Sizes: 5mg, 10mg, 25mg, 50mg, 100mg. Molecular Formula: C32H43NO4. US Biological Life Sciences. | Worldwide |
| Bardoxolone methyl | Bardoxolone methyl (NSC 713200; RTA 402; CDDO Methyl ester) is a synthetic triterpenoid compound with potential antineoplastic and anti-inflammatory activities, acting as an activator of the Nrf2 pathway and an inhibitor of the NF-κB pathway. Uses: Designed for use in research and industrial production. Additional or Alternative Names: Bardoxolone methyl;CDDO-Me;CDDO methyl ester;218600-53-4;RTA 402;NSC 713200;NSC713200;RTA-402;RTA402;UNII-CEG1Q6OGU1;CEG1Q6OGU1;NSC-713200;bardoxolone-methyl;(4aS,6aR,6bS,8aR,12aS,14aR,14bS)-methyl 11-cyano-2,2,6a,6b,9,9,12a-heptamethyl-10,14-dioxo-1,2,3,4,4a,5,6,6a,6b,7,8,8a,9,10,12a,14,14a,14b-octadecahydropicene-4a-carboxylate;CDDO-Methyl ester;methyl 2-cyano-3,12-dioxooleana-1,9(11)-dien-28-oa. Product Category: Inhibitors. Appearance: Solid. CAS No. 218600-53-4. Molecular formula: C32H43NO4. Mole weight: 505.7g/mol. Purity: 0.9972. IUPACName: methyl (4aS,6aR,6bS,8aR,12aS,14aR,14bS)-11-cyano-2,2,6a,6b,9,9,12a-heptamethyl-10,14-dioxo-1,3,4,5,6,7,8,8a,14a,14b-decahydropicene-4a-carboxylate. Canonical SMILES: CC1(CCC2(CCC3(C(C2C1)C(=O)C=C4C3(CCC5C4(C=C(C(=O)C5(C)C)C#N)C)C)C)C(=O)OC)C. ECNumber: 606-850-4. Product ID: ACM218600534. Alfa Chemistry ISO 9001:2015 Certified. |  |
| Bardoxolone methyl | Bardoxolone methyl (NSC 713200; RTA 402; CDDO Methyl ester) is a synthetic triterpenoid compound with potential antineoplastic and anti-inflammatory activities, acting as an activator of the Nrf2 pathway and an inhibitor of the NF-κB pathway. Uses: Scientific research. Group: Signaling pathways. Alternative Names: RTA 402; NSC 713200; CDDO Methyl ester. CAS No. 218600-53-4. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg; 200 mg; 500 mg. Product ID: HY-13324. | |
| CDDO-Me (NSC 713200, Bardoxolone Methyl, BARD, Methyl-2-cyano-3,12-dioxooleana-1,9(11)-dien-28-oate) | A cell-permeable, bioavailable synthetic oleanane triterpenoid compound with anti-inflammatory, anti-tumor and cytoprotective properties. Shown to significantly reduce the expression of several inflammatory mediators, including IL-6, IL-10, IL-12, TNFalpha, Mip1alpha and others. Reverses high fat diet-induced type 2 diabetes in C57BL/6 mice (3mg/kg) and improves glucose homeostasis and insulin sensitivity. Down-regulates lipogenic gene expression in hepatocytes. Exhibits anti-proliferative activity in osteosarcoma cells (IC50 = 800, 150, 330, and 170nM in HOB-c, KHOS, KHOSR2, and U2OS cells, respectively). Enhances the effectiveness of chemotherapeutic agents by inducing intrinsic mitochondrial-dependent apoptotic pathway. Reported to interact with multi cellular targets, namely, Nrf2-Keap1, IKK, JAK-STAT, PPARg, ErbB2, PTEN, mTOR and Arp3 and covalently modify active site Cys residue via Michael addition. Group: Biochemicals. Grades: Highly Purified. CAS No. 218600-53-4. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| CDDO Methyl Ester | CDDO Methyl Ester is a synthetic triterpenoid that inhibits IκBα kinase and enhances apoptosis induced by TNF and chemotherapeutic agents through down-regulation of expression of nuclear factor κB-regulated gene products in human leukemic cells. CDDO Methyl Ester is a novel therapeutic agent in the treatment of acute myeloid leukemia and in the treatment of pancreatic cancer as well as other forms of cancer. Group: Biochemicals. Alternative Names: 2-Cyano-3,12-dioxooleana-1,9(11)-dien-28-oic Acid Methyl Ester; Bardoxolone Methyl; CDDO-Me; Methyl 2-cyano-3,12-dioxooleana-1,9(11)-dien-28-oate; NSC 713200; RTA 402. Grades: Highly Purified. CAS No. 218600-53-4. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
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