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| Product | Description | |
|---|---|---|
| Basmisanil | Basmisanil is a highly selective inverse agonist/negative allosteric modulator GABAAα5 receptors. It was developed by Roche to treat cognitive impairment associated with Down syndrome. In Apr 2016, Roche completed the phase II in Down syndrome (In adolescents, In adults) in USA, Argentina, Canada, France, Italy, Mexico, New Zealand, Singapore, Spain and the UK. In Sep 2016, Phase-II clinical trials in Neurological disorders (In adults, In the elderly) in Spain was on going. Uses: Down syndrome; neurological disorders. Synonyms: (1,1-dioxidothiomorpholino)(6-((3-(4-fluorophenyl)-5-methylisoxazol-4-yl)methoxy)pyridin-3-yl)methanone; RG 1662; RG-1662; RG1662; RO5186582; RO-5186582; RO 5186582. Grades: 98%. CAS No. 1159600-41-5. Molecular formula: C21H20FN3O5S. Mole weight: 445.47. |  |
| Basmisanil | Basmisanil (RG1662) is a highly selective orally active α subunit-containing GABAA receptors (GABAAα5) negative allosteric modulator (NAMs). Basmisanil can inhibit GABAA-α5 with a K i value of 5 nM and IC 50 value of 8 nM, respectively. Basmisanil can be used for the research of multiple cognitive and psychiatric disorders [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: RG1662; RO5186582. CAS No. 1159600-41-5. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-16716. |  |
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